Millipore EMPROVE® ESSENTIAL Ph Eur, BP, FCC, ChP, JP, NF, E 524 - Safety Data Sheet

1. Product and Company Identification

1.1 Product Identification

Product Name: Sodium hydroxide pellets EMPROVE® ESSENTIAL Ph Eur, BP, FCC, ChP, JP, NF, E 524

CAS No.: 1310-73-2

Brand: Millipore

1.2 Supplier Details

Supplier Name: Sigma-Aldrich (Shanghai) Trading Co. Ltd.

Address: 509 Renqing Road, Zhangjiang High Tech East Park, Pudong, SHANGHAI, 201201, CHINA

Emergency Contact: +86 532 83889090 (NRCC) 400 120 4937 (CHEMTREC)

1.3 Recommended Use and Restrictions

Recommended Use: Pharmaceutical production and analysis.

2. Hazard Identification

2.1 Emergency Overview

Appearance: Solid

Color: White

Odor: Odorless

Hazards: May corrode metals. Causes severe skin burns and eye damage. Harmful to aquatic life.

2.2 GHS Hazard Classification

• Corrosive to metals: Category 1
• Skin corrosion/irritation: Category 1A
• Serious eye damage/eye irritation: Category 1
• Acute (short-term) aquatic hazard: Category 3

2.3 GHS Label Elements

Pictograms: ☠️ (Corrosion symbol)

Signal Word: Danger

Hazard Statements:

• H290: May be corrosive to metals.
• H314: Causes severe skin burns and eye damage.
• H402: Harmful to aquatic life.

Precautionary Statements:

• Prevention: P234: Keep only in original container. P260: Do not breathe dust. P264: Wash skin thoroughly after handling. P273: Avoid release to the environment. P280: Wear protective gloves/protective clothing/eye protection/face protection.
• Response: P301 + P330 + P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin/shower. P304 + P340 + P310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P363: Wash contaminated clothing before reuse. P390: Absorb spillage to prevent material damage.
• Storage: P405: Store locked up. P406: Store in a corrosion-resistant container with a resistant liner.
• Disposal: P501: Dispose of contents/container to an approved waste disposal plant.

3. Composition/Information on Ingredients

3.1 Substance/Mixture

Substance

3.2 Components

4. First-Aid Measures

4.1 General Advice

Emergency responders should wear self-protection. Show this safety data sheet to the doctor in attendance.

4.2 Inhalation

Move victim to fresh air. Call a physician immediately.

4.3 Skin Contact

Take off contaminated clothing immediately. Wash off with plenty of water and soap. Call a physician.

4.4 Eye Contact

Rinse with plenty of water for several minutes. Contact an ophthalmologist.

4.5 Ingestion

Rinse mouth. Let victim drink 1-2 glasses of water. Do not induce vomiting. Call a physician immediately. Do not attempt to neutralize.

4.6 Most Important Symptoms and Effects

The most important symptoms and effects are described in the labelling (see section 2.2) and/or section 11.

4.7 Advice to Physician

No data available.

5. Fire-Fighting Measures

5.1 Suitable Extinguishing Media

Water spray, Foam

5.2 Unsuitable Extinguishing Media

Water jet

5.3 Special Hazards Arising from the Substance or Mixture

Non-combustible. Hazardous decomposition products may be released in case of fire.

5.4 Protective Equipment for Firefighters

Wear self-contained breathing apparatus and protective clothing.

6. Accidental Release Measures

6.1 Personal Precautions, Protective Equipment, and Emergency Procedures

For non-emergency personnel: Avoid dust inhalation. Avoid contact with skin and eyes. Ensure adequate ventilation.

For emergency responders: Evacuate danger area, follow emergency procedures, consult expert advice.

6.2 Environmental Precautions

Do not let product enter drains.

6.3 Methods and Materials for Containment and Cleaning Up

Cover drains. Collect, dike, and pump spills. Observe possible material restrictions (see sections 7 and 10). Dry out. Dispose of. Clean affected area. Avoid dust formation.

7. Handling and Storage

7.1 Precautions for Safe Handling

See section 2.2 for precautionary measures.

