Safety Data Sheet

Section 1: Chemical Product and Company Identification

1.1 Product Identification

Chemical Name: 1,2-Propanediol EMPROVE® EXPERT Ph Eur, BP, USP

Product Code: 1.07478

Item Number: 107478

Brand: Millipore

1.2 Other Names

No data available.

1.3 Use of the Substance/Mixture and Recommended Restrictions

Recommended Use: Pharmaceutical production and analysis

1.4 Details of the Supplier of the Safety Data Sheet

Manufacturer, Importer, or Supplier: Merck Taiwan Ltd.

Name, Address, and Phone Number: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, TAIWAN

MERCK LTD.

20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, Taiwan

Merck KGaA

64271 Darmstadt Germany

Phone: +49 6151 72-0

Fax: +886 2-2162-1111

Fax: +886 2-8751-6262

1.5 Emergency Contact Number

Emergency Phone Number: CHEMTREC: 00801 49 1821

CHEMTREC Taipei: +886 2 7741 4207

Section 2: Hazard Identification

Chemical Hazard Classification

According to CNS 15030: Chemical Classification and Labeling (GHS 2011), not classified as a hazardous substance or mixture.

Labeling Content

No hazard pictograms, signal words, hazard statements, or precautionary statements are required.

Other Hazards

No reports available.

Section 3: Composition/Information on Ingredients

Substance/Mixture:

Substance

Ingredients:

No hazardous ingredients.

Section 4: First-Aid Measures

First-Aid Measures for Different Exposure Routes

Inhalation: After inhalation: Move the injured person to fresh air.

Skin Contact: Under skin contact: Immediately remove all contaminated clothing. Rinse skin with water/shower.

Eye Contact: After eye contact: Rinse with plenty of water. Remove contact lenses.

Ingestion: After ingestion: Immediately let the injured person drink water (up to 2 cups). Seek medical attention if feeling unwell.

Most Important Symptoms and Effects

For most important symptoms and effects, refer to the label and Section 11.

Protection for First-Aid Providers

For personal protection, see Section 8.

Information for the Physician

No data available.

Section 5: Fire-Fighting Measures

Suitable Extinguishing Media

Water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide.

Special Hazards Arising from the Substance or Mixture

Combustible material.

Vapor is heavier than air and can spread along the ground, potentially causing flashback.

Can form explosive mixtures with air upon rapid heating.

Hazardous combustible gases or vapors may be generated upon ignition.

Hazardous Combustion Products

Carbon oxides

Special Fire Fighting Procedures

Prevent fire-fighting water from contaminating surface water and groundwater systems.

Special Protective Equipment for Firefighters

Wear self-contained breathing apparatus during a fire.

Section 6: Accidental Release Measures

Personal Precautions, Protective Equipment, and Emergency Procedures

Advice for non-emergency personnel: Do not inhale vapor or aerosol. Evacuate the danger area, follow emergency procedures, and consult with professionals.

Advice for emergency responders: For personal protection, see Section 8.

Environmental Precautions

Do not allow the product to enter drains.

Methods and Materials for Containment and Cleaning Up

Cover drains. Collect, absorb, and pump out leaked material.

Comply with any applicable substance use restrictions (see Sections 7 and 10).

Absorb with liquid absorbent material (e.g., Merck's Chemizorb® adsorbent) and dispose of according to chemical waste disposal regulations, cleaning the affected area.

Section 7: Handling and Storage

Precautions for Safe Handling

Precautions: See Section 2.2.

Storage: Keep container tightly closed.

Storage Grade: 10, Flammable liquid

Recommended Storage Temperature: Refer to product label for storage temperature.

Further Information on Storage Stability: Refer to product label for storage temperature.

Section 8: Exposure Controls/Personal Protection

Control Parameters of Workplace

No substances with occupational exposure limits are present.

Biological Indicators

No biological indicators are present.

Engineering Controls

No data available.

