Safety Data Sheet

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product Identifiers

Product Name: 2-Ethyl-1-hexanol for Synthesis

Product Number: 8.00990

Article Number: 800990

Brand: Millipore

REACH No.: 01-2119487289-20-XXXX

CAS No.: 104-76-7

1.2 Relevant Identified Uses of the Substance or Mixture and Uses Advised Against

Identified Uses: Synthesis chemical

1.3 Details of the Supplier of the Safety Data Sheet

Company: Merck KGaA
Frankfurter Str. 250
D-64271 DARMSTADT

Phone: +49 (0)6151 72-0

Fax: +49 6151 727780

Email Address: TechnischerService@merckgroup.com

1.4 Emergency Telephone Number

Emergency Tel. No.: Works Fire Department: +49 (0)6151/722440 *
Telefax: +49 (0)6151/727780 *
Poison Information Centre Freiburg: +49(0)76119240 *
CHEMTREC Germany: 0800 181 7059

SECTION 2: Hazards Identification

2.1 Classification of the Substance or Mixture

Classification (REGULATION (EC) No 1272/2008):

• Acute Toxicity, Category 4: H332: Harmful if inhaled.
• Skin Irritation, Category 2: H315: Causes skin irritation.
• Eye Irritation, Category 2: H319: Causes serious eye irritation.
• Specific Target Organ Toxicity - Single Exposure, Category 3, Respiratory System: H335: May cause respiratory irritation.
• Hazardous to the aquatic environment (chronic), Category 3: H412: Harmful to aquatic life with long lasting effects.

2.2 Label Elements

Hazard Pictograms: ⚠️

Signal Word: Warning

Hazard Statements:

• H315: Causes skin irritation.
• H319: Causes serious eye irritation.
• H332: Harmful if inhaled.
• H335: May cause respiratory irritation.
• H412: Harmful to aquatic life with long lasting effects.

Precautionary Statements:

• Prevention:
• P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264: Wash skin thoroughly after handling.
• P273: Avoid release to the environment.
• Response:
• P302 + P352: IF ON SKIN: Wash with plenty of water.
• P304 + P340 + P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
• P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Reduced Labeling (<= 125 ml):

Pictogram: ⚠️

Signal Word: Warning

Hazard Statements: H412: Harmful to aquatic life with long lasting effects.

SECTION 3: Composition/Information on Ingredients

3.1 Substances

SECTION 4: First Aid Measures

4.1 Description of First Aid Measures

General Advice: Show this safety data sheet to the doctor.

After Inhalation: Move to fresh air.

After Skin Contact: Remove contaminated clothing immediately. Wash skin with water/shower.

After Eye Contact: Rinse with plenty of water. Seek medical attention.

After Ingestion: Rinse mouth. Do NOT induce vomiting. Drink water (maximum 2 drinking glasses). Consult a doctor.

4.2 Most Important Symptoms and Effects, Both Acute and Delayed

The most important known symptoms and effects are described in the labeling (see Section 2.2) and/or Chapter 11.

4.3 Indication of any Immediate Medical Attention and Special Treatment Needed

No data available

SECTION 5: Firefighting Measures

5.1 Extinguishing Media

Suitable Extinguishing Media: Carbon dioxide (CO2), Foam, Dry powder

Unsuitable Extinguishing Media: No restrictions on extinguishing media for this substance/mixture.

5.2 Special Hazards Arising from the Substance or Mixture

Hazards from the substance or mixture: Combustible. Vapors are heavier than air and may spread along the ground. Explosive mixtures with air may occur upon strong heating. Hazardous combustion gases or vapors may form in the event of a fire.

Hazardous Combustion Products: Carbon oxides

5.3 Advice for Firefighters

Special Protective Equipment for Firefighters: Stay in the danger area only with self-contained breathing apparatus. Avoid skin contact by maintaining a safe distance or wearing appropriate protective clothing.

Further Information: Move containers out of the danger zone, cool with water. Do not allow extinguishing water to enter surface water or groundwater systems.

SECTION 6: Accidental Release Measures

6.1 Personal Precautions, Protective Equipment and Emergency Procedures

Personal Precautions: Advice for non-trained personnel: Do not inhale vapor/aerosol. Avoid contact with substance. Ensure adequate ventilation. Keep away from heat and ignition sources. Evacuate danger zone, follow emergency plan, consult experts.

Personal protective equipment see Section 8.

6.2 Environmental Precautions

Environmental Precautions: Do not allow to enter drains.

