Safety Data Sheet

1. Chemical Product and Company Identification

1.1 Product Identification

Chemical Name: Magnesium oxide heavy EMPROVE® ESSENTIAL Ph Eur, BP, ChP, USP

Product Number: 1.05867

Item Number: 105867

Brand: Millipore

1.2 Other Names

No data available.

1.3 Recommended Use and Restrictions on Use

Recommended Use: Pharmaceutical production and analysis.

1.4 Details of the Supplier of the Safety Data Sheet

Manufacturer, Importer, or Supplier: Taiwan Merck Co., Ltd.

Name, Address, and Phone Number: 20F, No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, TAIWAN

MERCK LTD.

20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, Taiwan

Merck KGaA

64271 Darmstadt, Germany

Phone: +49 6151 72-0

Phone: +886 2-2162-1111

Fax: +886 2-8751-6262

1.5 Emergency Contact Information

Emergency Phone Number: CHEMTREC: 00801 49 1821, CHEMTREC Taipei: +886 2 7741 4207

2. Hazard Identification Information

2.1 Hazard Classification of Chemical Products

Not a hazardous substance or mixture.

2.2 Label Content

No hazard pictograms, signal words, hazard statements, or hazard prevention measures are required.

2.3 Other Hazards

No reports.

3. Composition/Information on Ingredients

3.1 Substance/Mixture:

Substance

3.2 Components:

4. First-Aid Measures

4.1 First-Aid Measures for Different Exposure Routes

Inhalation: Move the exposed person to fresh air. If breathing is difficult, administer oxygen. If breathing has stopped, give artificial respiration. Seek medical attention.

Skin Contact: Immediately remove all contaminated clothing. Wash skin with soap and water or rinse with plenty of water. Seek medical attention if irritation persists.

Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Rinse mouth with water. Never give anything by mouth to an unconscious person. Seek medical attention.

4.2 Most Important Symptoms and Effects

See Section 11 for the most important symptoms and effects.

4.3 Protection for First-Aid Responders

See Section 8 for personal protection.

4.4 Notes to Physician

No data available.

5. Fire-Fighting Measures

5.1 Suitable Extinguishing Media:

Use extinguishing measures that are appropriate to the surrounding environment and the fire situation.

5.2 Unsuitable Extinguishing Media:

No restrictions on extinguishing agents for this substance or mixture.

5.3 Special Hazards Arising from the Substance or Mixture:

Non-combustible. Hazardous vapors may be released if exposed to fire.

5.4 Hazardous Combustion Products:

Magnesium oxide

5.5 Special Fire-Fighting Procedures:

Prevent fire-fighting water from entering surface water and groundwater systems.

5.6 Special Protective Equipment for Firefighters:

Wear self-contained breathing apparatus when fighting a fire.

6. Accidental Release Measures

6.1 Personal Precautions, Protective Equipment, and Emergency Procedures:

For non-emergency personnel: Avoid dust inhalation. Evacuate the danger area, follow emergency procedures, and consult with professional personnel.

For emergency responders: See Section 8 for personal protection.

6.2 Environmental Precautions:

Do not allow product to enter drains.

6.3 Methods and Materials for Containment and Cleaning Up:

Cover drains. Collect, absorb, and pump leaked material. Observe any material use restrictions (see Sections 7 and 10). Dry cleanup, dispose of as chemical waste, and clean affected areas. Avoid dust generation.

7. Handling and Storage

7.1 Precautions for Safe Handling:

Follow safety precautions as described in Section 2.2.

7.2 Conditions for Safe Storage, Including Any Incompatibilities:

Storage: Keep container tightly closed. Keep dry.

Storage Class: 13, Non-combustible solids.

Recommended Storage Temperature: Refer to product label.

Further Information on Storage Stability: Refer to product label.

8. Exposure Controls/Personal Protection

8.1 Control Parameters for the Workplace:

8.2 Biological Indicators:

Does not contain substances with biological indicators.

8.3 Engineering Controls:

No data available.

8.4 Personal Protective Equipment:

Respiratory Protection: Required when dust is generated. Recommendations for filtering respiratory protective devices will be based on standards such as DIN EN 143, DIN 14387, and other relevant standards for respiratory protective devices. Recommended filter type: P1.

Company managers must maintain, clean, and test respiratory protective equipment according to the manufacturer's instructions and keep proper records of these measures.

Hand Protection:

• Material: Nitrile rubber
• Solvent Permeation Time: 480 minutes
• Glove Thickness: 0.11 mm
• Protection Index: Full contact
• Manufacturer: KCL 741 Dermatril® L

Hand Protection:

• Material: Nitrile rubber
• Solvent Permeation Time: 480 minutes
• Glove Thickness: 0.11 mm
• Protection Index: Splash contact
• Manufacturer: KCL 741 Dermatril® L

Notes: The information provided here is only applicable to Merck products and their specified uses in the Safety Data Sheet. When mixing with other substances, dissolving, or in situations not covered by EN 16523-1, please contact the CE-certified glove supplier (e.g., German glove supplier KCL, website: www.kcl.de).

