Supplement Table: Reported Cases of Cardiac Cephalalgia

Author	Age/Sex	Location	Quality	Intensity	Autonomic signs	Cardiac symptoms	Trigger	Response to nitroglycerin	ECG	Stress ECG	Cardiac enzyme	Coronary lesion	Therapy
Lefkowitz, D. 1982	62/M	bregmatic	Explosive	severe	ns	chest pain, Retrosternal pain, numbness both arms	exertional	yes	chronic ante-rolateral ischemia.	ns	ns	triple-vessel coronary artery disease.	СВА
Fleetcroft, R. 1985	78/F	frontal	ns	ns	ns	chest pain, both arms	exertional	ns	ST segments in leads S2, S3 and AVF	ns	ns	NS	Medical
Blacky, R. A. 1987	40/M	bitemporal	ns	ns	ns	None	exertional	ns	Headache and inferolateral ST-segment depression	ns	ns	100% СХА, severe stenosis RCA	Medical
Takayanagi, K. 1990	67/M	occipital	ns	ns	ns	chest pressure	exertional	ns	ST-segment elevation	ns	ns	Triplevessel disease (95% LAD, 99%RCA)	death
Takayanagi, K. 1990	64/F	ns	ns	ns	ns	chest pain	exertional	yes	ST-segment elevations in leads V2 and V3, deep Q waves	ns	ns	Triplevessel disease (95% LAD, 99%RCA)	death
Bowen, J. 1993	59/M	bifrontal	ns	severe	ns	chest pressure in the left arm.	ns	yes	ST Depression in anterior leads	ns	ns	100% RCA, 95% СХА	PTCA
Ishida, A. 1996	64/M	occipital	ns	severe	nausea	both shoulders	ns	ns	abnormal Q and inverted T waves in the inferior leads	ST-segment depression	ns	Triple vessel disease (99% RCA, 75% CXA)	PTCA
Grace, A. 1997	59/M	vertex and occipital	bursting	severe	ns	none	ns	ns	T wave inversion in anterolateral leads	ns	ns	Subocclusion RCA, 70% LDA	CAB
Lance, J. W. 1998	62/M	frontal	ns	ns	ns	Chest tightness	exertional	ns	ST depression	ns	ns	100% LAD, CAB 100% RCA	CAB
Lanza, G. A. 2000	68/M	occipital	ns	ns	ns	Bilateral shoulder pain	rest	yes	ST depression peaking in V2-4	ns	elevation	90% LAD, 90% СХА, 100% RCA	CAB
Rambihar, V. S. 2001	56/F	occipital	ns	ns	ns	Shoulders and left arm	exertional	yes	ST depression I, II, aVF, and V4-V6	ST depression in leads I, II, aVF, and V 4-6	ns	40% LM, 90% СХА, 99% RCA	CAB
Amendo, M. T. 2001	78/F	bitemporal	ns	ns	vomiting	none	ns	ns	ST elevation in I, aVL	elevation	ns	severe triple vessel disease	СВА
Amendo, M. T. 2001	77/F	frontal	ns	severe	ns	none	ns	ns	nonspecific ST-T changes and abnormal precordial R wave progression	elevation	ns	ns	ns
Auer, J. 2001	47/M	occipital	ns	ns	ns	none	ns	ns	ST-segment elevation in leads I and aVL and ST-segment depression in leads II, III, and aVF.	ns	ns	100%LAD, 80% RCA	death
Famularo, Giuseppe 2002	70/M	bilateral frontoparietal	ns	severe	sweating	none	ns	ns	ST elevation and T wave inversion V2-V3 and aVF	ns	elevation	ns	medical
Martínez, Hector R. 2002	72/F	left hemicranial and facial headache	sharp or shooting	severe	ns	none	ns	ns	inverted T waves in leads V2/v3/v4	ST segment depression	ns	three-vessel occlusive disease	СВА
McLeod, G. R. 2002	72/F	occipital	sharp and throbbing	severe	nausea, vomiti ng,and facial pallor.	chest pain	rest.	ns	ns	ns	ns	100% right coronary artery(RCA), 30%LAD	medical
Gutiérrez-Morlote, J. 2002	59/M	vertex and occipital	dull and throbbing	ns	sonophobia, photophobia and nausea and slight diaphoresis	chest discomfort	rest.	yes	ns	ns	ns	ns	Medical
Sathirapanya, P. 2004	58/M	occipital	sharp shooting	severe, ns	none	none	exertional	NS	ST-T segment elevation along V1-3 with left axis deviation.	ST segment elevation	ns	LM 50%, LAD 30%, RCA 70%	СВА
Chen, Shih-Pin 2004	76/M	Bitemporal	short-lasting	severe	ns	Chest tightness	exertional	yes	inverted T waves in leads I and AVL	ns	ns	90% LAD, 50% RCA	medical
Korantzopoulos, Panagiotis 2005	73/F	Occipital	sharp	severe	nausea and vomiting.	none	rest	yes	ST depression V2-V5	elevation	ns	70% LAD	Medical
Cutrer, F. Michael 2006	55/M	Bilateral parietal	ns	ns	ns	none	exertional	ns	ns	ns	ns	100% RCA, 60% LAD	PTCA
Seow, Vei-Ken 2007	35/M	ns	ns	severe	nausea and vomiting.	none	ns	ns	ST elevation V1-4	ns	ns	100% LAD	PTCA