6.3 Methods and Material for Containment and Cleaning Up

Cleaning Procedures: Seal drains. Collect, dike, and pump off. Observe possible material restrictions! (See Section 7 or Section 10). Absorb with liquid-binding material, e.g., Chemizorb®. Dispose of according to regulations. Clean up afterwards.

6.4 Reference to Other Sections

For disposal information see Section 13.

SECTION 7: Handling and Storage

7.1 Precautions for Safe Handling

Advice for safe handling: Work under a fume hood. Do not inhale substance/mixture. Avoid development of vapors/aerosols.

Advice on protection against fire and explosion: Keep away from open flames, hot surfaces and ignition sources. Take measures against electrostatic discharge.

Hygiene measures: Change contaminated clothing immediately. Preventive skin protection. Wash hands and face after work.

Information on protective measures can be found in Section 2.2.

7.2 Conditions for Safe Storage, Including Any Incompatibilities

Further information on storage conditions: Keep tightly closed.

Storage Class (TRGS 510): 10, Flammable liquids

Further information on storage stability: Recommended storage temperature see product label.

SECTION 8: Exposure Controls/Personal Protection

8.1 Control Parameters

8.2 Exposure Controls

Personal Protective Equipment:

• Eye/Face Protection: Use only equipment for eye protection that has been tested and approved according to official standards, such as NIOSH (US) or EN 166 (EU). Safety glasses.
• Hand Protection:
  Material: Nitrile rubber
  Breakthrough time: 480 min
  Glove thickness: 0.4 mm
  Protection Index: Full contact
  Manufacturer: Camatril® (KCL 730 / Aldrich Z677442, Size M)
  Material: Nitrile rubber
  Breakthrough time: 30 min
  Glove thickness: 0.11 mm
  Protection Index: Splash contact
  Manufacturer: KCL 741 Dermatril® L

Remarks: This recommendation applies only to the product named in the safety data sheet, supplied by us and for the intended use. For solutions in or mixtures with other substances and under conditions deviating from EN 16523-1, please contact the supplier of CE-approved gloves (e.g., KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Skin and Body Protection: Protective clothing

Respiratory Protection: Required if vapors/aerosols are present. Our recommendations for respiratory filters are based on the following standards: DIN EN 143, DIN 14387 and associated standards for respiratory systems.

Recommended Filter Type: Filter A

The employer must ensure that maintenance, cleaning, and testing of respiratory protective equipment are carried out according to the manufacturer's user information and are documented accordingly.

Exposure Controls and Monitoring of Environmental Exposure:

Note: Do not allow to enter drains.

SECTION 9: Physical and Chemical Properties

9.1 Information on Basic Physical and Chemical Properties

Physical State: liquid

Color: colorless

Odor: No data available

Melting Point: -89 °C (Method: ISO 3016)

Boiling Point: 186 °C (1.013 hPa) (Method: OECD Guideline 103)

Flammability: No data available

Upper Explosion Limit / Upper Explosion Limit: 9.7%(V) (113 °C)

Lower Explosion Limit / Lower Explosion Limit: 0.88 %(V) (104 °C)

Flash Point: 75 °C(1.013 hPa) (Method: closed cup)

Ignition Temperature: 280 °C (1.017 hPa) (Method: Regulation (EC) No. 440/2008, Annex, A.15 GLP: yes)

Decomposition Temperature: No data available

pH Value: No data available

Dynamic Viscosity: 9.7 mPa.s (20 °C)
4.3 mPa.s (40 °C)

Kinematic Viscosity: No data available

Evaporation Rate: No data available

Solubility(ies):

• Water Solubility: 0.9 g/l (20 °C) pH Value: 5.8 (Method: OECD Guideline 105) partially soluble

Partition Coefficient: n-Octanol/Water: log Pow: 2.9 (25 °C) pH Value: 7.0 (Method: OECD Guideline 117) Bioaccumulation is not expected.

Vapor Pressure: 0.93 hPa (20 °C) (Method: OECD Guideline 104 GLP: yes)

Relative Density: 0.83 (20 °C)

Density: 0.833 g/cm3 (20 °C) (Method: DIN 51757)

Relative Vapor Density: 4.5 (Air = 1.0)

Particle Characteristics: No data available

9.2 Other Information

Explosive Properties: Not classified as explosive.