Personal Protective Equipment

Respiratory Protection: Required when vapors/aerosols are generated. Recommendations for filtered respiratory protective devices comply with the following standards: DIN EN 143, DIN 14387, and other standards related to the respiratory protective equipment used.

Recommended Filter Type: A-(P2) type filter protective device.

Company administrators must maintain, clean, and test respiratory protective equipment according to the manufacturer's instructions and keep proper records of these measures.

Hand Protection

Material: Nitrile rubber

Solvent Permeation Time: 480 minutes

Glove Thickness: 0.11 mm

Protection Index: Full contact

Manufacturer: KCL 741 Dermatril® L

Hand Protection

Material: Nitrile rubber

Solvent Permeation Time: 480 minutes

Glove Thickness: 0.11 mm

Protection Index: Splash contact

Manufacturer: KCL 741 Dermatril® L

Remarks

This information is only applicable to Merck products and the restrictions specified in the safety data sheet. When mixing with other substances, dissolving, or in situations not covered by EN 16523-1, please contact the CE-certified glove supplier (e.g., German glove supplier KCL GmbH, website: www.kcl.de).

Eye Protection

Please use equipment that has been tested and approved according to official standards such as NIOSH (USA) or EN 166 (EU) to protect your eyes. Safety glasses.

Hygiene Measures

Change contaminated clothing. Wash hands after using this substance.

Section 9: Physical and Chemical Properties

Appearance

Form: Liquid

Color

Color: Colorless

Odor

Odor: No data available.

Odor Threshold

Odor Threshold: No data available.

pH Value

pH Value: No data available.

Melting Point/Freezing Point

Melting Point/Freezing Point: Approximately < -20 °C (Approximately 1.0132 hPa)

Decomposition: No

GLP Laboratory: Yes

Boiling Point

Boiling Point: 184 °C (1,003.2 hPa)

Method: EU Regulation (EC) No 440/2008, Annex A.2

GLP Laboratory: Yes

Flash Point (Test Method)

Flash Point: 104 °C (1,000.1 hPa)

Method: EU Regulation (EC) No 440/2008, Annex A.9, Closed Cup

GLP Laboratory: Yes

Evaporation Rate

No data available.

Flammability (solid, gas)

No data available.

Flammability (liquid)

No data available.

Vapor Pressure

No data available.

Auto-ignition Temperature

Auto-ignition Temperature: > 400 °C

> 1,000.1 - < 1,014.4 hPa

GLP Laboratory: Yes

Explosion Limits

Explosion Limits: 12.5 V%

Explosion Limits: 2.6 V%

Vapor Pressure

Vapor Pressure: 0.2 hPa (25 °C)

Method: EU Regulation (EC) No 440/2008, Annex A.4

GLP Laboratory: Yes

Vapor Density

No data available.

Relative Density

Relative Density: 1.03 (20 °C)

Method: EU Regulation (EC) No 440/2008, Annex A.3

GLP Laboratory: Yes

Density

Density: 1.036 g/cm³ (25 °C)

Solubility

Water Solubility: Completely miscible (20 °C)

Method: EU Regulation (EC) No 440/2008, Annex A.6

GLP Laboratory: Yes

Partition Coefficient: n-octanol/water

Partition Coefficient: n-octanol/water: Pow: 0.085 (20.5 °C)

log Pow: -1.07 (20.5 °C)

Method: EU Regulation (EC) No 440/2008, Annex A.8

GLP Laboratory: Yes

Estimated no bioaccumulation potential.

Decomposition Temperature

Decomposition Temperature: > 400 °C (> 1,000.1 - < 1,014.4 hPa)

Method: EU Regulation (EC) No 440/2008, Annex A.15

GLP Laboratory: Yes

Decomposition Temperature

No data available.

Viscosity

Dynamic Viscosity: 12.78 mPa.s (45 °C)

Kinematic Viscosity: No data available.

Flow Time: No data available.

Explosive Properties

No data available.

Oxidizing Properties

None

Surface Tension

Surface Tension: 71.6 mN/m, 1.01 g/L, 21.5 °C, Surface Tension, GLP Laboratory: Yes

Molecular Weight

Molecular Weight: 76.09 g/mol

Particle Characteristics

No data available.

