Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Identification

Chemical Name: 1,3-Dimethyl-2-imidazolidinone for synthesis

Product Number: 8.18212

Item Number: 818212

Brand: Millipore

Other Names: No data available

Recommended Use and Restrictions on Use

Recommended Use: Chemical synthesis

Details of the Supplier of the Safety Data Sheet

Manufacturer, Importer or Supplier: Taiwan Merck Co., Ltd.

Name, Address, and Phone Number: 20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, TAIWAN

MERCK LTD.

20F., No. 121, Jingmao 2nd Road, Nangang District, Taipei City 115, Taiwan

Merck KGaA

64271 Darmstadt Germany

Contact Information

Phone: +49 6151 72-0

Fax: +886 2-2162-1111

Emergency Contact Number

Emergency Phone Number: CHEMTREC: 00801 49 1821

CHEMTREC Taipei: +886 2 7741 4207

Section 2: Hazards Identification

Product Hazard Classification

Acute Toxicity (Oral): Category 4

Serious Eye Damage/Eye Irritation: Category 1

Reproductive Toxicity: Category 1B

Label Elements

Hazard Pictograms: ☠️ ?️ ⚠️

Signal Word: Danger

Hazard Statements:

• H302 Harmful if swallowed.
• H318 Causes serious eye damage.
• H360 May damage fertility or the unborn child.

Precautionary Statements:

Prevention:

• P201 Obtain special instructions before use.
• P202 Do not handle until all safety precautions have been read and understood.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response:

• P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.
• P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
• P308 + P313 IF exposed or concerned: Get medical advice/attention.

Storage:

• P405 Store locked up.

Disposal:

• P501 Dispose of contents/container to an approved waste disposal plant.

Other Hazards

No reports.

Section 3: Composition/Information on Ingredients

Substance/Mixture: Substance

Component

Section 4: First-Aid Measures

General Advice: Show this safety data sheet to the doctor in attendance.

First-Aid Measures by Different Exposure Routes

Inhalation: After inhalation: Move the victim to fresh air. Seek immediate medical attention.

Skin Contact: Under skin contact: Immediately remove all contaminated clothing. Rinse skin with water/shower. Consult a doctor.

Eye Contact: After eye contact: Rinse with plenty of water. Immediately contact an ophthalmologist. Remove contact lenses.

Ingestion: After ingestion: If the victim vomits, beware of the risk of aspiration of vomit! Keep the airway clear. Aspiration of vomit may cause lung failure. Call a doctor immediately.

Most Important Symptoms and Effects

See label and Section 11 for the most important symptoms and effects.

Protection for First-Aid Personnel

See Section 8 for personal protection.

Notes to Physician

No data available.

Section 5: Fire-Fighting Measures

Suitable Extinguishing Media: Water, Foam, Carbon Dioxide (CO2), Dry Powder

Unsuitable Extinguishing Media: No restrictions on extinguishing media for this substance or mixture.

Special Hazards Arising from the Substance or Mixture: Combustible material.

Hazardous Combustion Products:

• Oxides of nitrogen
• Nitrous oxides

Special Fire Fighting Procedures: Spray water to suppress gas/vapor/mist. Prevent fire-fighting water from entering surface water and groundwater systems.

Special Protective Equipment for Firefighters: Personnel not wearing self-contained breathing apparatus should not enter the danger area. To avoid skin contact, maintain a safe distance or wear appropriate protective clothing.

Section 6: Accidental Release Measures

Personal Precautions:

• For non-emergency personnel: Do not inhale vapor, aerosol. Avoid contact with the substance. Ensure adequate ventilation. Evacuate the danger area, follow emergency procedures, consult a professional.
• For emergency responders: See Section 8 for personal protection.

Environmental Precautions: Do not allow product to enter drains.

Methods and Materials for Containment and Cleaning Up: Cover drains. Collect, absorb, pump up spilled material. Observe the limitations of use for the substance (see Sections 7 and 10). Absorb with liquid absorbent material (e.g., Merck Chemizorb®) and dispose of as chemical waste, cleaning the affected area.

Section 7: Handling and Storage

Precautions for Safe Handling

Handling: Operate in a fume hood. Avoid inhalation of substance/mixture. Avoid generating vapor/aerosol.

