Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name: Hydrogen fluoride (65% solution in pyridine) for synthesis

Product Number: 8.18068

Brand: Millipore

Other Names: No data available

Intended Use: Chemical synthesis

Supplier Details:

Manufacturer, Importer, or Supplier: Taiwan Merck Co., Ltd.

Address: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, TAIWAN

MERCK LTD.

Address: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, Taiwan

Merck KGaA

Address: 64271 Darmstadt, Germany

Phone: +49 6151 72-0

Fax: +886 2-8751-6262

Emergency Contact:

Emergency Phone Number: CHEMTREC: 00801 49 1821, CHEMTREC Taipei: +886 2 7741 4207

Section 2: Hazard Identification

Hazard Classification:

• Flammable liquid: Category 2
• Acute toxicity (oral): Category 2
• Acute toxicity (inhalation): Category 2
• Acute toxicity (dermal): Category 1
• Skin corrosion/irritation: Category 1A
• Serious eye damage/eye irritation: Category 1

Label Elements:

Hazard Pictograms: ⚠️??

Signal Word: Danger

Hazard Statements:

• H225 Highly flammable liquid and vapor.
• H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled.
• H314 Causes severe skin burns and eye damage.

Precautionary Statements:

• Prevention:
• P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P233 Keep container tightly closed.
• P240 Ground/bond container and receiving equipment.
• P241 Use explosion-proof electrical/ventilating/lighting/equipment.
• P242 Use only non-sparking tools.
• P243 Take precautionary measures against static discharge.
• P260 Do not breathe dust/fume/gas/mist/vapors/spray.
• P262 Do not get in eyes, on skin, or on clothing.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/protective clothing/eye protection/face protection.
• P284 Wear respiratory protection.
• Response:
• P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Rinse mouth.
• P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
• P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
• P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor/physician.
• P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
• P361 + P364 Take off immediately all contaminated clothing and wash it before reuse.
• P370 + P378 In case of fire: Use dry sand, dry powder or alcohol-resistant foam to extinguish.
• Storage:
• P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
• P403 + P235 Store in a cool, well-ventilated place.
• P405 Store locked up.
• Disposal:
• P501 Dispose of contents/container to an approved waste disposal plant.

Section 3: Composition/Information on Ingredients

Mixture

Hazardous Components:

Section 4: First-Aid Measures

General Advice: Immediately take precautionary measures. Self-protection for the rescuer. Show this safety data sheet to the doctor in attendance.

Inhalation: Move victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Seek immediate medical attention.

Skin Contact: Immediately flush skin with plenty of water for at least 10 minutes. Remove and wash contaminated clothing. Apply calcium gluconate gel (prepared by boiling 5g calcium gluconate in 85ml distilled water, adding 10g glycerin. Swell 5g sodium carboxymethylcellulose in this hot solution, store in a cool place for 6 months) and massage the skin until pain subsides. If pain subsides, apply gel for another 15 minutes. If calcium gluconate gel is not available, use 20% calcium gluconate soaked dressing.

Eye Contact: Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove contact lenses. Continue rinsing. Seek immediate medical attention!

Ingestion: Immediately give large amounts of water to drink, supplement with calcium (calcium gluconate or calcium lactate). Caution: Vomiting may cause perforation! Give more calcium gluconate solution. Laxative: Sodium sulfate (1 tablespoon/quarter liter of water). Seek immediate medical attention. Keep the patient at rest and warm. See also symptoms and effects, section 11.

Protection for First-Aiders: See Section 8.

Notes to Physician: Advise physician to consult with a doctor experienced in treating hydrofluoric acid injuries. If systemic effects are suspected, the patient must be very carefully monitored and treated. Note! Electrolyte imbalance may cause ventricular fibrillation.

Section 5: Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, carbon dioxide (CO2), dry powder.

Unsuitable Extinguishing Media: None specified.

Special Hazards Arising from the Substance or Mixture: The mixture contains combustible components.

Hazardous Combustion Products: Hydrogen fluoride, nitrogen oxides, carbon oxides. Beware of flashback. Vapors are heavier than air and may spread along the ground. Flammable gases or vapors may be generated during a fire.

Section 6: Accidental Release Measures

Personal Precautions: Do not breathe vapor, mist, gas or spray. Avoid contact with substance. Ensure adequate ventilation. Keep away from heat and ignition sources. Evacuate danger area, follow emergency procedures, consult expert.

