Sodium Hydroxide Pellets EMPROVE® ESSENTIAL

1. Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name: Sodium hydroxide pellets EMPROVE® ESSENTIAL Ph Eur, BP,FCC,ChP,JP,NF,E 524

Product number: 1.06482

Catalog number: 106482

Brand: Millipore

Index-No.: 011-002-00-6

REACH No: 01-2119457892-27-XXXX

CAS-No.: 1310-73-2

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses: Pharmaceutical production and analysis

1.3 Details of the supplier of the safety data sheet

Company: BIOTECHA Eesti OÜ

Address: Liimi 1, 10621 TALLINN, ESTONIA

Email address: TechnicalService@merckgroup.com

1.4 Emergency telephone number

Emergency phone number: 10662 (Poison Control Center), +372 668 1294 (CHEMTREC)

Please contact your regional Merck representative.

2. Hazards identification

2.1 Classification of the substance or mixture

Classification (REGULATION (EC) No 1272/2008):

• Substances and mixtures which, in contact with water, emit flammable gases, Category 1: H290: May be corrosive to metals.
• Skin corrosion, Category 1A: H314: Causes severe skin burns and eye damage.
• Serious eye damage, Category 1: H318: Causes serious eye damage.

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008):

Hazard pictograms: (Corrosion symbol)

Signal word: Danger

Hazard statements:

• H290: May be corrosive to metals.
• H314: Causes severe skin burns and eye damage.

Precautionary statements:

• P234: Keep only in original packaging.
• P260: Do not breathe dust.
• P280: Wear protective gloves/ protective clothing/ eye protection/ face protection.

Response:

• P303 + P361 + P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
• P304 + P340 + P310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
• P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Additional hazard statements: None

2.3 Other hazards

The substance/mixture does not contain any components that are classified as persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) at a concentration of 0.1% or more.

Ecological information: The substance/mixture does not contain any components that are suspected of having endocrine-disrupting properties according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, at a concentration of 0.1% or more.

Information on toxicity: The substance/mixture does not contain any components that are suspected of having endocrine-disrupting properties according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, at a concentration of 0.1% or more.

3. Composition/information on ingredients

3.1 Substances

Chemical name: Sodium hydroxide

CAS-No.: 1310-73-2

EC No.: 215-185-5

Concentration (% w/w): >= 90 <= 100

Factor, SCL, ATE: Specific concentration limits:

• Skin Corr. 1A; H314: >= 5%
• Skin Corr. 1B; H314: 2-<5%
• Skin Irrit. 2; H315: 0.5 - < 2%
• Eye Irrit. 2; H319: 0.5 - < 2%
• Met. Corr. 1; H290: >= 0.4 %

4. First-aid measures

4.1 Description of first aid measures

General advice: The first aider must protect himself. Show this safety data sheet to the doctor.

If inhaled: Move to fresh air. Call a doctor.

In case of skin contact: Take off all contaminated clothing immediately. Rinse skin with water or shower. Call a doctor immediately.

If in eyes: Rinse with plenty of water.

If swallowed: Call a ophthalmologist immediately. Remove contact lenses. Rinse again.

4.2 Most important symptoms and effects, both acute and delayed

Most important symptoms and effects are described in the labelling (see section 2.2) or section 11.

4.3 Indication of any immediate medical attention and special treatment needed

No data available

5. Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media: Water spray, Alcohol-resistant foam, Dry powder, Carbon dioxide (CO2)

Unsuitable extinguishing media: Water jet

5.2 Special hazards arising from the substance or mixture

Principal hazards: Non-combustible. Hazardous decomposition products: Carbon oxides, Sodium oxides.

Hazardous combustion products: In the event of fire: hazardous decomposition products may be released. Hazardous decomposition products: Sodium oxides.

5.3 Advice for firefighters

Special protective equipment for firefighters: Wear self-contained breathing apparatus for firefighting. Wear full protective clothing.

Further advice: Cool container with water spray. Prevent fire-fighting water from entering surface water or groundwater. Contain runoff from fire control.

6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

For non-emergency personnel: Avoid breathing dust. Avoid contact with skin and eyes. Ensure adequate ventilation. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.

