HIGH STAKES. HIGH STANDARDS.

PLACE YOUR TRUST IN THE SUREST HANDS

When health and lives are at stake, laboratories performing analyses should use top-quality testing products provided by a proven manufacturer.

Honeywell Research Chemicals understands that quality is crucial at every step of your pharmaceutical & biopharmaceutical workflows. With analytical technologies and associated costs advancing at a record pace, the need for high-quality chemicals is greater than ever before.

Per a recent Forbes article on pharmaceutical price transparency, it can take up to 12 years and $2.6 billion to bring a single new drug to market. [1] With such high stakes, we know that our standards must be high. That's why we've developed an analytical chemical portfolio delivering the highest purity reagents and solvents, and reliable analytical standards, to save time and reduce costs at every stage of your workflows.

From drug discovery and development to quality control, you're in the surest hands with Honeywell Research Chemicals. We've taken the guesswork out of choosing the right chemicals for each stage of your workflows with our comprehensive product guides and helpful resources.

PHARMACEUTICAL & BIOPHARMACEUTICAL WORKFLOW SOLUTIONS FOR:

• Oligonucleotide Synthesis
• Chromatography
• Water Determination
• Elemental Impurities

OLIGONUCLEOTIDE SYNTHESIS WORKFLOW SOLUTIONS

Critical to advancing drug discovery processes

Honeywell Burdick & Jackson™™™ BioSyn™™™ solvents and reagents have low impurity profiles and ensure higher yields.

The Burdick & Jackson™™™ BioSyn™™™ product line from Honeywell Research Chemicals offers a wide range of DNA and RNA synthesis solvents and reagents for each step of the oligonucleotide synthesis cycle. This includes reagents for deblocking, activation, capping, and oxidation in various formulations, as well as acetonitrile with extremely low water content.

Scientists using the BioSyn product line will enjoy the following benefits:

• High-purity reagents employing consistent quality manufacturing standards to ensure improved overall yield of the final product
• Filtered to minimize particulate contamination (0.2 micron for oxidation reagents and 0.1 micron for all other reagents)
• Available in package sizes from 1L glass bottles to 1.250L bulk containers suitable for lab-scale oligonucleotide synthesis through production levels
• Packaging designed to facilitate direct connection to popular synthesizers
• Custom solutions provided to meet specific customer needs (e.g., custom reagent formulations to address special packaging requirements)

In addition, Honeywell offers a variety of Riedel-de Haën™™™ branded, septum-sealed, moisture-sensitive anhydrous solvents suitable for many biotech and biopharma applications.

WORKFLOW

1. DEBLOCKING (DETRITYLATION)
2. ACTIVATION/COUPLING
3. CAPPING
4. OXIDATION

CHROMATOGRAPHY WORKFLOW SOLUTIONS

Essential for verifying product purity

Honeywell solvents, blends and standards provide low impurity and high consistency.

With Honeywell chromatography solvents, prepared and customizable solvent blends, eluent additives, and analytical standards, pharmaceutical and biopharmaceutical labs can utilize high-quality products throughout the entire chromatography workflow with the following benefits:

• High purity for cleaner chromatograms
• Low lot-to-lot variation for better consistency
• Reduced time and cost to obtain correct and reliable results the first time

Honeywell solutions are particularly advantageous for demanding applications such as LC-MS and UHPLC-MS that rely on low baseline noise to achieve the required sensitivity.

Honeywell Research Chemicals has over 200 years of expertise in high-purity solvents, produced in two ISO 9001-certified production plants in the USA and Germany. To meet the most challenging analytical requirements, customers can choose from a wide portfolio of solvents, Honeywell LabReady™™™ blends from Riedel-de Haën™ and Burdick & Jackson™, as well as eluent additives and analytical standards from Fluka™.

Honeywell Fluka analytical standards include an expanding portfolio of high-quality organic reference materials, produced according to ISO 9001 and suitable for a wide range of industries and applications. Every vial comes complete with a printed certificate of analysis (CoA) and is eligible for free expert technical support-ensuring you have the information needed to quickly start your analysis and pass relevant audits.

WORKFLOW

1. SAMPLE PREPARATION AND PURIFICATION
2. CALIBRATION
3. SEPARATION/ANALYSIS

WATER DETERMINATION WORKFLOW SOLUTIONS

Crucial for confirming water content

Hydranal™™™ reagents provide best-in-class accuracy and unparalleled technical support.