Environmental Precautions: Do not allow product to enter drains. Risk of explosion.

Methods for Containment and Cleaning Up: Cover drains. Collect, absorb, pump spilled material. Follow possible substance use restrictions (see Sections 7 and 10). Absorb with liquid-absorbing material and neutralizing agent (e.g., Chemizorb® HF, Merck product number 101591), and dispose of as chemical waste, cleaning the affected area.

Section 7: Handling and Storage

Precautions for Safe Handling: Keep away from flames, hot surfaces, and ignition sources. Take measures to prevent static discharge. Handle in a fume hood. Avoid breathing vapor or mist. Avoid generating vapor or aerosol.

Conditions for Safe Storage: Keep container tightly closed in a dry, well-ventilated place. Keep away from heat and ignition sources. Store in a place that can be locked or accessible only to authorized personnel.

Storage Class: 3, Flammable liquid

Recommended Storage Temperature: Refer to product label.

Further Information on Storage Stability: Refer to product label.

Section 8: Exposure Controls/Personal Protection

Occupational Exposure Limits:

Biological Indicators:

Engineering Controls: No data available.

Personal Protective Equipment:

• Respiratory Protection: Required when vapor/aerosol is generated. Recommended filter type: ABEK type filter. Ensure that respirators are maintained, cleaned, and tested according to manufacturer's instructions and that these measures are properly documented.
• Hand Protection: Material: Butyl rubber. Breakthrough time: 240 min. Glove thickness: 0.7 mm. Splash contact. Manufacturer: Butoject® (KCL 898). Note: This information is only valid for Merck products and the restrictions specified in the Safety Data Sheet. For mixtures, dissolution, or other situations not covered by EN 16523-1, please contact the CE-certified glove supplier (e.g., German glove supplier KCL Company, website: www.kcl.de).
• Eye Protection: Use equipment tested and approved by official standards such as NIOSH (USA) or EN 166 (EU). Tight-fitting safety goggles.
• Skin and Body Protection: Flame-retardant anti-static protective clothing. Rubber or plastic boots.
• Hygiene Measures: Immediately remove and wash contaminated clothing. Use skin protection lotion. Wash hands and face thoroughly after using this substance.

Section 9: Physical and Chemical Properties

Appearance: Liquid

Color: Colorless

Odor: Characteristic

Odor Threshold: No data available

pH Value: < 7 (20 °C)

Melting Point: No data available

Boiling Point/Boiling Range: No data available

Flash Point (Test Method): 20 °C (1,013 hPa) Method: Closed cup, ISO 1523

Evaporation Rate: No data available

Flammability (solid, gas): No data available

Explosion Limits: No data available

Vapor Pressure: No data available

Vapor Density: No data available

Relative Density: No data available

Density: 1.14 g/cm3 (20 °C)

Solubility:

• Water Solubility: Soluble (20 °C)

Octanol/Water Partition Coefficient: No data available

Auto-ignition Temperature: No data available

Decomposition Temperature: > 50 °C

Dynamic Viscosity: No data available

Kinematic Viscosity: No data available

Flow Time: No data available

Explosive Properties: Non-explosive.

Oxidizing Properties: None.

Section 10: Stability and Reactivity

Reactivity: See Section 10.3. Vapor may form explosive mixtures with air.

Chemical Stability: The product is chemically stable under standard atmospheric conditions (room temperature).

Possibility of Hazardous Reactions: Risk of fire or generation of flammable gases or vapors.

Conditions to Avoid: Heat, sparks, open flames, and hot surfaces. Avoid static discharge.

Incompatible Materials: Metals, alkali metals, fluorine, halogen-halogen compounds, chlorosulfonic acid, chromium(VI) oxide, fuming sulfuric acid, chromic acid, nitric acid, sulfuric acid, silver salts, perchlorates, nitrogen dioxide. Reaction with the following materials can cause explosion/exothermic reactions: potassium permanganate, silicides, alkaline hydroxides, phosphorus oxides, bismuth acid, strong bases, perchloric acid, nitrogen oxides. May react violently with the following substances: oxidizing agents, acid anhydrides, halogenated acids.

Hazardous Decomposition Products: Upon combustion: see Section 5 Fire-Fighting Measures. Glass, metals, quartz/silicate ceramics, rubber. Reacts with metals to release hydrogen.

