Safety Data Sheet

Section 1: Chemical Product and Company Identification

1.1 Product Identification

Chemical Name: Choline chloride EMPROVE® ESSENTIAL DAB 10

Product Number: 5.00117

Item Number: 500117

Brand: Millipore

1.2 Other Names

No data available.

1.3 Use of the Substance/Mixture and Advice on Use

Recommended Use and Restrictions: Pharmaceutical production and analysis.

1.4 Details of the Supplier of the Safety Data Sheet

Manufacturer, Importer, or Distributor: Taiwan Merck Co., Ltd.

Name, Address, and Phone Number: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, TAIWAN

Company: MERCK LTD.

Address: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, Taiwan

Company: Merck KGaA

Address: 64271 Darmstadt, Germany

Phone: +49 6151 72-0

Fax: +886 2-2162-1111

Fax: +886 2-8751-6262

1.5 Emergency Contact Telephone Number

Emergency Phone Number: CHEMTREC: 00801 49 1821
CHEMTREC Taipei: +886 2 7741 4207

Section 2: Hazard Identification

Hazard Classification

Acute Toxicity (Oral): Category 5

Label Elements

Pictograms: None

Signal Word: Warning

Hazard Statements: H303 May be harmful if swallowed.

Precautionary Statements

Response: P312 Call a POISON CENTER or doctor/physician if you feel unwell.

Other Hazards

Not reported.

Section 3: Composition/Information on Ingredients

Substance/Mixture:

Pure substance

Ingredients:

Section 4: First-Aid Measures

First-Aid Measures for Different Exposure Routes

Inhalation: After inhalation: Move the victim to fresh air. Seek medical attention if symptoms persist.

Skin Contact: Under skin contact: Immediately remove all contaminated clothing. Rinse skin with water/shower.

Eye Contact: After eye contact: Rinse eyes with plenty of water. Remove contact lenses if present and easy to do.

Ingestion: After ingestion: Immediately give the victim water (up to 2 cups). Seek medical attention if feeling unwell.

Most Important Symptoms and Effects

For most important symptoms and effects, see Section 11.

Protection for First-Aid Providers

For personal protection, see Section 8.

Notes to Physician

No data available.

Section 5: Fire-Fighting Measures

Suitable Extinguishing Media

Water spray
Foam
Carbon dioxide (CO2)
Dry powder

Unsuitable Extinguishing Media

No restrictions on extinguishing agents for this substance or mixture.

Specific Hazards Arising from the Chemical

Combustible.

Fire may produce:

Hydrogen chloride gas
Nitrogen oxides

Section 6: Accidental Release Measures

Personal Precautions, Protective Equipment, and Emergency Procedures

For non-emergency personnel: Avoid dust inhalation. Evacuate the danger area, follow emergency procedures, and consult professional personnel.
For emergency responders: For personal protection, see Section 8.

Environmental Precautions

Do not allow product to enter drains.

Methods and Materials for Containment and Cleaning Up

Cover drains. Collect, absorb, and pump up spilled material. Comply with possible substance use restrictions (see Sections 7 and 10). Dry processing, dispose of as chemical waste, and clean the affected area. Avoid dust formation.

Section 7: Handling and Storage

Precautions for Safe Handling

Handling: See Section 2.2 for precautionary measures.

Conditions for Safe Storage, Including Any Incompatibilities

Storage: Keep container tightly closed. Keep dry.

Storage Conditions: Keep container tightly closed. Keep dry.

Storage Class: 11, Combustible solids

Recommended Storage Temperature: Refer to product label.

Further Information on Storage Stability: Storage temperature: Refer to product label.

Section 8: Exposure Controls/Personal Protection

Control Parameters

Occupational Exposure Limit Values for Components: No substances with occupational exposure limit values.

Biological Indicators

No substances with biological indicators.

Engineering Controls

No data available.

Personal Protective Equipment

Eye Protection: Use eye protection that complies with official standards such as NIOSH (USA) or EN 166 (EU). Safety glasses.

Skin Protection:

• Hand Protection:
  Material: Nitrile rubber
  Breakthrough Time: 480 min
  Glove Thickness: 0.11 mm
  Protection Index: Full contact
  Manufacturer: KCL 741 Dermatril® L
• Hand Protection:
  Material: Nitrile rubber
  Breakthrough Time: 480 min
  Glove Thickness: 0.11 mm
  Protection Index: Splash contact
  Manufacturer: KCL 741 Dermatril® L

Notes: The information provided here applies only to Merck products and the restrictions specified in the Safety Data Sheet. When mixed with other substances, dissolved, or in cases not covered by EN 16523-1, consult the glove manufacturer (e.g., KCL GmbH, Germany, website: www.kcl.de) for specific recommendations based on the application.

Hygiene Measures: Change contaminated clothing. Wash hands after using this substance.

