Safety Data Sheet

Product Identification

• Product Name: Tween® 80 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JP,NF
• Product Number: 8.17061
• Catalog Number: 817061
• Brand: Millipore
• REACH No.: Registration number not available as the substance or its use is not subject to registration, or the annual tonnage does not require registration.
• CAS No.: 9005-65-6

Identified Uses and Uses Advised Against

• Identified Uses: Laboratory chemicals, Manufacture of substances

Supplier Information

• Company: BIOTECHA Eesti OÜ
• Address: Liimi 1, 10621 TALLINN, ESTONIA
• Email: TechnicalService@merckgroup.com

Emergency Telephone Number

• Emergency Phone: 16662 (Poison Control Center), +372 668 1294 (CHEMTREC)
• Please contact your local Merck representative for assistance.

Hazards Identification

• Classification: Not classified as a hazardous substance or mixture according to Regulation (EC) No 1272/2008.
• Label Elements: No hazard pictograms, signal words, hazard statements, or precautionary statements are required according to Regulation (EC) No 1272/2008.
• Other Hazards: The substance/mixture does not contain components considered persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or more. The substance/mixture does not contain components that are suspected of causing environmental endocrine disruption according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605 at levels of 0.1% or more.

Composition/Information on Ingredients

• Substances:
• CAS No.: 9005-65-6
• Components: No hazardous ingredients.

First-Aid Measures

• Inhalation: Move person to fresh air.
• Skin Contact: Take off all contaminated clothing immediately. Wash skin with plenty of water/shower.
• Eye Contact: Rinse thoroughly with plenty of water. Remove contact lenses if present and easy to do.
• Ingestion: Rinse mouth. Give water to drink (up to two glasses). If feeling unwell, consult a doctor.
• Symptoms and Effects: Refer to Section 2.2 or Section 11 for known symptoms and effects.
• Medical Attention: Information not available.

Fire-Fighting Measures

• Extinguishing Media: Water, Foam, Carbon dioxide (CO2), Dry powder.
• Unsuitable Extinguishing Media: None specified.
• Specific Hazards: Combustible. Vapors are heavier than air and may accumulate on the ground. May form explosive mixtures with air on strong heating. Hazardous decomposition products may form during fire. The nature of unknown decomposition products is not specified.
• Protective Equipment: Firefighters should wear self-contained breathing apparatus.
• Additional Information: Avoid contamination of surface water and groundwater with fire-fighting water.

Accidental Release Measures

• Personal Precautions: Advise non-emergency personnel. Avoid breathing vapors and aerosols. Refer to Section 8 for protective measures. Evacuate the danger area, follow emergency procedures, and consult an expert.
• Environmental Precautions: Do not allow product to enter drains.
• Containment and Cleaning: Cover drains. Collect spilled material, absorb, and pump away. Observe any material restrictions (see Sections 7 and 10). Collect and remove with a liquid absorbent (e.g., Chemizorb®). Dispose of properly. Clean the contaminated area. Refer to Section 13 for disposal instructions.

Handling and Storage

• Precautions for Safe Handling: Take off contaminated clothing. Wash hands after working with the substance. Refer to Section 2.2 for precautions.
• Conditions for Safe Storage: Keep tightly closed.
• Storage Class (TRGS 510): 10, Flammable liquid.
• Additional Information: Recommended storage temperature as indicated on the product label.

Exposure Controls/Personal Protection

• Exposure Limits: No substances with established occupational exposure limits are present.
• Personal Protective Equipment:
• Eye/Face Protection: Use eye protection that is tested and approved according to EN 166(EU). Safety glasses.
• Hand Protection:
• Material: Nitrile rubber.
• Breakthrough time: 480 min.
• Glove thickness: 0.4 mm.
• Index of protection: Full contact.
• Manufacturer: Camatril® (KCL 730 / Aldrich Z677442, size M).
• Material: Nitrile rubber.
• Breakthrough time: 30 min.
• Glove thickness: 0.11 mm.
• Index of protection: Splash contact.
• Manufacturer: KCL 741 Dermatril® L.
• Notes: This recommendation applies only to the product supplied for its intended use and as stated in the safety data sheet. For dissolution or mixing under conditions different from those specified in EN 16523-1, please contact the CE-approved glove supplier (e.g., KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
• Respiratory Protection: Not required, except when aerosols are generated.
• Environmental Exposure Control: Do not allow product to enter drains.

Physical and Chemical Properties

• Physical State: Liquid
• Color: Yellow
• Odor: Data not available.
• Melting Point: Data not available.
• Boiling Point: Data not available.
• Flash Point: > 113 °C (Closed cup)
• Ignition Temperature: Data not available.
• Decomposition Temperature: Data not available.
• pH: Data not available.
• Viscosity:
• Dynamic Viscosity: Data not available.
• Kinematic Viscosity: 300 - 500 mm²/s (25 °C)
• Solubility: Soluble in water.
• Partition Coefficient (n-octanol/water): Data not available.
• Vapor Pressure: < 1.33 hPa (20 °C)
• Density: 1.06 - 1.09 g/cm³ (25 °C)
• Relative Vapor Density: Data not available.
• Particle Characteristics: Data not available.
• Other Information: Not classified as an explosive substance. No oxidizing properties. Flammability rate and evaporation rate data not available.