Storage:

• Conditions for Safe Storage: Keep container tightly closed. Store in a well-ventilated place. Store in a place that can be locked or accessible only to authorized personnel.
• Storage Class: 6.1C, Combustible, Acute Toxic Category 3 / Toxic compounds or compounds causing chronic effects.
• Recommended Storage Temperature: Storage temperature: refer to product label.
• Further Information on Storage Stability: Storage temperature: refer to product label.

Section 8: Exposure Controls/Personal Protection

Occupational Exposure Limit Values for Components

No substances with occupational exposure limit values are present.

Biological Indicators

No substances with biological indicators are present.

Engineering Controls: No data available.

Personal Protective Equipment

Respiratory Protection: To be used when vapor/aerosol is generated. Recommendations for filter respirators are based on the following standards: DIN EN 143, DIN 14387 and other standards related to respiratory protective equipment.

Recommended Filter Type: Wear an A-type filter for organic compound vapors (DIN 3181 standard).

Hand Protection

Material: Butyl rubber

Permeation Time: 480 min

Glove Thickness: 0.7 mm

Protection Index: Complete contact

Manufacturer: Butoject® (KCL 898)

Material: Nitrile rubber

Permeation Time: 30 min

Glove Thickness: 0.4 mm

Protection Index: Splash contact

Manufacturer: Camatril® (KCL 730 / Aldrich Z677442, Size M)

Notes: This information is only valid for Merck products and their limitations as stated in the safety data sheet. When mixed with other substances, dissolved, or in cases not covered by EN 16523-1, please contact the CE-certified glove supplier (e.g., German glove supplier KCL GmbH, website: www.kcl.de).

Eye Protection: Use equipment tested and approved by official standards such as NIOSH (USA) or EN 166 (EU) for eye protection. Tight-fitting safety goggles.

Skin and Body Protection: Wear protective clothing.

Hygiene Measures: Immediately change contaminated clothing. Use skin protection lotion. Wash hands and face after using this substance.

Section 9: Physical and Chemical Properties

Appearance: Liquid

Color: Colorless

Odor: Characteristic

Odor Threshold: No data available

pH Value: Neutral

Melting Point: 8.2 °C

Boiling Point/Boiling Range: 106 - 108 °C (23 hPa)

Flash Point (Test Method): 104 °C (Closed Cup)

Evaporation Rate: No data available

Flammability (Solid, Gas): No data available

Flammability (Liquid): No data available

Vapor Pressure: < 1 hPa (20 °C)

Vapor Density: No data available

Relative Density: 1.06

Density: 1.056 g/cm3 (20 °C)

Solubility:

Water Solubility: 1,000 g/l Miscible in all proportions (25 °C)

Partition Coefficient (n-octanol/water): log Pow: -0.31 (25 °C)

Auto-ignition Temperature: 305 °C

Decomposition Temperature: No data available

Viscosity:

Dynamic Viscosity: 2.07 mPa.s (20 °C)

1.51 mPa.s (40 °C)

Kinematic Viscosity: 1.43 mm2/s (40 °C)

1.95 mm2/s (20 °C)

Explosive Properties: Non-explosive

Oxidizing Properties: None

Molecular Weight: 114.15 g/mol

Particle Characteristics:

Particle Size: No data available

Section 10: Stability and Reactivity

Reactivity: Forms explosive mixtures with air upon rapid heating.

Stability: Classified as critical within the range of approximately 15 K (absolute temperature) below the flash point.

The product is chemically stable under standard atmospheric conditions (room temperature).

Possibility of Hazardous Reactions: May react violently with the following substances: Strong oxidizing agents, Phosphorus halides, Chlorine.

Conditions to Avoid: Strong heating.

Incompatible Materials: No data available.

Hazardous Decomposition Products: Upon combustion: see Section 5 Fire-fighting measures.

