Honeywell Safety Data Sheet

SECTION 1. IDENTIFICATION

Product name: Oxidation-A

Number: 000000011426

Product Use Description: Laboratory chemicals, Oxidation Reagent for DNA/RNA Synthesis

Manufacturer or supplier's details: Honeywell International Inc., 1953 South Harvey Street, Muskegon, MI 49442

For more information call: 1-800-368-0050, +1-231-726-3171 (Monday-Friday, 9:00am-5:00pm)

In case of emergency call: Medical: 1-800-498-5701 or +1-303-389-1414; Transportation (CHEMTREC): 1-800-424-9300 or +1-703-527-3887 (24 hours/day, 7 days/week)

SECTION 2. HAZARDS IDENTIFICATION

Emergency Overview:

Form: liquid, clear

Color: red

Odor: ether-like

Classification of the substance or mixture: Flammable liquids, Category 2; Acute toxicity, Category 4, Oral; Eye irritation, Category 2A; Carcinogenicity, Category 2; Specific target organ toxicity - single exposure, Category 3, Respiratory system

GHS Label elements, including precautionary statements:

Symbol(s):

Signal word: Danger

Hazard statements: Highly flammable liquid and vapour. Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing cancer.

Precautionary statements:

Prevention: Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ ventilating/ lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/ fume/ gas/mist/ vapours/ spray. Wash skin thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/ eye protection/ face protection.

Response: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/ attention. Rinse mouth. If eye irritation persists: Get medical advice/ attention. In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.

Storage: Store in a well-ventilated place. Keep container tightly closed. Keep cool. Store locked up.

Disposal: Dispose of contents/ container to an approved waste disposal plant.

Carcinogenicity:

ACGIH: Tetrahydrofuran - A3: Confirmed animal carcinogen (109-99-9); Pyridine - A3: Confirmed animal carcinogen (110-86-1)

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical nature: Mixture

SECTION 4. FIRST AID MEASURES

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Use oxygen as required, provided a qualified operator is present. Call a physician.

Skin contact: Wash off immediately with plenty of water for at least 15 minutes. Take off contaminated clothing and shoes immediately. Wash contaminated clothing before re-use. Call a physician.

Eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Call a physician.

Ingestion: Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Call a physician.

Notes to physician: Treat symptomatically.

SECTION 5. FIREFIGHTING MEASURES

Suitable extinguishing media: Carbon dioxide (CO2), Dry chemical, Alcohol-resistant foam. Cool closed containers exposed to fire with water spray.

Unsuitable extinguishing media: Do not use a solid water stream as it may scatter and spread fire.

Specific hazards during firefighting: Extremely flammable. Vapours may form explosive mixtures with air. Vapours are heavier than air and may spread along floors. Vapors may travel to areas away from work site before igniting/flashing back to vapor source. In case of fire hazardous decomposition products may be produced such as: Hydrogen cyanide (hydrocyanic acid), Ammonia, Carbon dioxide (CO2), carbon monoxide (CO), oxides of nitrogen (NOx), dense black smoke.

Special protective equipment for firefighters: Wear self-contained breathing apparatus and protective suit.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures: Wear personal protective equipment. Immediately evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Ensure adequate ventilation. Remove all sources of ignition. Do not swallow. Avoid breathing vapours, mist or gas. Avoid contact with skin, eyes and clothing.

Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Discharge into the environment must be avoided. Do not flush into surface water or sanitary sewer system. Do not allow run-off from fire fighting to enter drains or water courses.

Methods and materials for containment and cleaning up: Ventilate the area. No sparking tools should be used. Use explosion-proof equipment. Contain and collect spillage with non-combustible absorbent materials, e.g. sand, earth, vermiculite, diatomaceous earth and place in container for disposal according to local regulations (see section 13).

SECTION 7. HANDLING AND STORAGE

Handling:

Precautions for safe handling: Wear personal protective equipment. Use only in well-ventilated areas. Keep container tightly closed. Do not smoke. Do not swallow. Avoid breathing vapours, mist or gas. Avoid contact with skin, eyes and clothing.

Advice on protection against fire and explosion: Keep away from fire, sparks and heated surfaces. Take precautionary measures against static discharges. Ensure all equipment is electrically grounded before beginning transfer operations. Keep product and empty container away from heat and sources of ignition. No sparking tools should be used. Use explosion-proof equipment. No smoking.

Storage: Store in area designed for storage of flammable liquids. Protect from physical damage. Keep containers tightly closed in a dry, cool and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Keep away from heat and sources of ignition. Keep away from direct sunlight. Store away from incompatible substances. Container hazardous when empty. Do not pressurize, cut, weld, braze, solder, drill, grind or expose containers to heat or sources of ignition.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures: Ensure that eyewash stations and safety showers are close to the workstation location.