7.2 Conditions for Safe Storage, Including Any Incompatibilities

Storage Conditions: Keep tightly closed. Store in a dry place.

Incompatible Containers: Do not store in aluminum, tin, or zinc containers. Do not store in metal containers.

Storage Class: 8B, Non-flammable, corrosive hazardous substance.

Recommended Storage Temperature: See product label.

Storage Stability: See product label for recommended storage temperature.

8. Exposure Controls/Personal Protection

8.1 Control Parameters

8.2 Engineering Controls

No data available.

8.3 Personal Protective Equipment

• Respiratory Protection: Required when dust is generated. Recommended filter type: P2.
• Eye/Face Protection: Wear safety glasses with side-shields or goggles conforming to recognized standards like NIOSH (US) or EN 166 (EU).
• Skin and Body Protection: Wear protective clothing.
• Hand Protection:
  • Material: Nitrile rubber
  • Permeation Time: 480 minutes
  • Glove Thickness: 0.11 mm
  • Protection Index: Full contact
  • Manufacturer: KCL 741 Dermatril® L
• Hand Protection (Splash Protection):
  • Material: Nitrile rubber
  • Permeation Time: 480 minutes
  • Glove Thickness: 0.11 mm
  • Protection Index: Splash protection
  • Manufacturer: KCL 741 Dermatril® L

Note: This recommendation applies only to the product provided by us and intended for use as specified. When dissolving or mixing with other substances, or in cases of deviation from the specified use, please contact the CE-approved hand protection manufacturer (e.g., KCL GmbH, Germany, www.kcl.de).

8.4 Hygiene Measures

Immediately change contaminated clothing. Use skin protection lotion. Wash hands and face after using this substance.

9. Physical and Chemical Properties

• Appearance: Solid
• Color: White
• Odor: Odorless
• Odor Threshold: Not applicable
• pH Value: > 14 (20 °C) (concentration or concentration range: 100 g/l)
• Melting Point: 318 °C
• Boiling Point: 1,390 °C (1,013 hPa)
• Flash Point: Not applicable
• Evaporation Rate: No data available
• Flammability (solid, gas): Product is not flammable.
• Flammability (liquid): No data available
• Burning Rate: No data available
• Upper/Lower Explosion Limit: Not applicable
• Vapor Pressure: No data available
• Vapor Density: 1.38 (Air = 1.0)
• Relative Density: No data available
• Density: 2.13 g/cm3 (20 °C)
• Solubility:
• Water Solubility: 1,090 g/l (20 °C)
• n-Octanol/Water Partition Coefficient: Not applicable for inorganic substances.
• Auto-ignition Temperature: Not applicable
• Decomposition Temperature: No data available
• Dynamic Viscosity: No data available
• Kinematic Viscosity: No data available
• Flow Time: No data available
• Explosive Properties: Not explosive.
• Oxidizing Properties: None
• Molecular Weight: 40 g/mol
• Metal Corrosion Rate: May corrode metals.
• Particle Characteristics:
• Particle Size: No data available

10. Stability and Reactivity

10.1 Reactivity

No data available.

10.2 Chemical Stability

The product is chemically stable under standard conditions (room temperature).

10.3 Possibility of Hazardous Reactions

May react violently with: Acetone, Chlorine, Ethylene oxide, Fluorine, Hydrogen halides, Hydrazine hydrate, Hydroxylamine, Anhydrides, Acrolein, Alkenes, Amines, Anhydrides, Sulfuric acid, Chloroform, Water, Hydrogen peroxide, Peroxides, Phosphides, Halogen-halogen compounds, Trichloroethylene. May decompose violently upon contact with: Organic materials, Hydrogen sulfide. May ignite or produce flammable gases or vapors upon contact with: Aluminum powder, Ammonium salts, Persulfates, Sodium borohydride, Phosphorus, Phosphorus oxides, Halogenated hydrocarbons, Light metals, Metals. Explosive/exothermic reactions possible with: Bromine, Calcium.

10.4 Conditions to Avoid

No data available.

10.5 Incompatible Materials

No data available.