For emergency responders: Protective equipment: see section 8.2.

6.2 Environmental precautions

Environmental precautions: Do not let product enter drains. Prevent further leakage or spillage if safe to do so. Retain contaminated washing water and remove it from the drainage system.

6.3 Methods and material for containment and cleaning up

Methods for containment: Cover drains. Collect up spillage, bind it and pump it away.

Methods for cleaning up: Take up mechanically and collect in suitable containers for disposal. Clean up affected area. Avoid dust formation. Avoid breathing dust.

6.4 Reference to other sections

For disposal information see section 13.

7. Handling and storage

7.1 Precautions for safe handling

Hygiene measures: Immediately remove contaminated clothing. Wear protective gloves/protective clothing. Wash hands and face after working with the substance. Keep away from food, drink and animal feeding stuffs.

Precautions: See section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Requirements for storage places and containers: Do not store in aluminium, tin or zinc containers. Do not use metal containers.

Information on storage conditions: Keep container tightly closed. Keep dry.

German storage class (TRGS 510): 8B, non-combustible corrosive hazardous materials

Further information on storage conditions: Recommended storage temperature, see product label.

7.3 Specific end use(s)

Some uses are listed in section 1.2, other specific uses are not defined.

8. Exposure controls/personal protection

8.1 Control parameters

Occupational exposure limits:

8.2 Exposure controls

Eye/face protection: Use eye protection that is tested and approved according to EN 166(EU). Tight-fitting safety goggles.

Skin protection:

• Hand protection: Material: Nitrile rubber. Breakthrough time: 480 min. Glove thickness: 0.11 mm.

  KCL 741 Dermatril® L

• Hand protection: Material: Nitrile rubber. Breakthrough time: 480 min. Glove thickness: 0.11 mm.

  KCL 741 Dermatril® L

Remarks: This recommendation applies only to the product supplied by us for the intended use as specified in the safety data sheet. For dissolution or mixing in conditions different from those stated in EN 16523-1, please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Body protection: Protective clothing.

Respiratory protection: Required when dust is generated.

Our recommendations for respiratory protective equipment filters are based on the following standards: DIN EN 143, DIN 14387 and other relevant standards for respiratory protection systems.

Recommended filter type: P2 filter

The employer must ensure the maintenance, cleaning and proper documentation of respiratory protective equipment.

Environmental exposure controls: Do not let product enter drains.

9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

Physical state: Solid

Colour: White

Odour: Odourless

Odour threshold: Not applicable

Melting point: 318 °C

Boiling point: 1.390 °C (1.013 hPa)

Flash point: Not applicable

Evaporation rate: Not applicable

Flammability (solid, gas): Product is not flammable.

Upper/lower flammability or explosive limits: Not applicable

Vapour pressure: Not applicable

Vapour density: Not applicable

Relative density: 1.38 (Air = 1.0)

Density: 2.13 g/cm3 (20 °C)

Bulk density: Not applicable

Solubility(ies):

• Water solubility: 1.090 g/l (20 °C)

Partition coefficient: n-octanol/water: Not applicable for inorganic substances

Auto-ignition temperature: Not applicable

Decomposition temperature: No data available

pH: ca. > 14 (20°C) Concentration: 100 g/l

Viscosity, dynamic: No data available

Viscosity, kinematic: No data available

Explosive properties: Not classified as an explosive substance.

Oxidising properties: None

Corrosion to metals: May be corrosive to metals.

Particle characteristics: No data available

9.2 Other information

Molecular mass: 40 g/mol

10. Stability and reactivity

10.1 Reactivity

No data available

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (at room temperature).

