ZEISS arivis: Customize, Automate, Scale Microscopy Image Analysis

Key Advantages

• User-friendly AI workflows with Deep Learning support.
• No coding required.
• High-quality image visualization and analysis (including 4D and well plates).
• Optimized computational resource utilization.
• Flexible, powerful analysis pipelines incorporating deep learning.
• Simplified automation, scalability, and handling of large datasets.
• Centralized storage and data access for seamless collaboration.

Streamline analysis, avoid repetitive manual steps, reduce human bias, optimize computation, and save time with automated analysis for 2D, 3D, or 4D images.

Create AI models on ZEISS arivis Cloud or locally in ZEISS arivis Pro and integrate them into advanced image analysis pipelines for reproducible results. Explore data with a productive virtual reality solution. Scale and automate analysis to process thousands of images with ZEISS arivis Hub. Centralized data access and management facilitate collaboration, allowing refinement of shared models, visualization, and real-time review.

Analyze Images from Any System or Manufacturer

• Confocal Microscopy
• Widefield Microscopy
• Lightsheet Microscopy
• Electron Microscopy
• Computed Tomography (CT and μCT)
• X-ray Microscopy
• Multiphoton Microscopy

Image Analysis Software For Various Applications

• Cell Biology
• Developmental Biology
• Cancer Research
• Neuroscience
• Immunology
• Translational Research
• Physiology
• Materials Science & Electronics
• And many other fields.

ZEISS arivis Pro: Powerful Image Analysis & Visualization

ZEISS arivis Pro offers advanced analysis and visualization for large data and demanding tasks, supporting 2D, 3D, and 4D images. Create powerful pipelines with user-friendly tools, leveraging customized or pre-trained AI models. Python scripting is available for specific needs. Virtual reality (VR) provides an immersive analysis experience. The software supports numerous file formats.

Key Features:

• Click-and-play solution for routine or customized workflows.
• Combine different operations (denoising, segmentation, filtering) in a clear pipeline with interactive preview.
• Boost research with AI, using customized or open-source models (e.g., Cellpose).
• No coding needed; intuitive interface, with options for scripted code.
• Supports over 45 file formats.
• Repeat analysis with one click for consistent, quantitative data.

ZEISS arivis Pro VR: Immersive Sample Exploration

Explore and analyze samples in an interactive virtual reality environment. Share and discuss results in real-time with colleagues. Control interactions via voice or VR tools for a new perspective. Improved tracking and proofreading enhance accuracy. VR Stories offer presentation and video capabilities.

• Gain a new perspective with an immersive VR experience.
• Create ground truth 3D annotations for deep learning model training.
• Observe details from diverse angles.
• Collaborate for live review of samples and results.
• Easy voice and hands-on control.
• Effective for proofreading and editing automatic analysis results.
• OpenXR support.

Advanced Features:

• Enhanced Cell Track Editing and Proofreading in VR: Quantify cell division and migratory phenotypes, track changes in 2D/3D images. Accurately proofread tracks or segment data in VR. Modify tracks by cutting, merging, or prolonging them.
• Automatic Neuron Tracing: Analyze comprehensive structural networks in 2D/3D multichannel images. AI-assisted spine tracing manages big data, detecting and tracing neurons. Features two state-of-the-art algorithms, AI-assisted spine tracing, quick preview, semi-automatic trace editing, wide variety of trace measurements, and extensive visualization/export options.
• Flexibility in AI Analysis: Import diverse AI models to create pipelines for segmenting 2D/3D datasets. Train AI models using ZEISS arivis Cloud or local tools. AI-assisted annotation is available. Exchange models (e.g., ZEISS CZANN, ONNX, Cellpose, Stardist).

ZEISS arivis Cloud: Easily Train Your Own AI Models

Train customized AI models using ZEISS arivis Cloud to automate image segmentation. AI-driven image analysis ensures reproducibility and reliability. Deep Learning handles tasks previously impossible with conventional methods.