10.6 Hazardous Decomposition Products

In case of fire: see section 5 Fire-fighting measures.

11. Toxicological Information

11.1 Information on Toxicological Effects

• Acute Toxicity:
  • Symptoms: Swallowing causes severe burns of mouth and throat, and danger of perforation of esophagus and stomach. Mucosal burns, cough, shortness of breath, possible damage to the respiratory tract.
  • Dermal: No data available.
• Skin Corrosion/Irritation: Skin - Rabbit: Causes burns. (Regulation (EC) No 1272/2008 Annex VI).
• Serious Eye Damage/Eye Irritation: Eyes - Rabbit: Causes serious eye damage. (OECD Test Guideline 405). (Regulation (EC) No 1272/2008 Annex VI). Causes serious eye damage.
• Respiratory or Skin Sensitization: Skin sensitization - Tested in vitro skin sensitization studies. Result: Negative. (ECHA).
• Germ Cell Mutagenicity: No data available.
• Carcinogenicity: No data available.
• Reproductive Toxicity: No data available.
• STOT-Single Exposure: No data available.
• STOT-Repeated Exposure: No data available.
• Aspiration Hazard: No data available.

11.2 Additional Information

Other hazards cannot be excluded. Handle in accordance with good industrial hygiene and safety practice.

12. Ecological Information

12.1 Ecotoxicity

• Sodium hydroxide:
• Toxicity to Fish: LC50 (Mosquitofish): 125 mg/l, Exposure time: 96 h (ECOTOX database).
• Toxicity to Aquatic Invertebrates: EC50 (Ceriodaphnia): 40.4 mg/l, Endpoint: Immobilization, Exposure time: 48 h (ECHA).
• Toxicity to Microorganisms: EC50 (Photobacterium phosphoreum): 22 mg/l, Exposure time: 15 minutes (External MSDS).

12.2 Persistence and Degradability

• Sodium hydroxide:
• Biodegradability: Note: The method for determining biodegradability is not applicable to inorganic compounds.

12.3 Bioaccumulative Potential

• Sodium hydroxide:
• n-Octanol/Water Partition Coefficient: Note: Not applicable for inorganic substances.

12.4 Mobility in Soil

No data available.

12.5 Other Adverse Effects

• Sodium hydroxide:
• PBT and vPvB assessment: PBT/vPvB: Not applicable for inorganic substances.
• Other ecological information: pH variations can cause harmful effects. Even low concentrations can form corrosive mixtures with water. Neutralization may occur in wastewater treatment plants. Avoid discharge into the environment.

13. Disposal Considerations

13.1 Disposal Methods

Dispose of remaining and non-recoverable solutions to a licensed company.

14. Transport Information

14.1 International Regulations

• Air Transport (IATA-DGR):
  • UN/ID Number: UN 1823
  • UN Proper Shipping Name: Sodium hydroxide, solid
  • Class: 8
  • Packing Group: II
  • Label: Class 8 - Corrosive substances
  • Instructions for Cargo Aircraft: 863
  • Instructions for Passenger Aircraft: 859
• Sea Transport (IMDG-Code):
  • UN Number: UN 1823
  • UN Proper Shipping Name: SODIUM HYDROXIDE, SOLID
  • Class: 8
  • Packing Group: II
  • Label: 8
  • EmS Number: F-A, S-B
  • Marine Pollutant (Yes/No): No

14.2 National Regulations

• JT/T 617:
  • UN Number: UN 1823
  • UN Proper Shipping Name: Sodium hydroxide, solid
  • Class: 8
  • Packing Group: II
  • Label: 8
  • Environmentally Hazardous: No

Special Precautions for Transport: The transport classification provided is a reference only, based on the nature of the un-packaged material described in this safety data sheet. Transport classification may vary depending on transport method, package size, and regional or national regulations.