10.3 Possibility of hazardous reactions

Hazardous reactions: Possible vigorous reaction with the following:

• Acetone
• Chlorine
• Ethylene oxide
• Fluorine
• Hydrogen halides
• Hydrazine hydrate
• Hydroxylamine
• Acid anhydrides
• Acrolein
• Acid chlorides
• Acids
• Sulfuric acid
• Chloroform
• Water
• Hydrogen peroxide
• Anhydrides
• Phosphides
• Halogen-halogen compounds
• Trichloroethylene

May decompose violently when in contact with the following:

• Organic substances
• Hydrogen sulfide

Risk of ignition or formation of flammable gases or vapours in contact with:

• Powdered aluminum
• Ammonium salts
• Persulfates
• Sodium borohydride
• Phosphorus
• Phosphorus oxides
• Halogenated hydrocarbons
• Light metals
• Metals

Risk of explosion or exothermic reaction on contact with the following:

• Bromine
• Calcium
• Powdered form
• Furfuryl alcohol
• Nitromethane
• Peroxides
• Organic nitro compounds
• Nitriles
• Acrylonitrile
• Chloroform
• together with
• Acetone
• Nitrobenzene
• together with
• Methanol
• Nitrobenzene
• together with
• salts
• magnesium
• Zinc
• and
• Tin
• (in the presence of air humidity and/or moisture)

10.4 Conditions to avoid

Conditions to avoid: Information not available

10.5 Incompatible materials

Incompatible materials: No data available

10.6 Hazardous decomposition products

Hazardous decomposition products: In case of fire: see section 5.

11. Toxicological information

11.1 Information on toxicological effects

Acute toxicity:

Symptoms: Ingestion causes burns to the mouth and throat, and perforation of the stomach and esophagus. Symptoms: Mucous membrane irritation, Cough, Breathing difficulty, Possible damage to: respiratory tract damage.

Skin: No data available

Skin corrosion/irritation:

• Skin - Rabbit: Result: Causes corrosion.

Serious eye damage/eye irritation:

• Eyes - Rabbit: Result: Causes serious eye damage. (OECD Test Guideline 405)

Respiratory or skin sensitisation:

• Test: Skin sensitisation - In vitro study
• Result: Negative
• Remarks: (ECHA)

Germ cell mutagenicity: No data available

Carcinogenicity: No data available

Reproductive toxicity: No data available

STOT-single exposure: No data available

STOT-repeated exposure: No data available

Aspiration hazard: No data available

11.2 Further information

Endocrine disrupting properties:

• Product:
• Assessment: The substance/mixture does not contain any components that are suspected of having endocrine-disrupting properties according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, at a concentration of 0.1% or more.

No other hazardous properties can be excluded.

12. Ecological information

12.1 Toxicity

Component(s), where applicable:

• Sodium hydroxide:
• Toxicity to fish: LC50 (Gambusia affinis (Mosquito fish)): 125 mg/l. Exposure time: 96 h. Remarks: (ECOTOX database).
• Toxicity to daphnia and other aquatic invertebrates: EC50 (Ceriodaphnia (water flea)): 40.4 mg/l. Endpoint: Immobilisation. Exposure time: 48 h. Remarks: (ECHA).
• Toxicity to microorganisms: EC50 (Photobacterium phosphoreum (Bacterium)): 22 mg/l. Exposure time: 15 min. Remarks: (external material safety data sheet).

Ecotoxicological assessment: No known ecotoxicological effects of the product.

12.2 Persistence and degradability

Component(s), where applicable:

• Sodium hydroxide:
• Biodegradability: Biodegradation methods are not suitable for inorganic substances.

12.3 Bioaccumulative potential

Component(s), where applicable:

• Sodium hydroxide:
• Partition coefficient: n-octanol/water: Not applicable for inorganic substances.

12.4 Mobility in soil

No data available

12.5 Persistence, bioaccumulative and toxic properties for substances and mixtures

Product:

• Assessment: The substance/mixture does not contain any components that are classified as persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) at a concentration of 0.1% or more.

Component(s), where applicable:

• Sodium hydroxide:
• Assessment: PBT/vPvB: Not applicable for inorganic substances.

12.6 Endocrine disrupting properties

Product:

• Assessment: The substance/mixture does not contain any components that are suspected of having endocrine-disrupting properties according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, at a concentration of 0.1% or more.

12.7 Other adverse effects

Component(s), where applicable:

• Sodium hydroxide:
• Ecological information: Harmful effect due to pH change. Even when diluted, it forms corrosive mixtures with water. Neutralization is possible in wastewater treatment plants. Avoid release to the environment.

