Henry C. Farrar, MD, FAAP
January, 2011
Current Address
Dept. of Pediatrics, Slot 512-19A
Arkansas Children's Hospital
1 Children's Way
Little Rock, AR 72202-3591
Phone: (501) 364-1874 or (501) 364-1418
Email: FarrarHank@uams.edu
Current Position Title
Professor of Pediatrics
Pediatric Residency Director
Section of Pediatric Clinical Pharmacology
Section of Pediatric Emergency Medicine
University of Arkansas for Medical Sciences and Arkansas Children's Hospital
Education and Training
| Institution and Location | Degrees | Years | Field of Study |
|---|---|---|---|
| Harding University, Searcy, Arkansas | B.S. | 1976-1981 | Chemistry |
| Alliance Francaise, Paris, France | 1981-1982 | French | |
| Univ. of Arkansas for Medical Sciences, Little Rock | M.D. | 1982-1986 | Medicine |
| UAMS and Arkansas Children's Hospital | Residency | 1986-1989 | Pediatrics |
| University of Virginia, Charlottesville, Virginia | Fellowship | 1989-1991 | Clinical Pharmacology & Pediatric Emergency Med. |
| Rainbow Babies & Childrens Hosp., Cleveland, OH | Fellowship | 1991-1993 | Clinical Pharmacology & Pediatric Emergency Med. |
Academic Appointments at UAMS and ACH
- 1993 - 1999: Assistant Professor of Pediatrics
- 1999 - 2006: Associate Professor of Pediatrics
- 2006 - present: Professor of Pediatrics
- 1996 - 2006: Chief of Pediatric Clinical Pharmacology and Toxicology
- 1998 - 2004: UAMS Institutional Review Board for Clinical Research
- 1998 - 2004: Director, Junior Clerkship in Pediatrics
- 2004 - present: Director, Pediatric Residency Program
- 2006 - present: UAMS Graduate Medical Education Committee - Executive Committee
- 1995 - 2004: ACH Pharmacy and Therapeutics Committee
- 1997 - 2004, 2010: ACH Pharmacy/Therapeutics Committee, Drug Utilization Advisor
- 2006 - present: ACH Disaster Preparedness Program, Medical Command
- 2008 - present: ACH Patient Flow Committee
Awards and Honors
- Donald Hill Resident Award for Excellence in Research, 1989
- Red Sash for Medical Student Education (voted by graduating seniors) – 8 time recipient
- Department of Pediatrics, Educator of the Year, 2003
- "The Best Doctors in America” for Clinical Pharmacology
Licensure and Board Certifications
- Federal Licensing Examination in Medicine (FLEX); June, 1986
- Medical License; Arkansas State Medical Board since 1986
- American Board of Pediatrics, General Pediatrics 1989 (Recertified through 2011)
- American Board of Pediatrics, Sub-Board in Pediatric Emergency Med. 1994 (Recertified through 2015)
- American Board of Clinical Pharmacology, 1996
Professional Associations
American Academy of Pediatrics
- Section of Clinical Pharmacology and Therapeutics
- Executive Committee (1997-2003)
- Program Chair for National Meeting (NCE) (2000-2007)
- Organizer/Moderator for Section Program at the NCE (2003-2007)
- Nominations Chair (2007 - present)
- AAP Delegate to the US Pharmacopeia National Convention (2006 - present)
- Section of Pediatric Emergency Medicine
U.S. Food and Drug Administration
- Pediatric Advisory Committee (2008 - present)
- (Pediatric Healthcare Organization Representative)
UAMS Representative at National Educational Conferences
- Counsel on Medical Student Education in Pediatrics (1998-2004)
- Association of Pediatric Program Directors (2004 - present)
- APPD Regional Meeting in Memphis, TN (2004 - present)
- Accreditation Council on Graduate Medical Education (2004 - present)
Society Membership
- American Society for Clinical Pharmacology and Therapeutics
- American Academy of Clinical Toxicology
- Southern Society for Pediatric Research
- Central Arkansas Pediatric Society
Educational Activities
- Director, Fellowship in Pediatric Clinical Pharmacology (1995-1997)
- Director, Junior Clerkship in Pediatrics (1998-2004)
- Director, Pediatric Residency Program (2004 - present)
- Faculty Advisor for Senior Medical Students (1998 - 2004)
- UAMS Student Promotions Committee (1998 - present)
- UAMS Academic Standards Committee (2001 - present)