Engineering measures: Use with local exhaust ventilation. Prevent vapour buildup by providing adequate ventilation during and after use.

Eye protection: Do not wear contact lenses. Wear as appropriate: Safety glasses with side-shields. If splashes are likely to occur, wear: Goggles or face shield, giving complete protection to eyes.

Hand protection: Solvent-resistant gloves. Gloves must be inspected prior to use. Replace when worn.

Skin and body protection: Wear as appropriate: Solvent-resistant apron. Flame retardant antistatic protective clothing. If splashes are likely to occur, wear: Protective suit.

Respiratory protection: In case of insufficient ventilation wear suitable respiratory equipment. For rescue and maintenance work in storage tanks use self-contained breathing apparatus. Use NIOSH approved respiratory protection.

Hygiene measures: When using, do not eat, drink or smoke. Wash hands before breaks and immediately after handling the product. Keep working clothes separately. Remove and wash contaminated clothing before re-use. Do not swallow. Avoid breathing vapours, mist or gas. Avoid contact with skin, eyes and clothing.

Exposure Guidelines:

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Physical state: liquid, clear

Color: red

Odor: ether-like

pH: Note: Not applicable

Melting point/range: -108.5 °C

Boiling point/boiling range: 66 °C

Flash point: 5 °F (-15 °C) Method: closed cup

Lower explosion limit: 2%(V)

Upper explosion limit: 11.8%(V)

Vapor pressure: 189.32 hPa

Vapor density: 2.5 Note: (Air = 1.0)

Density: 0.935 g/cm3 at 20 °C; 0.929 g/cm3 at 25 °C

Water solubility: Note: completely soluble

Ignition temperature: 321 °C

SECTION 10. STABILITY AND REACTIVITY

Chemical stability: Stable under recommended storage conditions.

Possibility of hazardous reactions: Reacts with air to form peroxides. Hazardous polymerisation does not occur.

Conditions to avoid: Heat, flames and sparks. Keep away from direct sunlight. Protect from exposure to air/oxygen (peroxide formation). Protect against light.

Incompatible materials: Strong acids and strong bases. Strong oxidizing agents. May form explosive peroxides. May attack many plastics, rubbers and coatings.

Hazardous decomposition products: Peroxides. In case of fire hazardous decomposition products may be produced such as: Hydrogen iodide (HI), Ammonia, Hydrogen cyanide (hydrocyanic acid), Carbon dioxide (CO2), carbon monoxide (CO), oxides of nitrogen (NOx), dense black smoke.

SECTION 11. TOXICOLOGICAL INFORMATION

Acute oral toxicity: Acute toxicity estimate: 1,197 mg/kg Method: Calculation method

Acute inhalation toxicity:

• Tetrahydrofuran: LC50: ca. 61.9 mg/l 21000 ppm; Exposure time: 3 h; Species: Rat
• Pyridine: LC50: 5400 ppm, vapour; Exposure time: 4 h; Species: Rat, male
• Iodine: LC50: > 4.588 mg/l, dust/mist; Exposure time: 4 h; Species: Rat

Acute dermal toxicity: Acute toxicity estimate: > 5,000 mg/kg Method: Calculation method

Skin irritation:

• Tetrahydrofuran: Species: Rabbit; Result: Irritating to skin.
• Iodine: Species: reconstructed human epidermis (RhE); Result: Irritating to skin.

Eye irritation:

• Tetrahydrofuran: Species: Rabbit; Result: Irritating to eyes.
• Pyridine: Species: Rabbit; Result: Irritating to eyes.

Mutagenicity/Genotoxicity:

• Pyridine: Test Method: Ames test; Result: negative; Test Method: Chromosome aberration test in vitro; Cell type: Chinese Hamster Ovary Cells; Result: negative; Test Method: Cell Transformation Test; Result: negative

Further information:

• Tetrahydrofuran: Note: Confirmed animal carcinogen with unknown relevance to humans.
• Pyridine: Note: Confirmed animal carcinogen with unknown relevance to humans.