Stability and Reactivity

• Reactivity: May form explosive mixtures with air on strong heating. Critical range is approximately 15 Kelvin below the flash point.
• Chemical Stability: The product is chemically stable under standard ambient conditions (room temperature).
• Possibility of Hazardous Reactions: Possible violent reaction with strong oxidizing agents.
• Conditions to Avoid: Strong heating.
• Incompatible Materials: Strong oxidizing agents.
• Hazardous Decomposition Products: See Section 5.

Toxicological Information

• Acute Toxicity:
• Oral LD50 (Rat): 34,500 mg/kg. Remarks: (RTECS)
• Inhalation: Data not available.
• Dermal: Data not available.
• Skin Corrosion/Irritation:
• Skin - Rabbit: Result: Does not cause skin irritation. Remarks: (external material safety data sheet)
• Serious Eye Damage/Irritation:
• Eyes - Rabbit: Result: Does not cause eye irritation. Remarks: (external material safety data sheet)
• Respiratory or Skin Sensitization: Data not available.
• Germ Cell Mutagenicity: Data not available.
• Test Type: Ames test.
• Test System: Salmonella typhimurium.
• Result: Negative. Remarks: (National Toxicology Program).
• Test Type: Mutagenicity (mammalian cell test).
• Result: Negative. Remarks: (National Toxicology Program).
• Carcinogenicity: This product or its components are not classified as carcinogenic based on IARC, ACGIH, NTP, or EPA classifications.
• Reproductive Toxicity: Data not available.
• STOT-Single Exposure: Data not available.
• STOT-Repeated Exposure: Data not available.
• Aspiration Hazard: Data not available.
• Endocrine Disrupting Properties: The substance/mixture does not contain components suspected of causing environmental endocrine disruption according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605 at levels of 0.1% or more. The chemical, physical, and toxicological properties have not been thoroughly investigated.

Ecological Information

• Toxicity: Data not available.
• Persistence and Degradability: Data not available.
• Bioaccumulative Potential: Data not available.
• Mobility in Soil: Data not available.
• PBT and vPvB Assessment: The substance/mixture does not contain components considered persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or more.
• Endocrine Disrupting Properties: The substance/mixture does not contain components suspected of causing environmental endocrine disruption according to Article 57(f) of REACH, Commission Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605 at levels of 0.1% or more.
• Other Adverse Effects: Data not available.

Disposal Considerations

• Waste Treatment Methods: Waste must be handled in accordance with national and local regulations. Keep chemicals in their original containers. Keep separate from other waste. Uncleaned containers should be treated as the product itself. For reference, Waste Directive 2008/98/EC.

Transport Information

• UN Number: Not classified as dangerous goods.
• UN Proper Shipping Name: Not classified as dangerous goods.
• Transport Hazard Class(es): Not classified as dangerous goods.
• Packing Group: Not classified as dangerous goods.
• Environmental Hazards: Not classified as dangerous goods.
• Special Precautions: According to transport regulations, it is not classified as a dangerous substance.
• Bulk Transport: Not applicable for the supplied product.

Regulatory Information

• Applicable Safety, Health, and Environmental Regulations:
• REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII): Not applicable.
• REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59): Not applicable.
• Regulation (EU) No 2024/590 on substances that deplete the ozone layer: Not applicable.
• Regulation (EL) 2019/1021 on persistent organic pollutants (recast): Not applicable.
• REACH - List of Substances subject to Authorisation (Annex XIV): Not applicable.
• Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances, and amending Council Directive 96/82/EC, and its repeal: Not applicable.
• Chemical Safety Assessment: A chemical safety assessment has not been carried out for the substance.

Other Information

• Full text of abbreviations: ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - European Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for Testing and Materials; bw - body weight; CLP - Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures; CMR - Carcinogenic, Mutagenic or Toxic to Reproduction; DIN - German Institute for Standardization; DSL - Domestic Substances List (Canada); ECHA - European Chemicals Agency; EC Number - European Community number; ECx - Concentration of response from X%; ELx - Loading rate of response from X%; EmS - Emergency Schedules; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration of response from X% in growth rate; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships Carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods Code; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organization for Standardization; KECI - Korean Existing Chemicals Inventory; LC50 - Lethal concentration to 50% of test population; LD50 - Lethal dose to 50% of test population (Median lethal dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - not otherwise specified; NO(A)EC - Not otherwise specified (effect) concentration; NO(A)EL - Not otherwise specified (effect) level; NOELR - Not otherwise specified (effect) loading rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic; PICCS - Philippine Inventory of Chemicals and Chemical Substances; (Q)SAR - Quantitative Structure-Activity Relationship; REACH - Regulation (EC) No 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; SVHC - Substance of Very High Concern; TCSI - Taiwan Chemical Substance Inventory; TECI - Taiwan Existing Chemicals Inventory; TRGS - Technical Rules for Hazardous Substances; TSCA - Toxic Substances Control Act (USA); UN - United Nations; vPvB - very Persistent and very Bioaccumulative.
• Further Information: The information provided is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. The information in this document is based on the level of knowledge of our current information and is applicable to the product in relation to the relevant safety measures. It does not constitute any guarantee of the product's properties. Sigma-Aldrich Co. is not liable for any damages resulting from the handling of or contact with the product mentioned above. For additional terms of sale, see the reverse of the invoice or packing slip. Copyright 2020 Sigma-Aldrich Co. LLC. Permission is granted to make unlimited paper copies for internal use only. The labeling in the header and/or footer of this document may not visually match your purchased product temporarily, as we are in the process of updating the labeling. However, the information provided in this document about the product remains unchanged and corresponds to your ordered product. For further information, please contact mlsbranding@sial.com. EE / ET