Section 11: Toxicological Information

Information on Toxicological Effects

Acute Toxicity:

• Oral LD50 - Rat - Female - 300 - 2,000 mg/kg (OECD Test Guideline 423)
• Inhalation: No data available
• Dermal LD50 - Rabbit - Male - > 2,000 mg/kg (OECD Test Guideline 434)

Skin Corrosion/Irritation:

• Skin - Rabbit
• Result: Slight irritation - 4h (OECD Test Guideline 404)

Serious Eye Damage/Eye Irritation:

• Eyes - Rabbit
• Result: Causes serious eye damage. (OECD Test Guideline 405)

Respiratory or Skin Sensitization:

• Respiratory or Skin Sensitization
• Result: No data available

Germ Cell Mutagenicity:

• Test Type: Bacterial Reverse Mutation Test (AMES)
• Test System: Escherichia coli / Salmonella typhimurium
• Metabolic Activation: With or without metabolic activation
• Result: Negative
• Remarks: (ECHA)
• Test Type: Mutagenicity (Mammalian Cell Micronucleus Test):
• Test System: Chinese Hamster Lung Cells
• Metabolic Activation: With or without metabolic activation
• Method: OECD Test Guideline 473
• Result: Negative
• Test Type: In vitro Mammalian Cell Gene Mutation Test
• Test System: Mouse Lymphoma Assay
• Metabolic Activation: With or without metabolic activation
• Method: OECD Test Guideline 476
• Result: Negative

Carcinogenicity: No data available

Reproductive Toxicity: May damage fertility or the unborn child.

Specific Target Organ Toxicity - Single Exposure: No data available

Specific Target Organ Toxicity - Repeated Exposure: No data available

Aspiration Hazard: No data available

Additional Information:

Repeated Dose Toxicity - Rat - Male - Oral - 28 d - No Observed Adverse Effect Level - 30 mg/kg

Section 12: Ecological Information

Toxicity

Component:

1,3-Dimethyl-2-imidazolidinone:

• Toxicity to Fish: LC50 (Oryzias latipes): > 100 mg/l
• Endpoint: Mortality
• Exposure Time: 96 h
• Test Type: Semi-static Test
• Method: OECD Test Guideline 203
• GLP: Yes
• Toxicity to Daphnia and Other Aquatic Invertebrates: EC50 (Daphnia magna): > 100 mg/l
• Endpoint: Immobilization
• Exposure Time: 48 h
• Test Type: Static Test
• Method: OECD Test Guideline 202
• GLP: Yes
• NOEC (Daphnia magna): >= 100 mg/l
• Endpoint: Immobilization
• Exposure Time: 48 h
• Test Type: Static Test
• Method: OECD Test Guideline 202
• GLP: Yes
• Toxicity to Algae/Aquatic Plants: ErC50 (Desmodesmus subspicatus): > 100 mg/l
• Exposure Time: 72 h
• Test Type: Static Test
• Method: OECD Test Guideline 201
• GLP: Yes

Ecological Toxicity Assessment

Hazard to the aquatic environment (chronic toxicity): NOEC (activated sludge): 1,000 mg/l

Exposure Time: 3h

Test Type: Static Test

Method: OECD Test Guideline 209

GLP: Yes

This product has no known ecological effects.

Persistence and Degradability:

Component:

1,3-Dimethyl-2-imidazolidinone:

• Biodegradability: Readily biodegradable
• Inoculum: Activated sludge
• Result: Not readily biodegradable.
• Biodegradability: 5%
• Exposure Time: 28 d
• Method: OECD Test Guideline 301F
• GLP: Yes

Bioaccumulative Potential:

Component:

1,3-Dimethyl-2-imidazolidinone:

• Bioaccumulation: Cyprinus carpio (Carp)
• Bioconcentration Factor (BCF): < 0.37
• Temperature: 25°C
• Partition Coefficient (n-octanol/water): log Pow: -0.31 (25 °C)
• Method: OECD Test Guideline 107
• GLP: Yes
• Remarks: No bioaccumulation potential is expected.

Mobility in Soil: No data available

Other Adverse Effects: Depending on the concentration, phosphates or nitrogen compounds may cause eutrophication of water sources. Prevent discharge into the environment.

Section 13: Disposal Considerations

Waste Treatment Methods

Disposal of Waste: Disposal of waste must comply with national and local regulations. Keep chemical waste in its original container and do not mix with other waste. Dispose of contaminated containers in the same manner as the product. This product must be disposed of according to waste disposal regulations. Disposal of waste must comply with national and local regulations. Store chemicals in their original containers and do not mix with other waste. Dispose of contaminated containers in the same manner as the product.