Broner, Susan 2007	72/F	occipital, frontal	sharp, throbbing	severe	nausea, vomiting and facial pallor	none	rest	ns	ST elevatio II, III and avF and depression in I, avL, V1 and V2	elevation	ns	100% RCA	Medical
Wei, J-H 2007	36/M	Vertex, occipital bilateral	Dull	severe	Cardiac arrest	ns	ns	ns	ST segment elevation V2-V6	ns	ns	90% LAD	ptca
Wei, J-H 2007	85/F	Right eyeball pain	ns	ns	ns	Chest pain	ns	yes	ns	Normal coronary arteries	ns	ns	medical
Wang, Warren W. 2008	81/F	ns	ns	severe	Diaphoresis, cardiac arrest	ns	ns	ns	ST elevation of II, III, and aVF	ns	ns	99%CXA	PTCA
Dalzell, Jonathan R. 2009	44/F	occipital	ns	severe	nausea, vomiting and sweating.	none	ns	ns	ST-elevation with prominent R waves and ST-depression in leads V2-V3	elevation	ns	100% RCA	PTCA
Sendovski, Uri 2009	61/F	forehead and radiating to the rest of the head, neck and the upper back	ns	Severe	none	none	ns	ns	ST depression at the lateral wall and a mild ST elevation at the precordial leads	ns	ns	70% LAD, 80% RCA, 95% СХА, 90% PDA	PTCA
Chatzizisis, Yiannis S. 2010	42/M	Frontal, bitemporal	ns	severe	ns	ns	ns	ns	Q Wave, mild ST elevation and inverted T wave in V2-V5	elevation	ns	100% LAD	PTCA
Yang, Youngsoon 2010	44/F	Bilateral, frontal, parietal	bursting	severe	ns	chest discomfort, epigastric pain	exertional	yes	normal	ST depression	ns	RCA vasospasm	medical
Costopoulos, C. 2011	53/M	Occipital to vertex	ns	ns	Breathlessness	exertional	yes	T-wave inversion	ns	ns	Triplevessel disease	PTCA
Asvestas, Dimitrios 2014	86/M	Occipital	ns	severe	ns	none	ns	yes	ST depression in V1-V5 and ST elevation in V7-V9	Triple-vessel disease	ns	ns	PTCA (100% СХА, LAD, RCA)
Wassef, Nancy 2014	44/M	ns	ns	severe	ns	chest discomfort	exertional	ns	Headache and lateral ST elevation	normal	ns	100% LAD	PTCA
Chowdhury, Abdul Wadud 2015	51/M	Temporal, frontal, vertex and occipital	ns	ns	sweating	chest tightness	exertional	yes	ST-T changes hori-zontal ST depression	ns	ns	70% LAD, 95% СХА	PTCA
Shankar, A. 2016	73/M	ns	dull	severe	ns	chest pain	exertional	ns	normal	ns	ns	Triple-vessel disease	CAB
Prakash, Sanjay 2016	67/M	holocephalic	ns	severe	nausea.	chest discomfort, and dyspnea.	exertional	ns	Q wave in D2, D3, and aVF leads	ns	NS	Triple-vessel disease (90% RCA, 75% LAD, 70% CXA)	CAB
Wang, Miao 2017	40/M	Bitemporal	tight	moderate	palpitations, coldsweating, and facial pallor.	chest discomfort,	exertional	yes	inverted T wave	ns	ns	100% LAD, 100% RCA, 80% СХА	PTCA
MacIsaac, Ryan 2019	86/M	Bilateral holocrainal	dull	severe	tears	chest heaviness and dyspnea.	rest	yes	ns	2 mm upsloping ST depression	ns	90% RCA, 50% LAD, 60% CXA)	medical
Lazari, Jonathan 2019	64/M	holocephalic	compressing	severe	ns	none	ns	ns	ST elevation in the inferior leads (II, III and aVF)	ns	ns	RCA	PTCA
Ruiz Ortiz, M. 2020	74/F	Vertex, bifrontal, laterocervical	compressing	Moderate	nausea, vomiting	none	Exertional AND rest	ns	ST lateral and inferior	ns	ns	Triple-vessel disease	PTCA
Sun, Li 2021	83/F	ns	ns	severe	ns	none	ns	ns	ST elevation in the leads II, III, aVF, and V7-V9	ns	elevation	RCA	PTCA
Kobata, Hitoshi 2022	69/M	occipitalgia	pulsatile	severe	nausea, cold sweating,unc onsciousness	none	rest	ns	ST elevation in leads II and III.	ns	ns	100%RCA	PTCA
Kobata, Hitoshi 2022	66/F	occipitalgia	ns	Severe	Cold sweating	Chest discomfort	ns	ns	ST segment elevation in leads V3-V5.	elevation	ns	LAD 99%	PTCA
Kobata, Hitoshi 2022	54/M	occipitalgia	strangulating	ns	faintness, cold sweating,and nausea	Chest discomfort	ns	ns	ST segment elevation in leads II/III	elevation	ns	RCA 100%, LAD 90%, LCX 100%	PTCA
Kobata, Hitoshi 2022	72/M	ns	ns	severe	vomiting	none	ns	ns	ST segment depression in leads I-III,aVF, and V2-V5 and ST elevation in aVR	PCI	ns	RCA 99%, LCX 99%, LAD 75%	(RCA), IABP, ECMO

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Supplement Table: Reported Cases of Cardiac Cephalalgia

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