1. Introduction
The Logitech Signature M650 L is a full-size wireless mouse designed for left-handed users, offering enhanced comfort and productivity. It features an adaptive SmartWheel for precise and fast scrolling, silent clicks, customizable side buttons, and versatile connectivity options.
Key Features:
- Adaptive SmartWheel: Provides line-by-line precision and switches to super-fast free-spin mode.
- Left-Handed Design: Ergonomically shaped for larger left hands.
- SilentTouch Technology: Reduces click noise by 90% for a quieter work environment.
- Dual Connectivity: Connects via Bluetooth Low Energy or Logi Bolt USB receiver.
- Customizable Side Buttons: Assign shortcuts using Logitech Options+ software.
- Long Battery Life: Up to 24 months on a single AA battery.
- Multi-Platform Compatibility: Works with Windows, macOS, Linux, ChromeOS, iPadOS, and Android.

Image: An annotated diagram highlighting key features of the Logitech Signature M650 L mouse, including the SmartWheel, silent clicking, Bluetooth connectivity, custom side buttons, comfort shape, and 24-month battery life.
2. What's in the Box
Verify that all items are present in the packaging:
- Signature M650 L LEFT Mouse
- Logi Bolt USB Receiver
- 1 x AA Battery (pre-installed or included separately)
- User Documentation
3. Setup
3.1. Battery Installation
The mouse typically comes with one AA battery pre-installed. If not, or if replacing the battery:
- Locate the battery compartment cover on the underside of the mouse.
- Slide or lift the cover to open the compartment.
- Insert one AA battery, ensuring correct polarity (+/-).
- Close the battery compartment cover securely.
3.2. Connecting Your Mouse
The Signature M650 L offers two connection methods: Logi Bolt USB Receiver or Bluetooth Low Energy.
Option 1: Logi Bolt USB Receiver
- Plug the Logi Bolt USB receiver into an available USB port on your computer.
- Turn on the mouse using the power switch on its underside. The LED indicator on the mouse should light up, indicating a successful connection.
Option 2: Bluetooth Low Energy
- Turn on the mouse using the power switch on its underside.
- Press and hold the connect button on the underside of the mouse for 3 seconds until the LED indicator starts blinking rapidly. This indicates the mouse is in pairing mode.
- On your computer or device, open Bluetooth settings.
- Select "Logitech M650 L" from the list of available devices and follow the on-screen prompts to complete pairing.

Image: An illustration depicting the Logitech Signature M650 L mouse with concentric circles radiating outwards, symbolizing wireless connectivity, alongside icons for Bluetooth and the Logi Bolt USB receiver.
3.3. Software Installation (Optional)
For advanced customization of buttons and other settings, download and install the Logitech Options+ software from the official Logitech website. This software is compatible with Windows and macOS.
3.4. Ergonomic Fit
The M650 L is specifically designed for larger left hands to provide optimal comfort during extended use. Ensure your hand rests naturally on the contoured shape and rubber side grips.

Image: A diagram illustrating hand size measurements (Small, Medium, Large) and their corresponding fit for the M650 and M650 L mouse models, indicating the M650 L is for larger hands.
4. Operating the Mouse
4.1. SmartWheel Scrolling
The SmartWheel automatically switches between two modes:
- Line-by-Line Precision: For detailed navigation in documents and spreadsheets.
- Super-Fast Free Spin: For quickly scrolling through long web pages or documents.
Simply flick the wheel to engage the super-fast mode, and it will revert to precision scrolling when you slow down.

Image: A close-up view of the Logitech Signature M650 L mouse's SmartWheel, emphasizing its textured surface and the 'SmartWheel' branding, set against a background of green and blue bars representing data or progress.
4.2. Customizable Side Buttons
The two side buttons on the mouse can be customized to perform various shortcuts, such as back/forward navigation, copy/paste, or other functions, using the Logitech Options+ software.

Image: A computer monitor displaying the Logitech Options+ software interface, showing how to customize the side buttons of the mouse to assign shortcuts like 'Back' or 'Forward'.
4.3. Silent Clicks
The Signature M650 L features SilentTouch technology, which reduces clicking noise by over 90% compared to traditional mice, allowing for a more focused and quiet working environment.

Image: A left hand operating the Logitech Signature M650 L mouse on a desk, with the 'SilentTouch' logo prominently displayed, indicating the quiet clicking feature.
4.4. Compatibility
The mouse is compatible with a wide range of operating systems, ensuring seamless integration into various computing environments.
- Windows 10, 11 or later
- macOS 10.15 or later
- Linux
- ChromeOS
- iPadOS 13.4 or later
- Android 8.0 or later

Image: A row of icons representing various operating systems (Windows, Apple, Linux, Android, Bluetooth), indicating the broad compatibility of the Logitech mouse.
5. Maintenance
5.1. Battery Replacement
When the mouse battery is low, the LED indicator may flash red. Replace the AA battery as described in Section 3.1. Battery life is approximately 24 months, but may vary based on usage.
5.2. Cleaning
To clean your mouse:
- Ensure the mouse is turned off.
- Use a soft, lint-free cloth lightly dampened with water or an approved electronic cleaning solution.
- Avoid using harsh chemicals, abrasive cleaners, or submerging the mouse in liquid.
- Gently wipe the surface of the mouse, paying attention to areas where dirt or grime may accumulate.
6. Troubleshooting
6.1. Connectivity Issues
- No Connection: Ensure the mouse is turned on and the battery has sufficient charge. For Logi Bolt, ensure the receiver is securely plugged in. For Bluetooth, ensure the mouse is in pairing mode and your device's Bluetooth is enabled.
- Intermittent Connection: Try moving the mouse closer to the receiver or your device. Avoid using the mouse on metal surfaces, which can interfere with wireless signals.
- Re-pairing: If connection is lost, try re-pairing the mouse using the steps in Section 3.2.
6.2. Scrolling or Button Issues
- SmartWheel Not Functioning: Ensure the mouse surface is clean and free of debris. If using Logitech Options+ software, check for any conflicting settings.
- Buttons Not Responding: Check battery level. If using custom settings, verify them in Logitech Options+. Try the mouse on a different computer to rule out software conflicts.
6.3. General Tips
- Restart your computer or device.
- Update your operating system and mouse drivers.
- If issues persist, refer to the official Logitech support website or the detailed user guide.
7. Specifications
| Feature | Detail |
|---|---|
| Brand | Logitech |
| Series | M650 L |
| Item Model Number | 910-006234 |
| Connectivity Technology | Bluetooth, USB (Logi Bolt) |
| Movement Detection Technology | Optical |
| Special Features | Lightweight, Portable, Soundless (Silent Clicks), Wireless |
| Color | Graphite |
| Item Weight | 3.92 ounces |
| Product Dimensions (LxWxH) | 1.6 x 2.6 x 0.1 inches |
| Power Source | Battery Powered |
| Batteries | 1 AA battery required (included) |
| Average Battery Life | 24 months |
| Hardware Platform | Linux, Mac, PC |
| Operating System | Chrome OS, Linux, Windows 10, Windows 11, iPadOS 13.4 |
8. Warranty and Support
Logitech products typically come with a limited hardware warranty. Please refer to the official Logitech website or the included user documentation for specific warranty terms and conditions applicable to your region.
For further assistance, technical support, or to download the latest software and drivers, visit the official Logitech support website.
Additional user documentation can be found here:
9. Official Product Videos
No official product videos from the seller were found to be relevant for inclusion in this instruction manual.