Section 10: Stability and Reactivity

Reactivity

Can form explosive mixtures with air upon rapid heating.

Evaluated as critical value at approximately 15K (absolute temperature) below the flash point.

Chemical Stability

The chemical properties of this product are stable under standard atmospheric conditions (room temperature).

Possibility of Hazardous Reactions

Hazardous reactions under special circumstances: Increased reactivity with the following substances: Oxidizing agents, Acid anhydrides, Chlorine, Various plastics. May react violently with: Strong oxidizing agents.

Conditions to Avoid

Strong heating.

Incompatible Materials

No data available.

Hazardous Decomposition Products

Upon ignition: See Section 5 Fire-Fighting Measures.

Section 11: Toxicological Information

11.1 Information on Toxicological Effects

Acute Toxicity

LD50 Oral - Rat - Male and Female - 22,000 mg/kg

Remarks: (ECHA)

Inhalation: No data available.

LD50 Dermal - Rabbit - > 2,000 mg/kg

Remarks: (ECHA)

Corrosion/Irritation to Skin

Skin - Rabbit

Result: No skin irritation - 4h

(OECD Test Guideline 404)

Serious Eye Damage/Eye Irritation

Eyes - Rabbit

Result: No eye irritation

(OECD Test Guideline 405)

Respiratory or Skin Sensitization

Maximization Test - Guinea Pig

Result: Negative

(OECD Test Guideline 406)

Germ Cell Mutagenicity

Test Type: In vitro Chromosomal Aberration Test

Test System: Human Lymphocytes

Metabolic Activation: With or without metabolic activation

Method: OECD Test Guideline 473

Result: Negative

Test Type: Bacterial Reverse Mutation Test (AMES)

Test System: Salmonella Typhimurium

Metabolic Activation: With or without metabolic activation

Result: Negative

Remarks: (ECHA)

Test Type: Micronucleus Test

Species: Mouse

Cell Type: Bone Marrow

Exposure Route: Intraperitoneal

Result: Negative

Remarks: (ECHA)

Test Type: In vitro Chromosomal Aberration Test

Species: Rat

Cell Type: Bone Marrow

Exposure Route: Ingestion

Result: Negative

Remarks: (ECHA)

Carcinogenicity

No data available.

Reproductive Toxicity

No data available.

Specific Target Organ Toxicity - Single Exposure

No data available.

Specific Target Organ Toxicity - Repeated Exposure

No data available.

Aspiration Hazard

No data available.

11.2 Additional Information

Repeated Dose Toxicity - Rat - Male - Ingestion - 2 Years - No Observed Adverse Effect Level - 1,700 mg/kg

Remarks: (ECHA)

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Its hazards cannot be completely ruled out, but it is unlikely to cause harm when used correctly.

Operate according to industrial hygiene and safety practices.

Section 12: Ecological Information

Ecotoxicity

No data available.

Persistence and Degradability

No data available.

Bioaccumulative Potential

No data available.

Mobility in Soil

No data available.

Other Adverse Effects

No data available.

Section 13: Disposal Considerations

Waste Treatment Methods

Disposal Methods: Disposal of waste must comply with national and local regulations. Keep waste chemicals in their original containers and do not mix them with other waste. Dispose of contaminated containers in the same manner as the product.

This product must be disposed of in accordance with waste disposal regulations. Disposal of waste must comply with national and local regulations. Store chemicals in their original containers and do not mix them with other waste. Dispose of contaminated containers in the same manner as the product.

Section 14: Transport Information

International Regulations

Air Transport (IATA-DGR)

UN/ID Number: Not applicable

Proper Shipping Name: Not applicable

Transport Hazard Class(es): Not applicable

Subsidiary Risk: Not applicable

Packing Group: Not applicable

Label: Not applicable

Packing Instructions (Cargo Aircraft): Not applicable

Packing Instructions (Passenger Aircraft): Not applicable

Sea Transport (IMDG-Code)

UN Number: Not applicable

Proper Shipping Name: Not applicable

Transport Hazard Class(es): Not applicable

Subsidiary Risk: Not applicable

Packing Group: Not applicable

Label: Not applicable

EmS Number: Not applicable

Marine Pollutant (Yes/No): No

According to MARPOL 73/78 Annex II and IBC Code, not applicable to the supplied product.