13. Disposal considerations

13.1 Waste treatment methods

Product: Waste must be disposed of in accordance with national and local regulations. Keep chemicals in their original containers. Keep separate from other waste. Treat uncleaned containers as the product itself. For information on waste directive 2008/98/EC, please refer to it.

14. Transport information

14.1 UN number or ID number

• ADR: UN 1823
• IMDG: UN 1823
• IATA: UN 1823

14.2 UN proper shipping name

• ADR: SODIUM HYDROXIDE, SOLID
• IMDG: SODIUM HYDROXIDE, SOLID
• IATA: Sodium hydroxide, solid

14.3 Transport hazard class(es)

• ADR: Class 8
• IMDG: Class 8
• IATA: Class 8

14.4 Packing group

• ADR: Packing group II
• Classification code: C6
• Hazard identification number: 80
• Marking: 8
• IMDG: Packing group II
• Marking: 8
• EmS Code: F-A, S-B
• IATA (Cargo): Packing instructions: 863. Packing instruction LQ: Y844. Packing group: II. Marking: Class 8 - Corrosive substances.
• IATA (Passenger): Packing instructions: 859. Packing instruction LQ: Y844. Packing group: II. Marking: Class 8 - Corrosive substances.

14.5 Environmental hazards

• ADR: Not environmentally hazardous
• IMDG: Marine pollutant: No

14.6 Special precautions for user

The transport classifications provided herein are for informational purposes only and are based on the properties of the unpacked material as described in this safety data sheet.

14.7 Transport in bulk according to Annex II of MARPOL and the IBC Code

Not applicable to the product supplied.

15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

• REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII): Not applicable
• REACH - Candidate List of Substances of Very High Concern (Article 59): Not applicable
• Regulation (EC) No 2024/590 on substances that deplete the ozone layer: Not applicable
• Regulation (EU) 2019/1021 on persistent organic pollutants (recast): Not applicable
• REACH - List of Substances subject to authorisation (Annex XIV): Not applicable
• Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances, and amending Council Directive 96/82/EC and its subsequent repeal: Not applicable

Other regulations: Comply with the requirements of Directive 94/33/EU on the protection of young people at work or the strictest national regulations, where applicable.

15.2 Chemical safety assessment

A chemical safety assessment has been carried out for this chemical.

16. Other information

16.1 Full text of H-Statements referred to under sections 2 and 3

EE OEL: Occupational exposure limit values for chemical agents.

EE OEL / Limit value: Average content of the chemical substance in inhaled air during the working day or working week.

EE OEL / Short-term exposure limit: Maximum permissible average content of the chemical substance in inhaled air for 15 minutes.

ADN: European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - European Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for Testing and Materials; bw - Body weight; CLP - Classification, Labelling and Packaging of substances and mixtures; DIN - German Institute for Standardization; DSL - Domestic Substances List (Canada); ECHA - European Chemicals Agency; EC-Number - European Community number; ECx - Concentration of a stimulus causing a response; ELx - Loading rate causing a response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration of a stimulus causing a response; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods Code; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organization for Standardization; KECI - Korean Existing Chemicals Inventory; LC50 - Lethal Concentration to 50% of test population; LD50 - Median lethal dose to 50% of test population; MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not otherwise specified; NO(A)EC - Not applicable (or no effects observed) concentration; NO(A)EL - Not applicable (or no effects observed) level; NOELR - Not applicable (or no observed effect) loading rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippine Inventory of Chemicals and Chemical Substances; (Q)SAR - Quantitative Structure-Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; SVHC - Substance of Very High Concern; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand Existing Chemicals Inventory; TRGS - Technical Rules for Hazardous Substances; TSCA - Toxic Substances Control Act (USA); UN - United Nations; vPvB - very Persistent and very Bioaccumulative substance.

Further information: The information provided in this document is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. The information in this document is based on our current knowledge and is applicable to the product with regard to the relevant safety measures. It does not represent any guarantee of the product's properties. Sigma-Aldrich Co. shall not be held liable for any damage resulting from the handling or contact with the above product. For further terms of sale, please see the back of the invoice or the package leaflet.

Copyright 2020 Sigma-Aldrich Co. LLC. Permission is granted to make unlimited paper copies for internal use only.

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