Oxidizing Properties: none

Burning Rate: No data available

Evaporation Rate: No data available

Surface Tension: 47 mN/m, 0.81 g/l, 20 °C, OECD Guideline 115

Molecular Weight: 130.23 g/mol

SECTION 10: Stability and Reactivity

10.1 Reactivity

Explosive mixtures with air may occur upon strong heating. A range of approximately 15 Kelvin below the flash point is considered critical.

10.2 Chemical Stability

The product is chemically stable under normal ambient conditions (room temperature).

10.3 Possibility of Hazardous Reactions

Hazardous Reactions: Violent reactions possible with: Strong oxidizing agents, Strong acids and strong bases

10.4 Conditions to Avoid

Conditions to Avoid: Strong heating.

10.5 Incompatible Materials

Substances to Avoid: various plastics

10.6 Hazardous Decomposition Products

In case of fire: see Chapter 5

SECTION 11: Toxicological Information

11.1 Information on Toxicological Effects

Acute Toxicity:

• LD50 Oral - Rat - male - 2,047 mg/kg (OECD Guideline 401)
• LC50 Inhalation - Rat - male and female - 4 h - 0.89 - 5.3 mg/l - Vapor (OECD Guideline 403) Inhalation: Irritates the respiratory organs.
• LD50 Dermal - Rat - male - > 3,000 mg/kg Remarks: (RTECS)

Skin Corrosion/Irritation:

• Skin - Rabbit: Result: Skin irritation - 24 h (OECD Guideline 404)

Serious Eye Damage/Irritation:

• Eyes - Rabbit: Result: Causes serious eye irritation. (OECD Guideline 405)

Respiratory or Skin Sensitization: No data available

Germ Cell Mutagenicity:

• Test Type: Ames test Test System: Escherichia coli/Salmonella typhimurium Metabolic Activation: with and without metabolic activation Method: OECD Guideline 471 Result: negative
• Test Type: Mutagenicity (Mammalian Cell Test): Chromosome Aberration. Test System: Ovarian cells of Chinese Hamster Metabolic Activation: with and without metabolic activation Method: OECD Guideline 473 Result: negative
• Test Type: In vitro Mammalian Cell Gene Mutation Test Test System: Mouse Lymphoma Cells Metabolic Activation: with and without metabolic activation Method: OECD Guideline 476 Result: negative

Carcinogenicity: No data available

Reproductive Toxicity: No data available

Specific Target Organ Toxicity - Single Exposure: Inhalation - May cause respiratory irritation.

Specific Target Organ Toxicity - Repeated Exposure: No data available

Aspiration Hazard: No data available

11.2 Further Information

Endocrine Disrupting Properties:

• Product:
• Assessment: The substance/mixture does not contain any components that, according to REACH Article 57(f) or Commission Delegated Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, have endocrine-disrupting properties in quantities of 0.1% or more.

SECTION 12: Ecological Information

12.1 Toxicity

Substances:

• 2-Ethylhexan-1-ol:
• Toxicity to Fish: LC50 (Leuciscus idus (Golden orfe)): 17.1 mg/l Exposure time: 96 h Test Type: Flow-through test Analytical monitoring: yes Method: OECD Guideline 203 GLP: yes
• Toxicity to Daphnia and Other Aquatic Invertebrates: EC50 (Daphnia magna (Water flea)): 39 mg/l Endpoint: Immobilization Exposure time: 48 h Test Type: static test Method: Regulation (EC) No. 440/2008, Annex, C.2 GLP: yes
• Toxicity to Algae/Aquatic Plants: ErC50 (Desmodesmus subspicatus (Green algae)): 16.6 mg/l Exposure time: 72 h Test Type: static test Method: Regulation (EC) No. 440/2008, Annex, C.3 GLP: yes
• Toxicity to Microorganisms: EC10 (Pseudomonas putida): 540 mg/l Exposure time: 18 h Method: DIN 38412 Remarks: (IUCLID)
• Toxicity to Fish (Chronic Toxicity): NOEC: 0.193 mg/l Exposure time: 30 d Species: Danio rerio (Zebrafish) Analytical monitoring: yes Method: OECD Guideline 210 GLP: yes Remarks: (ECHA)
• Toxicity to Daphnia and Other Aquatic Invertebrates (Chronic Toxicity): NOEC: 1.06 mg/l Exposure time: 21 d Species: Daphnia magna (Water flea) Analytical monitoring: yes Method: OECD Guideline 211 GLP: yes Remarks: (ECHA)

12.2 Persistence and Degradability

Substances:

• 2-Ethylhexan-1-ol:
• Biodegradability: Test Type: aerobic Inoculum: Activated sludge Concentration: 100 mg/l Result: Readily biodegradable. Biological degradation: 79 - 99.9 % Exposure time: 14 d Method: OECD Guideline 301 C

12.3 Bioaccumulation Potential

Substances:

• 2-Ethylhexan-1-ol:
• Bioaccumulation: Remarks: No data available
• Partition Coefficient: n-Octanol/Water: log Pow: 2.9 (25 °C) pH Value: 7.0 Method: OECD Guideline 117 Remarks: Bioaccumulation is not expected.

