Millipore SAFETY DATA SHEET

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name: Ethanol absolute for analysis EMSURE® ACS, ISO, Reag. Ph Eur

Product Number: 100983

Brand: Millipore

Index-No.: 603-002-00-5

REACH No.: 01-2119457610-43-XXXX

CAS-No.: 64-17-5

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses: Reagent for analysis, Chemical production

1.3 Details of the supplier of the safety data sheet

Company: Merck KGaA, Frankfurter Str. 250, D-64271 DARMSTADT

Telephone: +49 (0)6151 72-0

Fax: +49 6151 727780

E-mail address: TechnicalService@merckgroup.com

1.4 Emergency telephone number

Emergency Phone #: +(44)-870-8200418 (CHEMTREC (GB)), +(353)-19014670 (CHEMTREC Ireland), 001-803-017-9114 (CHEMTREC India)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Flammable liquids, (Category 2) - H225: Highly flammable liquid and vapour.

Eye irritation, (Category 2) - H319: Causes serious eye irritation.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008

Pictogram: [Flame symbol] [Exclamation mark symbol]

Signal Word: Danger

Hazard Statements: H225: Highly flammable liquid and vapour. H319: Causes serious eye irritation.

Precautionary Statements:

• P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P233: Keep container tightly closed.
• P240: Ground and bond container and receiving equipment.
• P241: Use explosion-proof electrical/ ventilating/ lighting equipment.
• P242: Use non-sparking tools.
• P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Supplemental Hazard Statements: none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Ecological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

Toxicological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances

Formula: C2H6O

Molecular weight: 46,07 g/mol

CAS-No.: 64-17-5

EC-No.: 200-578-6

Index-No.: 603-002-00-5

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice: Show this safety data sheet to the doctor in attendance.

If inhaled: After inhalation: fresh air.

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media: Water, Foam, Carbon dioxide (CO2), Dry powder

Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides. Combustible. Pay attention to flashback. Vapours are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

5.3 Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information: Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on protection against fire and explosion: Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.

Hygiene measures: Change contaminated clothing. Wash hands after working with substance. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions: Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.

Recommended storage temperature: see product label.

Storage class: Storage class (TRGS 510): 3: Flammable liquids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

8.2 Exposure controls

Personal protective equipment

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection: This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact: Material: butyl-rubber, Minimum layer thickness: 0,7 mm, Break through time: 480 min, Material tested: Butoject® (KCL 898)

Splash contact: Material: Nitrile rubber, Minimum layer thickness: 0,4 mm, Break through time: 120 min, Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)

Body Protection: Flame retardant antistatic protective clothing.

Respiratory protection: Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Control of environmental exposure: Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Physical state: liquid

b) Color: colourless

c) Odor: alcohol-like

d) Melting point/freezing point: -114,0 °C at 1.013,25 hPa

e) Initial boiling point and boiling range: 78,29 °C at 1.013 hPa

f) Flammability (solid, gas): No data available

g) Upper/lower flammability or explosive limits: Upper explosion limit: 27,7 %(V), Lower explosion limit: 3,1 %(V)

h) Flash point: 13 °C - closed cup - closed cup

i) Autoignition temperature: 363 °C at 1.013 hPa

j) Decomposition temperature: Distillable in an undecomposed state at normal pressure.

k) pH: 7,0 at 10 g/l at 20 °C

l) Viscosity: Viscosity, kinematic: No data available, Viscosity, dynamic: 1,2 mPa.s at 20 °C

m) Water solubility: 1.000 g/l at 20 °C - completely miscible

n) Partition coefficient: n-octanol/water: log Pow: -0,35 at 24 °C - Bioaccumulation is not expected.

o) Vapor pressure: 57,26 hPa at 19,6 °C

p) Density: 0,79 g/cm3 at 20 °C

q) Relative vapour density: No data available

r) Particle characteristics: No data available

s) Explosive properties: Not classified as explosive.

t) Oxidizing properties: none

9.2 Other safety information

Conductivity: < 1 µS/cm

Surface tension: 22,31 mN/m at 20 °C - similar to water

Relative vapour density: 1,6

SECTION 10: Stability and reactivity

10.1 Reactivity

Vapours may form explosive mixture with air.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature).

10.3 Possibility of hazardous reactions

Risk of explosion/exothermic reaction with: hydrogen peroxide, perchlorates, perchloric acid, Nitric acid, mercury(II) nitrate, permanganic acid, Nitriles, peroxi compounds, Strong oxidizing agents, nitrosyl compounds, Peroxides, sodium, Potassium, halogen oxides, calcium hypochlorite, nitrogen dioxide, metallic oxides, uranium hexafluoride, iodides, Chlorine, Alkali metals, Alkaline earth metals, alkali oxides, Ethylene oxide, silver.

With Nitric acid, silver compounds.

With Ammonia, potassium permanganate.