Section 11: Toxicological Information

Mixture

Acute Toxicity:

• Acute toxicity estimate (oral) - 7.83 mg/kg (Calculation method)
• Symptoms: Ingestion may cause severe burns to the mouth and throat, and perforation of the esophagus and stomach.
• Acute toxicity estimate (inhalation) - 4 h - 0.906 mg/l - vapor (Calculation method)
• Symptoms: Irritation of mucous membranes, cough, shortness of breath, possible damage to the respiratory tract.
• Acute toxicity estimate (dermal) - 7.83 mg/kg (Calculation method)

Skin Corrosion/Irritation: Note: The mixture causes severe burns.

Serious Eye Damage/Eye Irritation: Note: The mixture causes severe eye damage. Risk of blindness!

Respiratory or Skin Sensitization: No data available.

Germ Cell Mutagenicity: No data available.

Carcinogenicity: No data available.

Reproductive Toxicity: No data available.

Specific Target Organ Toxicity - Single Exposure: No data available.

Specific Target Organ Toxicity - Repeated Exposure: No data available.

Aspiration Hazard: No data available.

Additional Information: Other hazards cannot be excluded. Handle with particular care. Operate in accordance with industrial hygiene and safety practices.

Substance: Hydrofluoric acid

Acute Toxicity:

• Oral: No data available.
• LC50 Inhalation - Rat - 4h - 0.58 mg/l - vapor (ECHA)
• Acute toxicity estimate (dermal) - 5.1 mg/kg (Expert judgment)
• Note: Classification according to (EU) 1272/2008 Regulation, Annex VI, Table 3.1 / 3.2

Skin Corrosion/Irritation:

• Skin - Rabbit
• Result: Causes burns. - 4h (OECD Test Guideline 404)
• Note: Classification according to (EU) 1272/2008 Regulation, Annex VI, Table 3.1 / 3.2
• Note: Symptoms may be delayed.

Possible Damage: Necrosis. This substance penetrates and causes wounds that are difficult to heal.

Serious Eye Damage/Eye Irritation:

• Eye - Rabbit
• Result: Causes burns. (OECD Test Guideline 405)
• Note: (IUCLID)
• Note: Causes severe eye damage.

Respiratory or Skin Sensitization: No data available.

Germ Cell Mutagenicity:

• Test Type: Bacterial reverse mutation assay (AMES)
• Test System: Salmonella typhimurium
• Result: Negative
• Test Type: In vitro mammalian chromosome aberration test
• Test System: Chinese hamster ovary cells
• Result: Positive results were obtained in some in vitro tests.
• Species: Rat
• Note: Cytogenetic analysis

Carcinogenicity: No data available.

Reproductive Toxicity: No data available.

Specific Target Organ Toxicity - Single Exposure: No data available.

Specific Target Organ Toxicity - Repeated Exposure: No data available.

Aspiration Hazard: No data available.

Substance: Pyridine

Acute Toxicity:

• Oral LD50 - Rat - 1,500 mg/kg (ECHA)
• Symptoms: Vomiting, nausea.
• LC50 Inhalation - Rat - Male - 4h - 17.1 mg/l - vapor (US-EPA)
• Symptoms: Irritation of mucous membranes, cough, shortness of breath.
• Dermal LD50 - Rabbit - > 1,000 - 2,000 mg/kg (OECD Test Guideline 402)

Skin Corrosion/Irritation:

• Skin - Rabbit
• Result: Slight skin irritation - 24 h (Draize test)

Serious Eye Damage/Eye Irritation:

• Eye - Rabbit
• Result: Eye irritation. - 24h (ECHA)

Respiratory or Skin Sensitization:

• Local Lymph Node Assay (LLNA) - Mouse
• Result: Negative
• (OECD Test Guideline 429)

Germ Cell Mutagenicity:

• Test Type: Bacterial reverse mutation assay (AMES)
• Test System: Salmonella typhimurium
• Result: Negative
• Test Type: In vitro mammalian chromosome aberration test
• Test System: Chinese hamster lung cells
• Result: Negative
• Method: OECD Test Guideline 475
• Species: Mouse - Male - Bone marrow
• Result: Negative

Carcinogenicity: No data available.

Reproductive Toxicity: No data available.

Specific Target Organ Toxicity - Single Exposure: Acute oral toxicity - vomiting, nausea. Acute inhalation toxicity - irritation of mucous membranes, cough, shortness of breath.

Specific Target Organ Toxicity - Repeated Exposure: No data available.

Aspiration Hazard: No data available.