- UAMS Graduate Medical Education Committee (2004 - present)
- UAMS Graduate Medical Education Committee – Executive Committee (2006 - present)
- Chair, Subcommittee on Competency Training (2006-2008)
- Chair, Subcommittee on ACGME Citations (2008-present)
- UAMS Residency Internal Review Committee (2007 - present)
Current Standing Lectures and Educational Activities
Students
Junior - Toxicology Lecture (6/year), Resuscitation Skills Course (6/year)
Residents
Senior - Step 2 Review (Toxicology), Director of Longitudinal Elective in Pharmacology
Fellows
4-5 resident lectures/year, Journal Club Facilitator (monthly), Morning Report Leader
Primary Attending for Clinical Pharmacology Elective and Board Preparation Elective
Toxicology Review 4/year (Emergency Med)
Clinical Pharmacology Elective for Neonatal and Critical Care Fellows
Representative Invited Presentations
- 1995: UAMS/ACH Grand Rounds - Drug Interactions
- 1996: UAMS/ACH Grand Rounds - The Role of Therapeutic Drug Monitoring in Patient Care
- 1997: UAMS/ACH Grand Rounds - Acetaminophen Poisoning: Another Look at an Old Drug
- 1999: Heart Assoc Emergency Care - What's New in Emergency Cardiac Care
- 2000: State AAP Chapter Meeting - New Drugs You Should Know
- 2001: UAMS IRB Training - Protection of Vulnerable Subjects
- 2003: State AAP Chapter Meeting - New Drugs You Should Know
- 2006: UAMS/ACH Grand Rounds - The ACGME Core Competencies
- 2007: UAMS/ACH Grand Rounds - Learning Styles in Pediatric Education
Research Activities
Extramural Grants
- Recipient of a DHHS Training Grant in Clinical Pharmacology and Toxicology (#1T32 GMO 8260-01) during fellowship, 7/1/90 to 6/30/91.
- National Institutes of Child Health and Development: Associate Clinical Investigator from 1993 to 1994, Network of Pediatric Pharmacology Research Units (PPRU), Amount: $(b)(6) % salary support
- Pharmaceutical Research & Manufacturer's of America Foundation: Research Starter Grant, 1994. Principal Investigator, Title: The toxicity and metabolism of benzene in cultured bone marrow cells: an evaluation of the differences between DBA/2J and C57BL/6J mice. Amount: $(b)(4) for 1994 and $(b)(4) renewal for 1995
Educational Grants
- Arkansas Medical Society Distinguished Lecture Series – Requested and received a yearly grant of $(b)(4) to support invited guest lecturers from 1999 to 2004.
- Medical Education Foundation Fund of Arkansas (2000) and Char Foundation (2001) – Sought and received support for equipment purchases for medical student and resident education for a total of $(b)(4)
- UAMS Founder's Society Education Grant – $(b)(4) initially (2002) and renewed for $(b)(4) (2003). Project: To support equipment purchases needed to establish a pediatric resuscitation training program for the junior medical students.
- Medical Education Foundation Fund of Arkansas (2004) - $(b)(4) to develop a workshop on professionalism for junior medical students.
Intramural Grants
- Shared Equipment Grants to support research infrastructure for a total of $(b)(4)
- UAMS Dean's/Children's University Medical Group; Clinician Initiated Research Grant, 1994. Role: Principal Investigator, Title: The optimal dosing regimen of succimer in children with lead poisoning. Amount: $(b)(4)
- UAMS Dean's/Children's University Medical Group; Clinician Initiated Research, 2003. (Grant awarded but returned when I became residency director due to lack of research time) Role: Principal Investigator, Title: Mechanisms of Anticonvulsant-Related Delayed Hypersensitivity Reactions, Amount: $(b)(4)
Sponsored Clinical Trials
I have been the Principal Investigator on industry-sponsored clinical trials for total revenues of $(b)(4). These trials are not listed for reasons of confidentiality.
Bibliography (not including abstracts)
Original Research Publications
- Farrar HC, Wells TG, Kearns GL. Safety and efficacy of continuous infusion pralidoxime for the treatment of organophosphate poisoning in children. Journal of Pediatrics 1990;116:658-661.