Section 9: Physical and Chemical Properties

General Information

Appearance: Solid

Color: Colorless

Odor: Odorless

Odor Threshold: No data available.

pH Value: 5.0 - 6.5 (25 °C) at 140 g/l

Important Information on Physical and Chemical Properties

Melting Point: Approx. 200 °C (Approx. 1,013 hPa)
Method: OECD Test Guideline 102

Boiling Point: Approx. 300 °C (Approx. 1,013 hPa)
Method: OECD Test Guideline 103

Flash Point: Not applicable

Evaporation Rate: No data available.

Flammability (solid, gas): No data available.

Flammability (liquid): No data available.

Burning Rate: No data available.

Self-Ignition Temperature: 330 °C

Explosion Limits: No data available.

Vapor Pressure: No data available.

Vapor Density: No data available.

Relative Density: No data available.

Density: No data available.

Bulk Density: Approx. 430 kg/m3

Solubility:

• Water Solubility: 140 g/l

Partition Coefficient (n-octanol/water): log Pow: -3.77 (25 °C)
Method: OECD Test Guideline 123
Note: Estimated to have low bioaccumulation potential.

Decomposition Temperature: 355 °C
Method: DIN 51794

Viscosity: No data available.

Dynamic Viscosity: 26.2 mPa.s (20 °C)
Method: OECD Test Guideline 114
14.1 mPa.s (40 °C)
Method: OECD Test Guideline 114

Kinematic Viscosity: No data available.

Flow Time: No data available.

Explosive Properties: No data available.

Oxidizing Properties: None

Section 10: Stability and Reactivity

Reactivity

The following information applies to organic flammable substances and mixtures: When the concentration is high enough in a confined space, there is a risk of dust explosion.

Chemical Stability

The substance is chemically stable under standard atmospheric conditions (room temperature).

Possibility of Hazardous Reactions

May react violently with the following substances:
Strong oxidizing agents
Strong acids
Strong bases

Conditions to Avoid

No data available.

Incompatible Materials

No data available.

Hazardous Decomposition Products

On fire: See Section 5 Fire-Fighting Measures.

Section 11: Toxicological Information

11.1 Information on Toxicological Effects

Acute Toxicity:

• LD50 Oral - Mouse: 3,900 mg/kg
• Note: Sensory organs and special senses (nose, eyes, ears, and taste): Eyes: Tearing. Behavioral effects: Convulsions or effects on seizure threshold. Respiratory distress (RTECS)
• Inhalation: No data available.
• Dermal: No data available.

Skin Corrosion/Irritation:

• Skin - Rabbit: Result: No skin irritation - 20h
• Note: (ECHA)

Serious Eye Damage/Irritation:

• Eyes - Rabbit: Result: No eye irritation
• Note: (ECHA)

Respiratory or Skin Sensitization: No data available.

Germ Cell Mutagenicity:

• Test Type: Bacterial reverse mutation test (AMES)
• Test System: Salmonella typhimurium
• Metabolic Activation: With or without metabolic activation
• Method: OECD Test Guideline 471
• Result: Negative

• Test Type: Mutagenicity (mammalian cell test - chromosomal aberration test)
• Test System: Chinese hamster ovary cells
• Metabolic Activation: With or without metabolic activation
• Method: OECD Test Guideline 473
• Result: Negative

• Test Type: Sister chromatid exchange test
• Test System: Chinese hamster ovary cells
• Metabolic Activation: With or without metabolic activation
• Method: OECD Test Guideline 479
• Result: Negative

Carcinogenicity: No data available.

Reproductive Toxicity: No data available.

Specific Target Organ Toxicity - Single Exposure: No data available.

Specific Target Organ Toxicity - Repeated Exposure: No data available.

Aspiration Hazard: No data available.

Section 12: Ecological Information

11.2 Additional Information

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12.1 Ecotoxicity

Component: Choline chloride:

• Toxicity to Fish: LC50 (Leuciscus idus (Golden orfe)): > 10,000 mg/l
  Endpoint: Mortality
  Exposure Time: 96 h
  Test Type: Static test
  Method: German Standard Methods for the Examination of Water and Wastewater DIN 38412
• Toxicity to Aquatic Invertebrates: EC50 (Daphnia magna (water flea)): 500 mg/l
  Endpoint: Immobilization
  Exposure Time: 48 h
  Test Type: Static test
  Method: EU Regulation (EC) No 440/2008, Annex C.2
• Toxicity to Algae/Aquatic Plants: ErC50 (Desmodesmus subspicatus (narrow-leaf green algae)): > 500 mg/l
  Exposure Time: 72 h
  Test Type: Static test
  Method: German Standard Methods for the Examination of Water and Wastewater DIN 38412
• Toxicity to Aquatic Invertebrates (Chronic or Long-term Toxicity): NOEC (Daphnia magna (water flea)): 30.2 mg/l
  Endpoint: Reproduction rate
  Exposure Time: 21 d
  Test Type: Semi-static test
  Analytical Monitoring: Yes
  Method: OECD Test Guideline 211
  GLP Laboratory: Yes

Toxicity to Microorganisms: EC50 (Pseudomonas putida): 132.8 mg/l
Endpoint: Growth rate
Exposure Time: 17 h
Test Type: Static test
Method: German Standard Methods for the Examination of Water and Wastewater DIN 38 412 Part 8

Section 13: Disposal Considerations

Disposal Methods

Disposal of Waste: This product must be disposed of in accordance with waste disposal regulations. Disposal of waste must comply with national and local regulations. Store chemicals in their original containers and do not mix with other waste. Dispose of contaminated containers in the same manner as the product. Disposal of waste must comply with national and local regulations. Keep waste chemicals in their original containers and do not mix with other waste. Dispose of uncleaned containers in the same manner as the product.