Section 12: Ecological Information

Ecotoxicity:

Substance: Hydrofluoric acid:

• Toxicity to other aquatic invertebrates: NOEC (Daphnia magna): 3.7 mg/l. Endpoint: Reproduction rate. Exposure time: 21 d. Test type: Static test. Note: (ECHA)

Substance: Pyridine:

• Toxicity to fish: EC50 (Danio rerio): 560 - 1,000 mg/l. Endpoint: Mortality. Exposure time: 96 h. Test type: Semi-static test. Method: OECD Test Guideline 203. GLP Laboratory: Yes. Note: (Comparison with similar products)
• Toxicity to other aquatic invertebrates: EC50 (Daphnia magna): 320 mg/l. Endpoint: Immobilization. Exposure time: 48 h. Method: OECD Test Guideline 202. GLP Laboratory: Yes. Note: (Comparison with similar products)
• Toxicity to algae/aquatic plants: EC50 (Pseudokirchneriella subcapitata): 320 mg/l. Exposure time: 72 h. Test type: Static test. Method: OECD Test Guideline 201. GLP Laboratory: Yes. Note: (Comparison with similar products)

Persistence and Degradability:

Substance: Hydrofluoric acid: Note: Biodegradation test methods are not applicable to inorganic substances.

Substance: Pyridine:

• Biodegradability: Aerobic. Inoculum: activated sludge. Result: Rapid biodegradation. Biodegradability: 97%. Exposure time: 28 d. Method: OECD Test Guideline 301B.

Bioaccumulative Potential:

Substance: Hydrofluoric acid: Note: Not applicable to inorganic substances.

Substance: Pyridine:

• Octanol/water partition coefficient: log Pow: approx. 0.64 (20 °C). pH value: 7. Method: (Experimental). Note: (Lit.) Estimated to have low bioaccumulative potential.

Mobility in Soil: No data available.

Other Adverse Effects: No data available.

Additional Ecological Information:

• Substance: Hydrofluoric acid: Ecotoxicity: Due to pH changes, toxic effects are produced. Even diluted, it forms toxic corrosive mixtures with water. If released into soil or water, it poses a hazard to drinking water. Prevent release into the environment.
• Substance: Pyridine: PBT and vPvB assessment results: According to EU Regulation (EC) No 1907/2006, Annex XIII, the substance does not meet the PBT or vPvB criteria.

Section 13: Disposal Considerations

Waste Treatment Methods: Disposal of this product must be carried out in accordance with waste disposal regulations. Disposal of waste must comply with national and local regulations. Store chemical products in their original containers and do not mix with other waste. Dispose of contaminated containers in the same manner as the product. Waste disposal must comply with national and local regulations. Keep chemical waste in original containers and do not mix with other waste. Dispose of contaminated containers in the same manner as the product.

Section 14: Transport Information

UN Number: UN 1790

UN Proper Shipping Name: Hydrofluoric acid

Transport Hazard Class(es): 8

Subsidiary Risk(s): 6.1

Packing Group: I

Label(s): Class 8 - Corrosive substances, Division 6.1 - Toxic substances

Packing Instructions: Cargo aircraft: 854, Passenger aircraft: 850

IMDG Code:

• UN Number: UN 1790
• UN Proper Shipping Name: HYDROFLUORIC ACID
• Transport Hazard Class(es): 8
• Subsidiary Risk(s): 6.1
• Packing Group: I
• Label(s): 8 (6.1)
• EmS Number: F-A, S-B
• Marine Pollutant: No

According to MARPOL 73/78 Annex II and IBC Code: Not applicable to the product supplied.

Special Precautions for User: Transport classification provided herein is for reference only, based on the nature of the un-packaged material described in this Safety Data Sheet. Transport classification may vary due to transport mode, package size, and regional or national regulations.

Section 15: Regulatory Information

Applicable Regulations:

• Occupational Safety and Health Act: Applicable
• Occupational Safety and Health Facilities Rules: Applicable
• Waste Disposal Act: Applicable
• Standards for Storage and Disposal of Industrial Waste: Applicable
• Regulations on Hazardous Chemical Labeling and Communication: Applicable
• Hazardous Chemical Assessment and Classification Management: Applicable
• Road Traffic Safety Rules: Applicable
• Regulations on Permissible Exposure Limits for Laborers: Applicable
• Prevention of Organic Solvent Poisoning: Applicable
• Prevention of Specific Chemical Substance Hazards: Not applicable
• Standards and Safety Management for Placement of Public Hazardous Materials and Compressed Gases: Controlled by quantity
• Toxic and Concerned Chemical Substances Control Act: Applicable
• Toxic Chemical Substances: Applicable
• Concerned Chemical Substances: Applicable
• Designation and Operation Management of Priority Management Chemicals: Applicable
• Labor Health Protection Act: Not applicable

Section 16: Other Information

Further Information:

• References: Please refer to the respective chapters for references.
• The information in this document is based on our current knowledge and is intended to provide guidance on the safe handling of this product. This information does not constitute a guarantee of all properties of the product. Users should independently assess its suitability for their intended use, and Merck does not warrant that this product provides any proprietary rights.