SECTION 12. ECOLOGICAL INFORMATION

Toxicity to fish:

• Tetrahydrofuran: LC50: 2,160 mg/l; Exposure time: 96 h; Species: Pimephales promelas (fathead minnow); LC50: 2,820 mg/l; Species: Leuciscus idus (Golden orfe)
• Pyridine: LC50: 99 mg/l; Exposure time: 96 h; Species: Pimephales promelas (fathead minnow)
• Iodine: LC50: 1.67 mg/l; Exposure time: 96 h; Species: Oncorhynchus mykiss (rainbow trout)

Toxicity to daphnia and other aquatic invertebrates:

• Pyridine: EC50: 320 mg/l; Exposure time: 48 h; Species: Daphnia magna (Water flea); Method: OECD Test Guideline 202
• Iodine: LC50: 0.55 mg/l; Exposure time: 48 h; Species: Daphnia magna (Water flea)

Toxicity to algae:

• Iodine: Growth inhibition; EC50: 0.13 mg/l; Exposure time: 72 h; Species: Desmodesmus subspicatus (green algae); Method: OECD Test Guideline 201

Toxicity to bacteria:

• Tetrahydrofuran: LC50: > 580 mg/l; Exposure time: 16 h; Species: Bacteria

Further information on ecology:

• Additional ecological information: Harmful to aquatic organisms.
• Pyridine: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
• Iodine: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

SECTION 13. DISPOSAL CONSIDERATIONS

Disposal methods: Observe all Federal, State, and Local Environmental regulations.

SECTION 14. TRANSPORT INFORMATION

DOT: UN/ID No.: UN 1993; Proper shipping name: Flammable liquids, n.o.s. (Tetrahydrofuran, Pyridine); Class: 3; Packing group: II; Hazard Labels: 3

IATA: UN/ID No.: UN 1993; Description of the goods: Flammable liquids, n.o.s. (Tetrahydrofuran, Pyridine); Class: 3; Packaging group: II; Hazard Labels: 3; Packing instruction (cargo aircraft): 364; Packing instruction (passenger aircraft): 353; Packing instruction (passenger aircraft): Y341

IMDG: UN/ID No.: UN 1993; Description of the goods: Flammable liquids, n.o.s. (TETRAHYDROFURAN, PYRIDINE); Class: 3; Packaging group: II; Hazard Labels: 3; EmS Number: F-E, S-E

Marine pollutant: no

SECTION 15. REGULATORY INFORMATION

Inventories:

• US. Toxic Substances Control Act: On TSCA Inventory
• Australia. Industrial Chemical (Notification and Assessment) Act: On the inventory, or in compliance with the inventory
• Canada. Canadian Environmental Protection Act (CEPA). Domestic Substances List (DSL): All components of this product are on the Canadian DSL
• Japan. Kashin-Hou Law List: On the inventory, or in compliance with the inventory
• Korea. Existing Chemicals Inventory (KECI): On the inventory, or in compliance with the inventory
• Philippines. The Toxic Substances and Hazardous and Nuclear Waste Control Act: On the inventory, or in compliance with the inventory
• China. Inventory of Existing Chemical Substances: On the inventory, or in compliance with the inventory
• New Zealand. Inventory of Chemicals (NZIoC), as published by ERMA New Zealand: On the inventory, or in compliance with the inventory

National regulatory information:

• US. Drug Enforcement Administration (DEA) Listed: On the United States Drug Enforcement Authority (DEA) List of Precursors and Essential Chemicals
• Precursor and Essential Chemicals (21 CFR 1310): Iodine 7553-56-2
• US. EPA CERCLA Hazardous Substances (40 CFR 302): The following component(s) of this product is/are subject to release reporting under 40 CFR 302 when release exceeds the Reportable Quantity (RQ): Reportable quantity: 1000 lbs; Tetrahydrofuran 109-99-9; Pyridine 110-86-1
• SARA 302 Components: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
• SARA 313 Components: The following components are subject to reporting levels established by SARA Title III, Section 313: Pyridine 110-86-1
• SARA 311/312 Hazards: Fire Hazard, Acute Health Hazard, Reactivity Hazard, Chronic Health Hazard
• CERCLA Reportable Quantity: 1488 lbs
• California Prop. 65: ⚠️ WARNING: This product can expose you to chemicals, listed below, known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov. Pyridine 110-86-1
• Massachusetts RTK: Tetrahydrofuran 109-99-9; Pyridine 110-86-1; Iodine 7553-56-2
• New Jersey RTK: Tetrahydrofuran 109-99-9; Pyridine 110-86-1; Iodine 7553-56-2
• Pennsylvania RTK: Tetrahydrofuran 109-99-9; Pyridine 110-86-1; Iodine 7553-56-2

SECTION 16. OTHER INFORMATION

HMIS III: Health hazard: 2*; Flammability: 3; Physical Hazard: 1; Instability: 1

NFPA: Health hazard: 2; Flammability: 3; Physical Hazard: 1; Instability: 1

* - Chronic health hazard

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the use of individuals trained in the particular system.

Further information: The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text. Final determination of suitability of any material is the sole responsibility of the user. This information should not constitute a guarantee for any specific product properties.

Changes since the last version are highlighted in the margin. This version replaces all previous versions.

Previous Issue Date: 07/30/2015

Prepared by: Honeywell Performance Materials and Technologies Product Stewardship Group