15. Regulatory Information

15.1 Applicable Regulations

Occupational Disease Prevention Law

Regulations on the Safety Management of Hazardous Chemicals

• Catalog of Hazardous Chemicals: Listed
• Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218): Not listed
• List of Key Regulated Hazardous Chemicals: Not listed
• List of Specially Controlled Hazardous Chemicals: Not listed
• List of Explosive Precursor Chemicals: Not listed

Regulations on the Administration of Toxic Chemicals in Places of Employment

• Catalog of Highly Toxic Chemicals: Not listed

Regulations on the Administration of Precursor Chemicals

• Catalog of Precursor Chemicals and Their Categories: Not listed

Regulations on the Administration of Monitored Chemicals

• List of Monitored Chemicals: Not listed

Regulations on the Administration of Ozone Depleting Substances

• List of Controlled Ozone Depleting Substances: Not listed
• List of Import/Export Controlled Ozone Depleting Substances: Not listed

Environmental Protection Law

• List of Priority Control Chemicals: Not listed
• List of Key New Pollutants: Not listed

16. Other Information

16.1 Revision Date

2025/07/22

16.2 Other Information

The information provided is believed to be correct, but does not purport to be all-inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to the safety precautions to be taken. It does not constitute any warranty of the properties of the product. Sigma-Aldrich Company and its affiliates shall not be held liable for any damage resulting from the handling or use of the product. For further terms of use, see invoice or packaging slip. For further sales terms and conditions, see www.sigma-aldrich.com and/or the back of the invoice or packing slip. Copyright: 2020 Sigma-Aldrich Co. LLC. All rights reserved.

Abbreviations and Acronyms

ACGIH: Threshold Limit Values (TLV) of ACGIH

GBZ 2.1-2007: Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents

ACGIH / C: Ceiling

GBZ 2.1-2007 / MAC: Maximum allowable concentration

AIIC: Australian Inventory of Industrial Chemicals; ANTT: Brazilian National Land Transport Agency; ASTM: American Society for Testing and Materials; bw: body weight; CMR: Carcinogenic, Mutagenic or toxic to Reproduction; DIN: German Institute for Standardization; DSL: Canada Domestic Substances List; ECx: Concentration of efficacy; ELx: Dose of efficacy; EmS: Emergency Schedule; ENCS: Japan Existing and New Chemical Substances; ErCx: Concentration of growth rate; ERG: Emergency Response Guidebook; GHS: Globally Harmonized System of Classification and Labelling of Chemicals; GLP: Good Laboratory Practice; IARC: International Agency for Research on Cancer; IATA: International Air Transport Association; IBC: International Bulk Chemical Code; IC50: Half maximal inhibitory concentration; ICAO: International Civil Aviation Organization; IECSC: China Inventory of Existing Chemical Substances; IMDG: International Maritime Dangerous Goods; IMO: International Maritime Organization; ISHL: Japan Industrial Safety and Health Act; ISO: International Organization for Standardization; KECI: Korea Existing Chemicals Inventory; LC50: Lethal concentration, 50 percent; LD50: Lethal dose, 50 percent; MARPOL: International Convention for the Prevention of Pollution from Ships; Mercosur: Common Market of the South - Facilitation Agreement for the Transport of Dangerous Goods; n.o.s.: not otherwise specified; Nch: Chilean Certification; NO(A)EC: No observed adverse effect concentration; NO(A)EL: No observed adverse effect level; NOELR: No observed effect level rate; NOM: Mexican Official Standard; NTP: National Toxicology Program; NZIoC: New Zealand Inventory of Chemicals; OECD: Organisation for Economic Co-operation and Development; OPPTS: Office of Pollution Prevention and Toxics; PBT: Persistent, Bioaccumulative and Toxic; PICCS: Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR: (Quantitative) Structure-Activity Relationship; REACH: Registration, Evaluation, Authorisation and Restriction of Chemicals (EC) No 1907/2006; SADT: Self-Accelerating Decomposition Temperature; SDS: Safety Data Sheet; TCSI: Taiwan Chemical Substance Inventory; TDG: Dangerous Goods Transport; TECI: Thailand Existing Chemical Inventory; TSCA: Toxic Substances Control Act; UN: United Nations; UNRTDG: United Nations Recommendations on the Transport of Dangerous Goods; vPvB: very Persistent and very Bioaccumulative; WHMIS: Workplace Hazardous Materials Information System.

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