- Farrar HC, Chande VC, Fitzpatrick D, Shema SJ. Hyponatremia as the etiology of seizures in infants: a retrospective analysis of the incidence, severity and clinical predictors. Annals of Emergency Medicine 1995;26:42-48.
- James LP, Farrar HC, Komoroski E, Wood R, Graham CJ, Bornemeier R, Valentine JL. Sympathomimetic drug use in adolescents presenting to a pediatric emergency department with chest pain. Journal of Toxicology - Clinical Toxicology 1998;36:321-328.
- Schexnayder S, James LP, Kearns GK, Farrar HC. The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate poisoning. Journal of Toxicology - Clinical Toxicology 1998;36:549-555.
- Maish WA, McCubbin MM, Letzig LG, Farrar HC, Kearns GL. Famotidine pharmacokinetics in patients with cystic fibrosis. Journal of Clinical Pharmacology 1998;38:1010-1016.
- James LP, Marotti T, Stowe CD, Farrar HC, Taylor BJ, Kearns GL. Pharmacokinetics and pharmacodynamics of famotidine in infants. Journal of Clinical Pharmacology 1998;38:1089-1095.
- Farrar HC, McLeane LR, Wallace M, White K, Watson J. Standard and pulse succimer therapy in lead poisoning. Journal of Clinical Pharmacology 1999;39:180-183.
- Farrar HC, James LP. Characteristics of pediatric admissions for cyclic antidepressant poisoning. American Journal of Emergency Medicine 1999;17:495-496.
- James LP, Stowe CD, Farrar HC, Menendez AA, Argao EA. The pharmacokinetics of oral ranitidine in children and adolescents with cystic fibrosis. Journal of Clinical Pharmacology 1999;39:1242-1247.
- James LP, Wilson JT, Simar R, Farrar HC, Kearns GL, Simpson PM, Hinson JA, Pumford NR. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Clinical Pediatrics 2001;40:243-248.
- James LP, Farrar HC, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Walson PD, Hinson JA, Pumford NR, and the PPRU Network. Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. Journal of Clinical Pharmacology 2001;41:846-851.
- James LP, Farrar HC, Darville TL, Sullivan JE, Givens TG, Kearns GL, Wasserman GS, Simpson PS, Hinson JA and the PPRU Network. Elevation of Serum Interleukin-8 in Acetaminophen Overdose in Children and Adolescents. Clinical Phamacology and Therapeutics 2001;70:280-286.
- James LP, Wells E, Beard RH, Farrar HC. Predictors of Outcome following acetaminophen poisoning in children and adolescents. Journal of Pediatrics 2002;140:522-526.
- Farrar HC, Letzig L, Gill MA. Validation of a liquid chromatographic method for the determination of ibuprofen in human plasma. Journal of Chromatography B. 2002;780:341-348.
- James LP, Simpson PM, Farrar HC, Kearns GL, Wasserman GS, Blumer JL, Reed MD, Sullivan JE, Hinson JA, PPRU Network. Cytokines and toxicity in acetaminophen overdose. Journal of Clinical Pharmacology 2005;45:1-7.
- Sisterhen LL, Stowe CD, Farrar HC, Blaszak CK, Blaszak RT. Disposition of Ceftazidime Following Intraperitoneal Administration in Adolescent Patients Receiving Continuous Cycling Peritoneal Dialysis. American Journal of Kidney Diseases 2006;47:503-508.
- Fussell JJ, Farrar HC, Blaszak RT, Sisterhen LL. Incorporating the ACGME educational competencies into morbidity and mortality review conferences. Teaching and Learning in Medicine 2009;21:233-239.
- Boateng BA, Bass LD, Blaszak RT, Farrar HC. Development of a competency based assessment rubric to measure resident milestones. Journal of Graduate Medical Education 2009;1(1):45-48.
Case Reports
- Farrar HC, Herold D, Reed MD. Acute valproic acid intoxication: enhanced drug clearance with oral activated charcoal. Critical Care Medicine 1993;21:299-301.
- Farrar HC, Walsh-Sukys MC, Kyllonen K, Blumer JL. Cardiac toxicity associated with intravenous erythromycin lactobionate: two case reports and a review of the literature. Pediatric Infectious Disease Journal 1993;12:688-691.