12.4 Mobility in Soil

No data available

12.5 Results of PBT and vPvB Assessment

Product:

• Assessment: This substance/mixture does not contain any components that, in concentrations of 0.1% or higher, are classified as persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB).

12.6 Endocrine Disrupting Properties

Product:

• Assessment: The substance/mixture does not contain any components that, according to REACH Article 57(f) or Commission Delegated Regulation (EU) 2017/2100 or Commission Delegated Regulation (EU) 2018/605, have endocrine-disrupting properties in quantities of 0.1% or more.

12.7 Other Adverse Effects

Product:

• Other Ecological Advice: Avoid release to the environment.

SECTION 13: Disposal Considerations

13.1 Waste Treatment Methods

Product: Product residues must be disposed of in accordance with national and regional regulations. Keep chemicals in original containers. Do not mix with other waste. Uncleaned containers must be treated as the product itself. Observe Waste Directive 2008/98/EC.

SECTION 14: Transport Information

14.1 UN Number or ID Number

14.2 UN Proper Shipping Name

14.3 Transport Hazard Class(es)

14.4 Packing Group

14.5 Environmental Hazards

14.6 Special Precautions for User

The transport classification(s) provided herein are for informational purposes only and are based solely on the properties of the unpackaged material as described in this Safety Data Sheet. Transport classifications may vary with transport method, packaging size, and regional or country-specific regulations.

14.7 Mass Transport of Goods by Sea in Accordance with IMO Instruments

Not applicable to the product in its delivered state.

SECTION 15: Regulatory Information

15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance or Mixture

• REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, mixtures and articles (Annex XVII): The conditions for restriction for the following entries should be considered: Number in List 3
• REACH - List of Substances of Very High Concern (SVHC) for authorisation (Article 59): Not applicable
• Regulation (EC) No. 2024/590 on substances that deplete the ozone layer: Not applicable
• Regulation (EU) 2019/1021 on persistent organic pollutants (Recast): Not applicable
• REACH - Candidate List of Substances of Very High Concern for Authorisation (Annex XIV): Not applicable
• Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances: Not applicable

Water Hazard Class: WGK 1 slightly hazardous to water
Number: 134
Classification according to AwSV §6(4)

15.2 Chemical Safety Assessment

No chemical safety assessment has been carried out for this product.

SECTION 16: Other Information

Full text of other abbreviations and acronyms:

• 2017/164/EU: European Parliament and Council Directive 2017/164/EU establishing a fourth list of indicative occupational exposure limit values.
• DE DFG MAK: Germany. MAK and BAT Annex IIa
• DE TRGS 900: Germany. TRGS 900 - Occupational Exposure Limits - 8-hour values
• 2017/164/EU / TWA:
• DE DFG MAK / MAK: MAK value
• DE TRGS 900 / AGW: Occupational exposure limit
• ADN: European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways;
• IATA: Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for Testing and Materials; bw - body weight; CLP - Regulation on Classification, Labelling and Packaging of Substances, Regulation (EC) No 1272/2008; CMR - Carcinogenic, Mutagenic or Toxic to Reproduction; DIN - German Institute for Standardization; DSL - Domestic Substances List (Canada); ECHA - European Chemicals Agency; EC Number - Number of the European Community; ECx - Concentration of a response, related to x % response; ELx - Loading rate associated with x % response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration of response, related to x % growth rate; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer;
• International Air Transport Association:
• IBC: International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG Code - International Maritime Dangerous Goods Code; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organization for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50% of a test population; LD50 - Lethal Dose to 50% of a test population (median lethal dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - not otherwise specified; NO(A)EC - Concentration, at which no (adverse) effect is observed; NO(A)EL - Dose at which no (adverse) effect is observed; NOELR - No observed effect loading rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention (OSCPP); PBT - Persistent, Bioaccumulative and Toxic substances; PICCS - Philippine Inventory of Chemicals and Chemical Substances;