With conc. sulfuric acid.

Risk of ignition or formation of inflammable gases or vapours with: halogen-halogen compounds, chromium(VI) oxide, chromyl chloride, Fluorine, hydrides, Oxides of phosphorus, platinum, Nitric acid.

With potassium permanganate.

10.4 Conditions to avoid

Warming.

10.5 Incompatible materials

No data available

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity:

• LD50 Oral - Rat - male and female - 10.470 mg/kg (OECD Test Guideline 401)
• LC50 Inhalation - Rat - male and female - 4 h - 124,7 mg/l - vapour (OECD Test Guideline 403)
• Dermal: No data available

Skin corrosion/irritation:

• Skin - Rabbit: Result: No skin irritation - 24 h (OECD Test Guideline 404)

Serious eye damage/eye irritation:

• Eyes - Rabbit: Result: Causes serious eye irritation. (OECD Test Guideline 405)

Respiratory or skin sensitization:

• Maximisation Test - Guinea pig: Result: negative (OECD Test Guideline 406)
• Remarks: (in analogy to similar products). The value is given in analogy to the following substances: Methanol

Germ cell mutagenicity:

• Test Type: Ames test, Test system: Salmonella typhimurium, Metabolic activation: with and without metabolic activation, Method: OECD Test Guideline 471, Result: negative
• Test Type: In vitro mammalian cell gene mutation test, Test system: mouse lymphoma cells, Metabolic activation: with and without metabolic activation, Method: OECD Test Guideline 476, Result: negative
• Test Type: dominant lethal test, Species: Mouse, Application Route: Oral, Method: OECD Test Guideline 478, Result: Positive results were obtained in some in vivo tests.

Carcinogenicity: No data available

Reproductive toxicity: No data available

Specific target organ toxicity - single exposure: No data available

Specific target organ toxicity - repeated exposure: No data available

Aspiration hazard: No data available

11.2 Additional Information

Endocrine disrupting properties:

• Product: Assessment: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

Repeated dose toxicity - Rat - male - Oral - No observed adverse effect level - 1.730 mg/kg, Lowest observed adverse effect level - 3.200 mg/kg. Irritant effects, respiratory paralysis, Dizziness, narcosis, inebriation, euphoria, Nausea, Vomiting.

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity

• Toxicity to fish: flow-through test LC50 - Pimephales promelas (fathead minnow) - 15.300 mg/l - 96 h (US-EPA)
• Toxicity to daphnia and other aquatic invertebrates: static test LC50 - Ceriodaphnia dubia (water flea) - 5.012 mg/l - 48 h. Remarks: (ECHA)
• Toxicity to algae: static test ErC50 - Chlorella vulgaris (Fresh water algae) - 275 mg/l - 72 h (OECD Test Guideline 201)
• Toxicity to bacteria: static test IC50 - activated sludge > 1.000 mg/l - 3 h (OECD Test Guideline 209)
• Toxicity to fish(Chronic toxicity): semi-static test NOEC - Danio rerio (zebra fish) - 250 mg/l - 120 h. Remarks: (ECHA)
• Toxicity to daphnia and other aquatic invertebrates(Chronic toxicity): semi-static test NOEC - Daphnia magna (Water flea) - 9,6 mg/l - 9 d. Remarks: (ECHA)

12.2 Persistence and degradability

Biodegradability: aerobic Exposure time 15 d. Result: ca.95 % - Readily biodegradable. (OECD Test Guideline 301E)

Biochemical Oxygen Demand (BOD): 930 - 1.670 mg/g. Remarks: (Lit.)

Theoretical oxygen demand: 2.100 mg/g. Remarks: (Lit.)

12.3 Bioaccumulative potential

Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

Product: Assessment: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No interference with wastewater treatment plants are to be expected when used properly. Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

No data available

SECTION 14: Transport information

14.1 UN number: ADR/RID: 1170, IMDG: 1170, IATA: 1170

14.2 UN proper shipping name: ADR/RID: ETHANOL, IMDG: ETHANOL, IATA: Ethanol

14.3 Transport hazard class(es): ADR/RID: 3, IMDG: 3, IATA: 3

14.4 Packaging group: ADR/RID: II, IMDG: II, IATA: II

14.5 Environmental hazards: ADR/RID: no, IMDG Marine pollutant: no, IATA: no

14.6 Special precautions for user: Tunnel restriction code: (D/E). Further information: No data available

14.7 Maritime transport in bulk according to IMO instruments: Not applicable for product as supplied.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

National legislation: Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. P5c FLAMMABLE LIQUIDS

15.2 Chemical safety assessment

A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements

• H225: Highly flammable liquid and vapour.
• H319: Causes serious eye irritation.

Full text of other abbreviations

ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response; ELx - Loading rate associated with x% response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x% growth rate response; GHS - Globally Harmonised System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organisation; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organisation for Standardisation; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

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