Key Features:

• Train Deep Learning models with an intuitive interface, no coding or prior knowledge required.
• Annotate quickly using AI-assisted annotation tools.
• Cutting-edge, cloud-based solution with the latest AI algorithms and high data safety.
• Rapid results through automation of routine tasks.
• Collaborate with colleagues to refine shared models and training datasets.
• Integrate AI models into ZEN, ZEN core, or ZEISS arivis Pro, and scale up on ZEISS arivis Hub.

AI-assisted Annotation: Save time with AI-assisted annotation. Annotate examples, review results, and tweak as needed. Add, modify, or erase annotations. Automatically subtract annotated regions from background annotations. Review results side-by-side.

Pixel-based and Object-based Segmentation: Train semantic (pixel-based) or instance (object-based) segmentation models. These models can be integrated into workflows for measurements (count, size, shape) or tracking.

ZEISS arivis Hub: Scalable, Automated Processing

Consolidate imaging data for accelerated throughput, improved efficiency, and faster results. ZEISS arivis Hub offers centralized storage and data management with automatic data ingestion and analysis for various file types. Optimize resource allocation for maximum computing potential and cost control.

Key Features:

• Automated Workflows: Folder watching detects and processes images with automated analysis pipelines.
• Scalable Analysis: Add modules and parallel processing power as needed.
• Collaboration: Web-based access for easy sharing of images and analysis data.

Parallelized Batch Processing: Handle large volumes of data efficiently. Deploy multiple processing machines for parallel analysis. Scale processors up or down for faster turnaround times and controlled resource usage.

• Import customized AI-powered pipelines from ZEISS arivis Pro for scaled, automated analysis.
• Handle large datasets with ease.
• Optimize computing resources offsite and onsite.

High Content Analysis: Train AI models and automate image analysis for drug discovery, saving time, reducing bias, and ensuring consistent results. Features include flexible integration of robotics, automated workflows, AI-driven segmentation, live-cell imaging, well-plate analysis, and parallelized batch processing.

Advanced Analysis Examples

• DNA Foci Assay: Segment foci and nuclei in 3D using AI models. Quantify relationships across diverse conditions.
• Phenotyping Screening: Monitor cell phenotype changes across drug treatments. AI ensures reproducible results.
• Organoid Volume Quantification: Analyze organoids for cell layer formation and single-cell effects with AI for improved downstream quantification.
• Cell Confluency, Cell or Nuclei Counting: Quantify cell confluency and count cells or nuclei easily with AI. Apply to time series and multi-well plate data.
• High-Content Genotoxicity: Measure signal intensity of foci in two channels to determine DNA damage. Stratify nuclei based on parameters for mechanistic analysis. Pipeline can be scaled.
• Sub-cellular Analysis: Use Deep Learning models to segment sub-cellular objects. Classify objects using quantitative features.

Institutional Licenses

Streamline AI-powered analysis with subscription-based Institutional Licenses for ZEISS arivis Pro and Cloud. Enjoy cost savings, flexible workspace allocation with floating licenses, and always up-to-date features. Adjust software packages and seat counts annually.

• ZEISS arivis Pro: Annual subscription includes all Pro modules for advanced analysis of large 3D datasets.
• ZEISS arivis Cloud: Annual subscription provides accessible AI for image analysis with no coding, including Deep Learning Toolset, expert support, and access to new features and training materials.

Solutions Lab: Rapid Application Development

Automate and enhance workflows with customized microscopy software solutions. ZEISS Solutions Lab drives innovation for automation and workflow integration across life sciences, materials sciences, and industrial R&D. Solutions include feedback loops for image acquisition, segmentation, analysis, reporting, and data export. Integrate robotics and automation processes.

Customized Solutions: Experts develop tailored applications to streamline imaging processes, utilize advanced analysis tools, automate ROI searches, adapt workflows, and simplify tasks.

Service and Support

ZEISS offers reliable equipment and expertise. Talk to an expert for consultation, training, and product information.

• Free Consultation: Image analysis and computation experts assist in setting up software solutions.
• Training and Product Information: Free training, tutorials, videos available on YouTube and the website. Product documentation in the knowledge base.
• Solutions Lab: Customized solution integration including hardware and software.
• Service Maintenance Agreement (ZEISS arivis Pro): Ensures two software updates per year, access to tutorials and knowledge base, expert support, and compatibility for new modules.