1. Introduction
This manual provides essential information for setting up, operating, and maintaining your MSI PRO DP21 Mini Business Desktop. Please read this guide thoroughly before using the product to ensure proper functionality and longevity.

Image 1.1: Front and rear view of the MSI PRO DP21 Mini Business Desktop, showcasing its compact design and various ports.
2. Package Contents
Verify that all items are present in your product package:
- MSI PRO Desktop Unit
- Wired Keyboard
- Wired Mouse
- Power Adapter
- User Manual (this document)
3. Product Overview
The MSI PRO DP21 is a compact business desktop designed for efficiency and versatility. It features a 13th Gen Intel Core i7-13700 processor, 16GB DDR4 RAM, and a 512GB PCIe NVMe M.2 SSD, running on Windows 11 Pro.

Image 3.1: Overview of key features including processor, memory, storage, wireless capabilities, and physical dimensions.
3.1. Front and Rear Panel Ports
Familiarize yourself with the available ports for connecting peripherals and displays.

Image 3.2: Detailed diagram illustrating the location and type of all front and rear panel ports.
- Front Ports:
- 1x Headphone-out
- 1x Mic-in
- 4x USB 2.0 Type-A
- Rear Ports:
- 1x DC Jack (Power Input)
- 1x HDMI-out (2.0b)
- 1x DisplayPort (1.4)
- 1x RJ45 (Ethernet)
- 1x USB 3.2 Gen 2 Type-C
- 1x USB 3.2 Gen 2 Type-A
- 2x USB 3.2 Gen 1 Type-A
- 1x Mic-in
- 1x Line-out
- 1x COM Port
3.2. Dimensions and Mounting
The compact design allows for flexible placement. The desktop supports VESA mounting for attachment to compatible monitors or walls.

Image 3.3: The MSI PRO DP21 demonstrating VESA bracket support for space-saving installation.
4. Setup
Follow these steps to set up your MSI PRO DP21 desktop:
- Connect Peripherals: Plug in the wired keyboard and mouse to any available USB Type-A ports on the front or rear panel.
- Connect Display: Connect your monitor(s) to the HDMI-out or DisplayPort on the rear panel. The system supports up to two 4K monitors simultaneously.
- Connect Power: Plug the power adapter into the DC Jack on the rear panel, then connect the power cord to an electrical outlet.
- Power On: Press the power button located on the front panel. The system will boot into Windows 11 Pro.
- Initial Windows Setup: Follow the on-screen instructions to complete the Windows 11 Pro setup, including language, region, network connection, and user account creation. For network, you can use Wi-Fi 6 or connect an Ethernet cable to the RJ45 port.
5. Operating Instructions
5.1. Power Management
- Power On: Press the power button on the front panel.
- Shut Down: Click the Start button in Windows, then select Power > Shut down.
- Restart: Click the Start button in Windows, then select Power > Restart.
- Sleep: Click the Start button in Windows, then select Power > Sleep.
5.2. Display Configuration
The MSI PRO DP21 supports dual monitor setups. To configure your displays in Windows 11 Pro:
- Right-click on an empty area of the desktop and select "Display settings."
- Under "Multiple displays," you can detect, identify, and arrange your monitors.
- Choose your preferred display option (e.g., Extend these displays, Duplicate these displays).
5.3. Network Connectivity
Your desktop supports both wired and wireless network connections.
- Wi-Fi: To connect to a wireless network, click the Wi-Fi icon in the taskbar, select your desired network, and enter the password if prompted. The system supports Wi-Fi 6 (802.11ax).
- Ethernet: Connect an Ethernet cable from your router or modem to the RJ45 port on the rear panel for a wired connection.

Image 5.1: The desktop in a modern office setting, emphasizing its seamless integration and Wi-Fi 6 connectivity.
6. Maintenance
Regular maintenance helps ensure optimal performance and extends the lifespan of your desktop.
- Cleaning:
- Use a soft, dry cloth to clean the exterior of the desktop.
- For dust accumulation in vents, use compressed air. Ensure the system is powered off before cleaning.
- Avoid using liquid cleaners directly on the device.
- Software Updates: Regularly check for and install Windows updates to ensure system security and performance. Go to Settings > Windows Update.
- Storage Management: Periodically clean up unnecessary files and applications to free up storage space and maintain system speed. Windows offers built-in tools like Disk Cleanup.
- Hardware Upgrades: The system supports up to 64GB Dual Channel DDR4 RAM and up to 2TB PCIe M.2 SSD for future expansion. Consult a qualified technician for hardware upgrades.

Image 6.1: Illustration of potential RAM and SSD upgrade capabilities for enhanced performance.
7. Troubleshooting
If you encounter issues with your MSI PRO DP21, refer to the following common solutions:
| Problem | Possible Solution |
|---|---|
| No Power | Ensure the power adapter is securely connected to both the desktop and a working electrical outlet. Test the outlet with another device. |
| No Display | Verify that the monitor is powered on and the video cable (HDMI/DisplayPort) is securely connected to both the desktop and the monitor. Try a different video cable or monitor if possible. |
| No Internet Connection | For Wi-Fi, check if Wi-Fi is enabled in Windows settings and if you are connected to the correct network. For wired, ensure the Ethernet cable is properly connected and your router/modem is functioning. |
| Peripherals Not Working | Try connecting the keyboard or mouse to a different USB port. Ensure drivers are up to date (Windows Update). |
| System Slowdown | Check for background applications, perform a disk cleanup, and ensure Windows is fully updated. Consider checking for malware. |
If problems persist, please contact MSI customer support for further assistance. You can find support information on the official MSI website.
8. Specifications
Detailed technical specifications for the MSI PRO DP21 Mini Business Desktop (Model: MS-B0A4).
| Feature | Detail |
|---|---|
| Processor | Intel Core i7-13700 (16 Cores, 24 Threads, up to 5.2GHz) |
| Graphics | Intel UHD Graphics (Integrated) |
| RAM | 16 GB DDR4 (3200 MHz) |
| Storage | 512 GB PCIe NVMe M.2 SSD |
| Operating System | Windows 11 Pro |
| Wireless Connectivity | Wi-Fi 6 (802.11ax), Bluetooth 5.3 |
| Video Output | 1x HDMI 2.0b, 1x DisplayPort 1.4 (Supports 2-Monitor 4K) |
| USB Ports | 4x USB 2.0 Type-A, 1x USB 3.2 Gen 2 Type-C, 1x USB 3.2 Gen 2 Type-A, 2x USB 3.2 Gen 1 Type-A |
| Other Ports | 1x RJ45, 1x COM Port, 2x Audio Jacks (Mic-in, Headphone-out) |
| Dimensions (LxWxH) | 8.03 x 8.19 x 2.16 inches |
| Weight | 8 pounds |
| Power Source | AC Adapter |
9. Warranty and Support
MSI products are designed for reliability and performance. For warranty information and technical support, please refer to the official MSI website or the warranty card included with your product.
You can visit the official MSI store for additional product information and support resources: MSI Store on Amazon
For protection plans, options may be available from third-party providers. Please review their terms and conditions carefully.