Karl Fischer titration (KFT) is the preferred technique for water determination due to its superior accuracy, increased speed and selectivity, and practical advantages over other methods.

Today, however, the lack of skilled chemists with experience using the KFT technique can undermine its effectiveness and the quality of results. This situation can have serious consequences in the biopharmaceutical field where water content impacts drug stability, crystal structure, powder flow, dissolution rate, and polymer film permeability in solid dosage forms. It can also lead to growth of microorganisms if unchecked. Errors in analysis often result in costly production stoppages and health risks.

Honeywell's Karl Fischer titration product line, Hydranal™, focuses on optimizing the water determination workflow. Hydranal reagents provide the following advantages:

• Brand name synonymous with the highest standard of accuracy and reliable lot-to-lot consistency
• Unique in offering special media for customer-specific needs (largest portfolio in KFT segment)
• Unparalleled technical support to tackle challenging samples

WORKFLOW

1. INSTRUMENT & REAGENT SETUP
2. SYSTEM CALIBRATION
3. SAMPLE PREPARATION, ANALYSIS & METHOD ADAPTATION
4. RESULT VALIDATION

ELEMENTAL IMPURITIES WORKFLOW SOLUTIONS

Vital for identifying trace contaminants

TraceSelect™™™ solvents and reagents enable increased precision and reliability.

Understanding the elemental composition of your raw materials, active pharmaceutical ingredients (APIs), excipients, and formulations helps to ensure product quality and purity. Trace metals are known to be toxic and can affect the stability of a formulation by catalyzing degradation. Quality control during the manufacturing process is also very important and should be monitored regularly. The presence of trace species at very low levels and samples with poor solubility can make elemental analysis difficult.

Honeywell's TraceSelect™™ solvents and reagents are supplied in high-quality leach-resistant bottles to ensure long-term purity.

Our certificates of analysis list up to 80 individual metal and anion traces. TraceSelect reagents and solvents and certified reference materials provide the following benefits:

• Reliable Fluka™™ certified reference materials supplied with complete documentation and traceable to NIST standard reference materials
• Meets requirement for high-purity acids and bases with low contamination levels to improve reliability and accuracy
• Enables detection of impurities in the ppt and ppb detection range

WORKFLOW

1. SAMPLE PREPARATION
2. CALIBRATION
3. ANALYSIS

OUR SERVICES

The growth of Honeywell's brands and recognized product portfolio is matched by significant expansion of our manufacturing sites, technical services, customer support, global distribution centers, and authorized distributor partners.

These new facilities, services and partnerships enable us to support customers in more ways than ever, offering a host of custom solutions, expert customer assistance, worldwide centers of excellence, advanced manufacturing capabilities, and a global supply chain and distribution partnership.

GLOBAL FOOTPRINT

Product Experts and Channel Partners Available to Meet Your Needs

We are proud to partner with more than 200 authorized distributors in 100-plus countries to meet the needs of research chemists working across applications and industries.

In addition to an extensive distribution network, we have invested in seven warehousing and fulfillment centers across Europe, the Americas and Asia to enable uninterrupted access to our products and services worldwide.

Our partners, supported by our product experts, are equipped to help customers with a wide range of technical questions. Whether it's a packaging inquiry, technical specification request, quality-related question or advice on a custom formulation, we strive to respond in a timely manner.

We provide unparalleled global support on Karl Fischer titration through the Hydranal Center of Excellence and Application Labs in Germany and China. Hydranal™ reagents conform to the highest standards in quality control and have been a leader in Karl Fischer chemistry for decades. Our team of experts conducts regular seminars, webinars and workshops in partnership with leading equipment manufacturers across the globe.

ABOUT OUR BRANDS

The genesis of Honeywell Research Chemicals began in 1814, when German chemist Johann Daniel Riedel successfully manufactured a series of pharmaceutical products, building a foundation for the chemicals industry.

The world has changed considerably since then, but our commitment to continued innovation in inorganics, solvents and other essential chemicals has not wavered.

Product lines

As part of our efforts to provide an ever-growing and innovative portfolio, we are pleased to introduce a broad offering of premium solvents and analytical reagents commonly used in chemistry and analytical workflows.