Prepared by/Contact Person:

• Name: Merck KGaA LS-QH Department
• Address/Phone: 64271 Darmstadt Germany / +49 6151 72-0

Date of Preparation: 2025.07.16

Other Information: The information provided herein is considered accurate but may not be exhaustive and is intended as a guide only. The information in this document is based on our current knowledge and is intended to provide guidance on the safe handling of this product. This information does not constitute a guarantee of all properties of the product. Sigma-Aldrich and its affiliates are not liable for any damages arising from any operation or contact with the above product. For further terms of use, please refer to the invoice or the back of the packaging. For further sales terms and conditions, please refer to www.sigma-aldrich.com or the back of the ticket or packing slip. Copyright: 2020 Sigma-Aldrich Co. LLC. All rights reserved. Paper copying is permitted for internal use only.

Date Format: Year/Month/Day

Full text of abbreviations and acronyms:

• ACGIH: American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Values (TLV)
• ACGIH BEI: ACGIH - Biological Exposure Indices (BEI)
• TW OEL: Occupational Exposure Limit Value in Taiwan
• ACGIH / TWA: 8-hour time-weighted average
• ACGIH / C: Ceiling limit
• TW OEL / TWA: 8-hour time-weighted average
• TW OEL / STEL: Short-term exposure limit
• AIIC: Australian Inventory of Industrial Chemicals; ANTT: Brazilian National Land Transport Agency; ASTM: American Society for Testing and Materials; bw: body weight; CMR: Carcinogenic, Mutagenic or Reprotoxic substances; DIN: German Institute for Standardization; DSL: Domestic Substances List (Canada); ECx: Concentration of effect x%; ELx: Load of effect x%; EmS: Emergency Schedule; ENCS: Existing and New Chemical Substances (Japan); ErCx: Concentration of growth effect x%; ERG: Emergency Response Guidebook; GHS: Globally Harmonized System of Classification and Labelling of Chemicals; GLP: Good Laboratory Practice; IARC: International Agency for Research on Cancer; IATA: International Air Transport Association; IBC: International Bulk Chemical Code; IC50: Half maximal inhibitory concentration; ICAO: International Civil Aviation Organization; IECSC: Inventory of Existing Chemical Substances in China; IMDG: International Maritime Dangerous Goods; IMO: International Maritime Organization; ISHL: Industrial Safety and Health Law (Japan); ISO: International Organization for Standardization; KECI: Korean Existing Chemicals Inventory; LC50: Lethal Concentration 50%; LD50: Lethal Dose 50%; MARPOL: International Convention for the Prevention of Pollution from Ships; n.o.s.: not otherwise specified; Nch: Chilean certification; NO(A)EC: No Observed Adverse Effect Concentration; NO(A)EL: No Observed Adverse Effect Level; NOELR: No Observed Effect Level; NOM: Mexican Official Standard; NTP: National Toxicology Program; NZIoC: New Zealand Inventory of Chemicals; OECD: Organisation for Economic Co-operation and Development; OPPTS: Office of Prevention, Pesticides and Toxic Substances; PBT: Persistent, Bioaccumulative and Toxic substances; PICCS: Philippine Inventory of Chemicals and Chemical Substances; (Q)SAR: Quantitative Structure-Activity Relationship; REACH: Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; SADT: Self-Accelerating Decomposition Temperature; SDS: Safety Data Sheet; TCSI: Taiwan Chemical Substance Inventory; TDG: Transport of Dangerous Goods; TECI: Thailand Existing Chemical Inventory; TSCA: Toxic Substances Control Act (USA); UN: United Nations; UNRTDG: United Nations Recommendations on the Transport of Dangerous Goods; vPvB: very Persistent and very Bioaccumulative chemical substance; WHMIS: Workplace Hazardous Materials Information System.

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