Introduction
The Targus Compact Multi-Device Bluetooth DefenseGuard Mouse (AMB581GL) is designed for enhanced productivity and versatility. It offers dual-mode wireless connectivity, supporting both 2.4 GHz and Bluetooth 5.0, allowing seamless connection to up to three different devices. Its compact, pebble-shaped design ensures comfortable use, while the integrated Targus DefenseGuard Antimicrobial Protection provides a cleaner surface that lasts for the product's lifetime.
This manual provides detailed instructions for the proper setup, operation, and maintenance of your mouse to ensure optimal performance and longevity.
Setup
1. Battery Installation
The mouse requires AAA batteries (not included). To install:
- Locate the battery compartment cover on the underside of the mouse.
- Slide the cover open.
- Insert the AAA batteries, ensuring correct polarity (+/-) as indicated inside the compartment.
- Close the battery compartment cover securely.

Image: Underside view of the mouse, highlighting the battery compartment and the mode switch. This view is crucial for battery installation and selecting the connection mode.
2. Connecting Your Mouse
The mouse supports two wireless connection modes: 2.4 GHz via a USB dongle (if included with your model) and Bluetooth 5.0. You can connect up to three devices simultaneously (one via 2.4 GHz and two via Bluetooth).
2.1. 2.4 GHz Wireless Connection
This method uses a dedicated USB receiver for a stable connection.
- Locate the USB receiver, typically stored inside the battery compartment of the mouse.
- Plug the USB receiver into an available USB port on your computer.
- Turn on the mouse using the power switch on the underside.
- Set the connectivity switch on the underside of the mouse to the '2.4G' position.
- Your computer should automatically detect and connect to the mouse.
2.2. Bluetooth Connection (BT1 / BT2)
This method allows connection to Bluetooth-enabled devices without a USB receiver.
- Turn on the mouse using the power switch on the underside.
- Set the connectivity switch on the underside of the mouse to either 'BT1' or 'BT2' position.
- Press and hold the pairing button (usually a small circular button near the mode switch) for 3-5 seconds until the LED indicator on the mouse begins to flash, indicating it is in pairing mode.
- On your device (computer, tablet, or smartphone), navigate to the Bluetooth settings.
- Search for new devices. The mouse should appear as 'Targus Mouse' or similar.
- Select the mouse to complete the pairing process.
- Repeat steps 2-6 for the 'BT2' channel to connect a second Bluetooth device.
Operating Your Mouse
Basic Functions
- Left Click: Primary selection and activation.
- Right Click: Accesses contextual menus.
- Scroll Wheel: Scrolls content vertically. The scroll wheel also functions as a middle click button.

Image: Top view of the mouse, illustrating the main click buttons and the scroll wheel for standard operation.
Switching Between Devices
To switch between connected devices (2.4 GHz, BT1, BT2), simply move the connectivity switch on the underside of the mouse to the desired channel (2.4G, BT1, or BT2). The mouse will automatically connect to the last paired device on that channel.
Battery Life Indicator
The mouse features a convenient battery life indicator, typically an LED light, which will alert you when the battery level is low, prompting you to replace the AAA batteries.
Maintenance
Cleaning
The Targus DefenseGuard Antimicrobial Protection helps keep the mouse surface cleaner. To clean the mouse, gently wipe it with a soft, damp cloth. Avoid using harsh chemicals, abrasive cleaners, or excessive moisture, as these can damage the device or compromise the antimicrobial properties.
Battery Replacement
When the battery indicator signals low power, replace the AAA batteries following the installation steps outlined in the Setup section. Always dispose of used batteries responsibly according to local regulations.
Troubleshooting
| Problem | Possible Cause | Solution |
|---|---|---|
| Mouse not responding | Low or dead batteries; Incorrect connection mode; USB receiver not plugged in (for 2.4 GHz); Bluetooth not paired. | Replace batteries; Ensure the mode switch is set correctly (2.4G, BT1, or BT2); Re-insert USB receiver; Re-pair Bluetooth device. |
| Cursor erratic or jumpy | Dirty optical sensor; Unsuitable surface; Interference. | Clean the optical sensor with a soft, dry cloth; Use the mouse on a clean, non-reflective, uniform surface; Move closer to the receiver/device or reduce other wireless interference. |
| Cannot pair via Bluetooth | Mouse not in pairing mode; Device's Bluetooth is off; Already connected to maximum devices. | Ensure mouse LED is flashing (pairing mode); Turn on Bluetooth on your device; Disconnect from other Bluetooth devices or use a different BT channel (BT1/BT2). |
| Short wireless range | Obstructions; Interference; Distance from receiver/device. | Ensure a clear line of sight between mouse and receiver/device; Move closer to the receiver/device; Avoid placing near other wireless devices. |
Specifications
| Feature | Detail |
|---|---|
| Model Number | AMB581GL |
| Brand | Targus |
| Connectivity Technology | 2.4 GHz Wireless, Bluetooth 5.0 |
| Number of Devices | Up to 3 (1 x 2.4 GHz, 2 x Bluetooth) |
| Movement Detection | Optical |
| Operating System Compatibility | Chrome OS, Mac OS, Windows |
| Power Source | Battery Powered (AAA batteries, not included) |
| Color | Black |
| Item Weight | 0.33 ounces (approx. 9.35 grams) |
| Product Dimensions (LxWxH) | 2.4 x 1.2 x 0.1 inches (approx. 6.1 x 3.05 x 0.25 cm) |
| Special Feature | DefenseGuard Antimicrobial Protection |
| Encryption | 128-bit AES-CCM |

Image: Side view of the mouse with dimension labels, indicating its compact size.
Warranty and Support
The Targus Compact Multi-Device Bluetooth DefenseGuard Mouse (AMB581GL) typically comes with a 2-year limited warranty. For specific warranty terms and conditions, please refer to the documentation included with your product or visit the official Targus website.
For technical support, troubleshooting assistance beyond this manual, or warranty claims, please visit the Targus support section on their official website or contact their customer service directly. Contact information and support resources are generally available on the manufacturer's website.