Eye Protection: Use eye protection equipment tested and approved according to official standards such as NIOSH (USA) or EN 166 (EU).

Hygiene Measures: Change contaminated clothing. Wash hands after using this substance.

9. Physical and Chemical Properties

9.1 Appearance:

Form: Solid

Color: White

9.2 Odor:

No data available.

9.3 Odor Threshold:

No data available.

9.4 pH Value:

No data available.

9.5 Melting Point:

2,852 °C

9.6 Boiling Point:

3,600 °C (1,013.25 HPA)

9.7 Flash Point (Test Method):

Not applicable.

9.8 Evaporation Rate:

No data available.

9.9 Flammability (Solid, Gas):

This product is not flammable.

9.10 Flammability (Liquid):

No data available.

9.11 Burning Rate:

No data available.

9.12 Upper/Lower Flammability or Explosive Limits:

No data available.

9.13 Upper/Lower Explosive Limits:

No data available.

9.14 Vapor Pressure:

No data available.

9.15 Vapor Density:

No data available.

9.16 Relative Density:

No data available.

9.17 Density:

3.580 g/cm3

9.18 Bulk Density:

Approximately 100 kg/m3

9.19 Solubility:

Water Solubility: Insoluble

Solubility in Other Solvents: Not applicable for inorganic substances.

9.20 Partition Coefficient (n-octanol/water):

Not applicable.

9.21 Auto-ignition Temperature:

Not applicable.

9.22 Decomposition Temperature:

No data available.

9.23 Dynamic Viscosity:

No data available.

9.24 Kinematic Viscosity:

No data available.

9.25 Flow Time:

No data available.

9.26 Explosive Properties:

No data available.

9.27 Oxidizing Properties:

No.

9.28 Molecular Weight:

40.31 g/mol

9.29 Particle Characteristics:

Particle Size: No data available.

10. Stability and Reactivity

10.1 Reactivity:

No data available.

10.2 Chemical Stability:

The product is chemically stable under standard atmospheric conditions (room temperature).

10.3 Possibility of Hazardous Reactions:

Exothermic reactions may occur with the following substances:

• Halogen-halogen compounds
• Acids
• Phosphorus pentachloride

Explosive hazard may occur with the following substances:

• Aluminum powder

10.4 Conditions to Avoid:

Sensitive to air.

10.5 Incompatible Materials:

No data available.

10.6 Hazardous Decomposition Products:

When ignited: See Section 5 Fire-Fighting Measures.

11. Toxicological Information

11.1 Information on Toxicological Effects:

Acute Toxicity:

• Oral: No data available.
• Inhalation: No data available.
• Dermal: No data available.

Skin Corrosion/Irritation:

Notes: No data available.

Serious Eye Damage/Irritation:

Notes: No data available.

Respiratory or Skin Sensitization:

No data available.

Germ Cell Mutagenicity:

No data available.

Carcinogenicity:

No data available.

Reproductive Toxicity:

No data available.

Specific Target Organ Toxicity - Single Exposure:

No data available.

Specific Target Organ Toxicity - Repeated Exposure:

No data available.

Aspiration Hazard:

No data available.

11.2 Additional Information:

Large amounts ingested or inhaled may cause inflammatory reactions and leukocytosis. Diarrhea. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. Ecological Information

12.1 Ecotoxicity:

No data available.

12.2 Persistence and Degradability:

Composition:

Magnesium oxide:

• Biodegradability: Notes: Biodegradability test methods are not applicable to inorganic substances.

12.3 Bioaccumulative Potential:

Composition:

Magnesium oxide:

• Octanol/water partition coefficient: Notes: Not applicable to inorganic substances.

12.4 Mobility in Soil:

No data available.

12.5 Other Adverse Effects:

No data available.

13. Disposal Considerations

13.1 Waste Treatment Methods:

Residue/Unused Product: Disposal of waste must comply with national and local regulations. Keep chemical waste in its original container and do not mix with other waste. Dispose of contaminated containers in the same manner as the product.

The product must be cleaned according to the waste disposal law. Disposal of waste must comply with national and local regulations. Store chemical waste in its original container and do not mix with other waste. Dispose of contaminated containers in the same manner as the product.

14. Transport Information

14.1 UN Number:

Not applicable.

14.2 UN Proper Shipping Name:

Not applicable.

14.3 Transport Hazard Class(es):

Not applicable.

14.4 Packing Group:

Not applicable.

14.5 Environmental Hazards:

Not applicable.

14.6 Special Precautions for User:

According to transport regulations, it is not classified as a dangerous good.