- Marshall JD, Farrar HC, Kearns GL. Diarrhea associated with enteral benzodiazepine solutions. Journal of Pediatrics 1995;126:657-659.
- Christensen C, Farrar HC, Kearns GL. Protracted methemoglobinemia following phenazopyridine overdose in an infant. The Journal of Clinical Pharmacology 1996;36:112-116.
- James LP, Farrar HC, Griebel ML, Bates SR. Bromism: Intoxication from a rare therapy. Pediatric Emergency Care 1997;13:268-270.
- Raknmanina NY, Kearns GL, Farrar HC. Symptomatic hypokalemia in in asthmatic child from abuse of albuterol metered dose inhaler. Pediatric Emergency Care 1998;14:145-147.
- Stowe CD, Bolliger TL, James LP, Haley TM, Griebel ML, Farrar HC. Acute mental status changes and hyperchloremic metabolic acidosis with long-term topiramate therapy. Pharmacotherapy 2000;20:105-109.
- Narsinghani U, Chadha M, Farrar HC, Anand KS. Life threatening respiratory failure following accidental infusion of polyethylene glycol electrolyte solution into the lung. Clinical Toxicology 2001;39:105-107.
Reviews
- Farrar HC, Kearns GL. Cocaine: clinical pharmacology and toxicology. Journal of Pediatrics 1989;115:665-675.
- Farrar HC, Blumer JL. The fetal effects of maternal drug use. Annual Reviews of Pharmacology and Toxicology 1991;31:525-47.
- Farrar HC, Kearns GL. Antimicrobial Pharmacotoxicity; In: Cystic Fibrosis Pulmonary Infections: Lessons from Around the World, A. Bauernfeind, M.I. Marks, B. Strandvik, editors. 1996, Birkhauser Verlag, Basel.
- Farrar HC, Wells TG, Kearns GL. Paediatric clinical pharmacology: reclaiming the therapeutic orphan. Expert Opinion on Investigational Drugs 1996;5:7-13.
- Stowe CD, Farrar HC. Pharmacokinetics of Antimicrobial Agents; In: Priniciples and Practice of Pediatric Infectious Diseases, SS Long, LK Pickering, CG Prober, editors. 1997, Churchill Livingstone, New York.
- Farrar HC, James LP, Schutze GE. Antimicrobial therapy for infections of the central nervous system. Seminars in Pediatric Infections Diseases 1998;9:314-321.
Editorials & Other Publications
- James LP, Abdel-Rahmen S, Farrar HC, Jacobs RF. Antimicrobial Agents; In: Priniciples and Practice of Pediatric Infectious Diseases, 2nd Ed., Long, Pickering & Prober, editors. 2003, Churchill Livingstone, NY.
- Maples HD, Farrar HC. Case Studies Show Principles of Pediatric Therapeutic Drug Monitoring: Part 1. Clinical and Forensic Toxicology News 2003 (December):3-4.
- Maples HD, Farrar HC. Case Studies Show Principles of Pediatric Therapeutic Drug Monitoring: Part 2. Clinical and Forensic Toxicology News 2004 (January):3-5.
- James LP, Farrar HC, Palmer K, Kearns GL. Gastrointestinal Drugs; In: Neonatal & Pediatric Pharmacology, 3rd Ed., SJ Yaffe & JV Aranda, editors. 2005, Lippincott, Williams & Wilkins.
- Sullivan JE, Farrar HC, Section on Clinical Pharmacology and Therapeutics, Committee on Drugs. Clinical Report: Antipyretic Use in Children. Pediatrics (in press)
- Farrar HC, Walsh-Sukys MC, Kyllonen K, Blumer JL. Erythromycin lactobionate toxicity in premature neonates: reply Pediatric Infectious Disease Journal 1994;13:166-167. (Response to Letter)
- Farrar HC. Using therapeutic drug monitoring can improve the cost to benefits for some drugs. Drugs & Therapy Perspectives 1994;4(2):15 (Invited editorial)
- Valentine JL, Farrar HC, James L, Wells T, Simpson P. Urine drug screening. Journal of Clinical Pharmacology 1999;39:425-428. (Letter to the editor)