Special Transport Precautions and Notes

Remarks: According to transport regulations, not classified as dangerous goods.

Section 15: Regulatory Information

Applicable Regulations

Occupational Safety and Health Act: Applicable

Occupational Safety and Health Facility Rules: Applicable

Waste Disposal Act:

Standards for Storage, Collection, and Disposal of Industrial Waste and Facility Standards: Not a dangerous or hazardous substance.

Hazardous Chemicals Labeling and Communication Rules: Not applicable

Hazardous Chemicals Assessment and Classification Management: No substances with occupational exposure limits are present.

Road Traffic Safety Act: Not applicable

Permissible Exposure Limits for Occupational Workplaces: Not applicable

Prevention of Organic Solvent Poisoning Rules: Not applicable

Prevention of Specific Chemical Substance Hazards Standards: Not applicable

Standards for the Installation, Storage, and Handling of Public Hazardous Materials and Flammable High-Pressure Gases and Safety Management: Quantity controlled

Management of Toxicity and Concerned Chemicals Act: Not applicable

Toxic Chemicals: Not applicable

Concerned Chemicals: Not applicable

Designation and Operation Management of Priority Management Chemicals: Not applicable

Section 16: Other Information

Further Information

References: For information on references, please refer to each chapter.

The information in this document is based on our current knowledge and provides appropriate safety precautions.

Additional Information

The information provided herein is believed to be accurate but does not purport to be all-inclusive and shall be used only as a guide. The information in this document is based on our current knowledge and is applicable to the product in the context of appropriate safety precautions. Sigma-Aldrich Corporation and its affiliates shall not be held liable for any damage resulting from handling or contact with the above product. For additional terms of use, please refer to the invoice or the packaging slip. For more sales terms and conditions, please see www.sigma-aldrich.com and/or the back of the invoice or packing slip.

Copyright: 2020 Sigma-Aldrich Co. LLC. Company. Permission for unlimited paper copying is granted for internal use only.

Date Format: Year/Month/Day

Full Text of Other Abbreviations

AIIC - Australian Inventory of Industrial Chemicals; ANTT - Brazilian National Land Transport Agency; ASTM - American Society for Testing and Materials; bw - body weight; CMR - Carcinogenic, Mutagenic or Reprotoxic substance; DIN - German Institute for Standardization; DSL - Domestic Substances List of Canada; ECx - Concentration of effect x%; ELx - Load of effect x%; EmS - Emergency Schedule; ENCS - Japanese Existing and New Chemical Substances List; ErCx - Concentration of growth effect x%; ERG - Emergency Response Guidebook; GHS - Globally Harmonized System of Classification and Labelling of Chemicals; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Bulk Chemical Code; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law of Japan; ISO - International Organization for Standardization; KECI - Korean Existing Chemicals Inventory; LC50 - Lethal Concentration 50%; LD50 - Lethal Dose 50%; MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - not otherwise specified; Nch - Chilean certification; NO(A)EC - No Observed Adverse Effect Concentration; NO(A)EL - No Observed Adverse Effect Level; NOELR - No Observed Effect Loading Rate; NOM - Mexican Official Standard; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Prevention, Pesticides and Toxic Substances; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippine Inventory of Chemicals and Chemical Substances; (Q)SAR - Quantitative Structure-Activity Relationship; REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals (EC) No 1907/2006 of the European Parliament and of the Council; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TDG - Transport of Dangerous Goods; TECI - Thai Inventory of Chemical Substances; TSCA - Toxic Substances Control Act of the United States; UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - very Persistent and very Bioaccumulative substance; WHMIS - Workplace Hazardous Materials Information System.

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