Section 14: Transport Information

International Regulations

Air Transport (IATA-DGR): Not applicable

UN/ID Number: Not applicable

Proper Shipping Name: Not applicable

Transport Hazard Class(es): Not applicable

Subsidiary Risk(s): Not applicable

Packing Group: Not applicable

Labeling: Not applicable

Packaging Instructions (Cargo Aircraft): Not applicable

Packaging Instructions (Passenger Aircraft): Not applicable

Sea Transport (IMDG-Code):

UN Number: Not applicable

Proper Shipping Name: Not applicable

Transport Hazard Class(es): Not applicable

Subsidiary Risk(s): Not applicable

Packing Group: Not applicable

Labeling: Not applicable

EmS Number: Not applicable

Marine Pollutant (Yes/No): No

According to MARPOL 73/78 Annex II and IBC Code: Not applicable to the product supplied.

Special Transport Precautions and Notes: Not classified as a dangerous good according to transport regulations.

Section 15: Regulatory Information

Applicable Regulations

Occupational Safety and Health Act: Applicable

Occupational Safety and Health Facility Regulations: Applicable

Waste Disposal Act: Applicable

Standards for Storage and Disposal of Industrial Waste and Facilities: Applicable

Hazardous Chemical Labeling and Information Dissemination Rules: Applicable

Hazardous Chemical Assessment and Classification Management: No substances with occupational exposure limit values.

Road Traffic Safety Rules: Not applicable

Occupational Exposure Limit Standards for Workplaces: Not applicable

Regulations for the Prevention of Organic Solvent Poisoning: Not applicable

Regulations for the Prevention of Hazards from Specific Chemical Substances: Not applicable

Standards and Safety Management Regulations for the Installation of Public Dangerous Goods and Flammable High-Pressure Gas Manufacturing, Storage, and Handling Facilities: Quantity controlled

Regulations on Management of Toxic and Concerned Chemical Substances:

• Toxic Chemical Substances: Not applicable
• Concerned Chemical Substances: Not applicable

Designation and Operation Management Regulations for Priority Management Chemicals: Applicable

Labor Health Protection Rules: Not applicable

Section 16: Other Information

Further Information:

Information in this document is based on our current knowledge and is intended to provide guidance on the proper safety precautions for this product. This information does not constitute a guarantee of all properties of the product. Users should independently assess its suitability for their specific applications and it does not constitute Merck's warranty of any intellectual property rights for this product.

Copyright: 2020 Sigma-Aldrich Co. LLC. Permission is granted for unlimited paper copying, for internal use only.

Date Format: Year/Month/Day

Full text of other abbreviations:

AIIC - Australian Inventory of Industrial Chemicals; ANTT - Brazilian National Land Transport Agency; ASTM - American Society for Testing and Materials; bw - body weight; CMR - Carcinogenic, Mutagenic or Reprotoxic substances; DIN - German Institute for Standardization; DSL - Canada Domestic Substances List; ECx - Concentration of effect x%; ELx - Load of effect x%; EmS - Emergency Schedule; ENCS - Japan Existing and New Chemical Substances List; ErCx - Concentration of growth effect x%; ERG - Emergency Response Guidebook; GHS - Globally Harmonized System of Classification and Labelling of Chemicals; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Bulk Chemical Code; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - China Inventory of Existing Chemical Substances; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Japan Industrial Safety and Health Act; ISO - International Organization for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration Fifty; LD50 - Lethal Dose Fifty; MARPOL - International Convention for the Prevention of Pollution from Ships; MERCOSUR - Southern Common Market - Agreement on the Transport of Dangerous Goods; n.o.s. - not otherwise specified; Nch - Chilean Certification; NO(A)EC - No Observed Adverse Effect Concentration; NO(A)EL - No Observed Adverse Effect Level; NOELR - No Observed Effect Level of Exposure; NOM - Mexican Official Standard; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Prevention, Pesticides and Toxic Substances; PBT - Persistent, Bioaccumulative and Toxic chemicals; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - Quantitative Structure-Activity Relationship; REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation (EC) 1907/2006; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TDG - Dangerous Goods Transport; TECI - Thailand Existing Chemical Inventory; TSCA - United States Toxic Substances Control Act; UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - very Persistent and very Bioaccumulative chemicals; WHMIS - Workplace Hazardous Materials Information System.

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