15. Regulatory Information

15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance or Mixture:

Occupational Safety and Health Act: Applicable

Occupational Safety and Health Facility Rules: Applicable

Waste Disposal Act: Applicable

Standards and Regulations for Storage and Disposal of Industrial Waste: Not a hazardous or toxic substance.

Hazardous Chemical Labeling and Communication Rules: Not applicable.

Hazardous Chemical Assessment and Classification Management: Applicable

Road Traffic Safety Rules: Not applicable.

Permissible Exposure Standards for Working Places: Not applicable.

Prevention of Organic Solvent Poisoning Rules: Not applicable.

Prevention of Specific Chemical Substance Hazards Rules: Not applicable.

Management Law for Toxic and Concerned Chemicals:

• Toxic Chemicals: Not applicable.
• Concerned Chemicals: Not applicable.

Designation and Operation Management Rules for Priority Management Chemicals: Not applicable.

16. Other Information

16.1 Further Information:

References: Please refer to the relevant sections for information on references.

The information in this document is based on our current knowledge and is intended to provide guidance on the safe handling of this product. This information does not represent a guarantee of all properties of this product. Users should independently determine its suitability based on their application needs. Merck does not provide any warranty for this product.

16.2 Preparer/Preparer's Name:

Name: Merck KGaA LS-QH Department

Address/Phone: 64271 Darmstadt Germany/+49 6151 72-0

16.3 Date of Preparation:

2025.07.22

16.4 Other Information:

The information provided is believed to be accurate but does not contain all information and is intended for guidance only. The information in this document is based on our current knowledge and is intended to provide guidance on the safe handling of this product. This information does not represent a guarantee of all properties of this product. Sigma-Aldrich and its affiliates are not liable for any damages arising from the handling or contact with the above-mentioned product. For more terms of use, please refer to the back of the invoice or packaging slip. For more sales terms and conditions, please refer to www.sigma-aldrich.com.

Abbreviations and Acronyms:

• ACGIH: American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Values (TLV)
• TW OEL: Workplace Exposure Limit in Taiwan
• ACGIH / TWA: 8-hour Time-Weighted Average
• TW OEL / TWA: 8-hour Time-Weighted Average Exposure Limit
• TW OEL / STEL: Short-Term Exposure Limit

AIIC: Australian Inventory of Industrial Chemicals; ANTT: Brazilian National Land Transport Agency; ASTM: American Society for Testing and Materials; bw: body weight; CMR: Carcinogenic, Mutagenic, or Reprotoxic substances; DIN: German Institute for Standardization; DSL: Canada Domestic Substances List; ECx: Concentration of effect causing x% response; ELx: Effect concentration causing x% response; EmS: Emergency Schedule; ENCS: Japan Existing and New Chemical Substances List; ErCx: Concentration of effect causing x% growth response; ERG: Emergency Response Guidebook; GHS: Globally Harmonized System of Classification and Labelling of Chemicals; GLP: Good Laboratory Practice; IARC: International Agency for Research on Cancer; IATA: International Air Transport Association; IBC: International Bulk Chemical Code; IC50: Half maximal inhibitory concentration; ICAO: International Civil Aviation Organization; IECSC: China Inventory of Existing Chemical Substances; IMDG: International Maritime Dangerous Goods; IMO: International Maritime Organization; ISHL: Industrial Safety and Health Act of Japan; ISO: International Organization for Standardization; KECI: Korea Existing Chemicals List; LC50: Lethal Concentration 50%; LD50: Lethal Dose 50%; MARPOL: International Convention for the Prevention of Pollution from Ships; MERCOSUR: Southern Common Market - Agreement on the Transport of Dangerous Goods; n.o.s.: not otherwise specified; Nch: Chilean Certification; NO(A)EC: No Observed Adverse Effect Concentration; NO(A)EL: No Observed Adverse Effect Level; NOELR: No Observed Effect Loading Rate; NOM: Mexican Official Standard; NTP: National Toxicology Program; NZIoC: New Zealand Inventory of Chemicals; OECD: Organisation for Economic Co-operation and Development; OPPTS: Office of Prevention, Pesticides and Toxic Substances; PBT: Persistent, Bioaccumulative and Toxic; PICCS: Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR: Quantitative Structure-Activity Relationship; REACH: Registration, Evaluation, Authorisation and Restriction of Chemicals (EC) No 1907/2006; SADT: Self-Accelerating Decomposition Temperature; SDS: Safety Data Sheet; TCSI: Taiwan Chemical Substance Inventory; TDG: Transport of Dangerous Goods; TECI: Thailand Inventory of Chemical Substances; TSCA: Toxic Substances Control Act of the United States; UN: United Nations; UNRTDG: United Nations Recommendations on the Transport of Dangerous Goods; vPvB: very Persistent and very Bioaccumulative; WHMIS: Workplace Hazardous Materials Information System.

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