Section 14: Transport Information

International Regulations

Air Transport (IATA-DGR):

• UN/ID Number: Not applicable
• UN Proper Shipping Name: Not applicable
• Transport Hazard Class(es): Not applicable
• Subsidiary Hazard Class(es): Not applicable
• Packing Group: Not applicable
• Label(s): Not applicable
• Packaging Instructions (Cargo Aircraft): Not applicable
• Packaging Instructions (Passenger Aircraft): Not applicable

Sea Transport (IMDG-Code):

• UN Number: Not applicable
• UN Proper Shipping Name: Not applicable
• Transport Hazard Class(es): Not applicable
• Subsidiary Hazard Class(es): Not applicable
• Packing Group: Not applicable
• Label(s): Not applicable
• EmS Number: Not applicable
• Marine Pollutant (Yes/No): No

According to the "MARPOL 73/78 Convention" Annex II and IBC Code, not applicable to the supplied product.

Section 15: Regulatory Information

Other Information

Special Transport Precautions and Notes: Not classified as dangerous goods according to transport regulations.

Applicable Regulations

• Occupational Safety and Health Act: Applicable
• Occupational Safety and Health Facility Regulations: Applicable
• Waste Disposal Act: Applicable
• Standards and Regulations for Storage and Disposal of Industrial Waste: Applicable
• Regulations on Hazardous Chemical Labeling and Communication: Not applicable
• Hazardous Chemical Assessment and Classification Management: No substances with occupational exposure limit values.
• Road Traffic Safety Rules: Not applicable
• Occupational Exposure Limits for Workplace: Not applicable
• Regulations for the Prevention of Organic Solvent Poisoning: Not applicable
• Regulations for the Prevention of Hazards from Specified Chemical Substances: Not applicable
• Standards and Safety Management Regulations for the Installation, Storage, and Handling of Public Dangerous Goods and Flammable High-Pressure Gases: Not applicable
• Management Regulations for Toxic and Concerned Chemical Substances: Not applicable
• Toxic Chemical Substances: Not applicable
• Concerned Chemical Substances: Not applicable
• Designation and Operation Management Regulations for Priority Management Chemicals: Not applicable

Section 16: Other Information

Further Information

References: For information on references, please refer to the respective chapters.

Prepared by/Contact Person

Name: Merck KGaA LS-QH Department

Address/Phone: 64271 Darmstadt Germany/+49 6151 72-0

Date of Preparation

2025.07.21

Other Information: The information in this document is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. The information in this document is based on our current knowledge and is applicable to the product as intended for safety precautions. This information does not constitute a guarantee of the entire properties of the product. Sigma-Aldrich Company and its affiliates shall not be liable for any damages arising from any handling or contact with the above product. For further terms of use, please refer to the reverse side of the invoice or packaging slip. For further sales terms and conditions, please see www.sigma-aldrich.com or the reverse side of the invoice or packing slip. Copyright: 2020 Sigma-Aldrich Co. LLC. Company. Paper copying is permitted without restriction, for internal use only.

Date Format: Year/Month/Day

Full Text of Other Abbreviations: AIIC - Australian Inventory of Industrial Chemicals; ANTT - Brazilian National Land Transport Agency; ASTM - American Society for Testing and Materials; bw - body weight; CMR - Carcinogenic, Mutagenic or Reprotoxic; DIN - German Institute for Standardization; DSL - Canada Domestic Substances List; ECx - Concentration of effect x%; ELx - Load of effect x%; EmS - Emergency Schedule; ENCS - Japan Existing and New Chemical Substances List; ErCx - Concentration of growth effect x%; ERG - Emergency Response Guidebook; GHS - Globally Harmonized System of Classification and Labelling of Chemicals; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Bulk Chemical Code; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - China Inventory of Existing Chemical Substances; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law of Japan; ISO - International Organization for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration 50%; LD50 - Lethal Dose 50%; MARPOL - International Convention for the Prevention of Pollution from Ships; Mercosur - Southern Common Market - Agreement on the transport of dangerous goods; n.o.s. - not otherwise specified; Nch - Chilean Certification; NO(A)EC - No Observed Adverse Effect Concentration; NO(A)EL - No Observed Adverse Effect Level; NOELR - No Observed Effect Level Rate; NOM - Mexican Safety Certification; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Prevention, Pesticides and Toxic Substances; PBT - Persistent, Bioaccumulative and Toxic; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - Quantitative Structure-Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TDG - Transport of Dangerous Goods; TECI - Thailand Existing Chemical Inventory; TSCA - Toxic Substances Control Act of the United States; UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - very Persistent and very Bioaccumulative; WHMIS - Workplace Hazardous Materials Information System.

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