SAFETY DATA SHEET

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses: Reagent for development and research

1.3 Details of the supplier of the safety data sheet

Company: Merck Pty Ltd.

259 Davidson Road, Corner Peddie Road
WADEVILLE, GERMISTON
1428
SOUTH AFRICA

Telephone: +27 (0) 8600 63725

Fax: +27 (0) 860 522 329

1.4 Emergency telephone number

Emergency Phone #: 0-800-983-611 (CHEMTREC)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

• Eye irritation, (Category 2) - H319: Causes serious eye irritation.
• Skin sensitisation, (Category 1) - H317: May cause an allergic skin reaction.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008

Pictogram: ⚠️

Signal Word: Warning

Hazard Statements

• H317: May cause an allergic skin reaction.
• H319: Causes serious eye irritation.

Precautionary Statements

• P261: Avoid breathing dust.
• P264: Wash skin thoroughly after handling.
• P272: Contaminated work clothing should not be allowed out of the workplace.
• P280: Wear protective gloves/ eye protection/ face protection.
• P302 + P352: IF ON SKIN: Wash with plenty of water.
• P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Supplemental Hazard Statements: none

Reduced Labelling (<= 125 ml)

Pictogram: ⚠️

Signal Word: Warning

Hazard Statements

• H317: May cause an allergic skin reaction.

Precautionary Statements

• P261: Avoid breathing dust.
• P272: Contaminated work clothing should not be allowed out of the workplace.
• P302 + P352: IF ON SKIN: Wash with plenty of water.

Supplemental Hazard Statements: none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Ecological information:

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

Toxicological information:

The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances

Concentration limits: >= 0,1 %: Skin Sens. 1, ;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures

General advice: Show this safety data sheet to the doctor in attendance.

If inhaled: After inhalation: fresh air.

In case of skin contact: In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact: After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed: After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media: Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides
Hydrogen bromide gas
Sodium oxides
Combustible.

Fire may cause evolution of:

• hydrogen bromide

Vapours are heavier than air and may spread along floors.

Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions: Tightly closed. Dry.

Recommended storage temperature see product label.

Storage class: Storage class (TRGS 510): 11: Combustible Solids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

8.2 Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

• Material: Nitrile rubber
• Minimum layer thickness: 0,11 mm
• Break through time: 480 min
• Material tested:KCL 741 Dermatril® L

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact

• Material: Nitrile rubber
• Minimum layer thickness: 0,11 mm
• Break through time: 480 min
• Material tested:KCL 741 Dermatril® L

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type P2

The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

9.2 Other safety information

Bulk density: ca.710 kg/m3

SECTION 10: Stability and reactivity

10.1 Reactivity

Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions

Violent reactions possible with: Strong oxidizing agents

10.4 Conditions to avoid

Strong heating.

10.5 Incompatible materials

No data available

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

• LD50 Oral - Rat - female - > 2.000 mg/kg (OECD Test Guideline 423)
• Inhalation: No data available
• LD50 Dermal - Rat - female - > 2.000 mg/kg (OECD Test Guideline 402)

Skin corrosion/irritation

• Skin - Rat
• Result: No skin irritation - 24 h (OECD Test Guideline 402)

Serious eye damage/eye irritation

• Eyes - Human
• Result: Causes serious eye irritation. - 6 h (OECD Test Guideline 492)

Respiratory or skin sensitization

• Patch test: - Human
• Result: positive
• Remarks: (ECHA)

Germ cell mutagenicity

• No data available
• Test Type: Ames test
• Test system: Salmonella typhimurium
• Metabolic activation: with and without metabolic activation
• Method: OECD Test Guideline 471
• Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

11.2 Additional Information

Endocrine disrupting properties

Product:

Assessment: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity

• Toxicity to fish: LC50 - Oryzias latipes (Orange-red killifish) - 1.200 mg/l - 48 h Remarks: (ECOTOX Database)
• Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)
• Toxicity to algae: static test ErC50 - Desmodesmus subspicatus (green algae) - 51,3 mg/l - 72 h (OECD Test Guideline 201)
• Toxicity to bacteria: NOEC - Bacteria - 100 mg/l - 250 min Remarks: (ECHA)

12.2 Persistence and degradability

Biodegradability: aerobic - Exposure time 28 d
Result: 94,56 % - Readily biodegradable. (OECD Test Guideline 301D)

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Endocrine disrupting properties

Product:

Assessment: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

No data available

SECTION 14: Transport information

14.6 Special precautions for user

No data available

Further information

Not classified as dangerous in the meaning of transport regulations.

14.7 Maritime transport in bulk according to IMO instruments

Not applicable for product as supplied.

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006.

Authorisations and/or restrictions on use

No data available

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements

• H317: May cause an allergic skin reaction.
• H319: Causes serious eye irritation.

Full text of other abbreviations

ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response; ELx - Loading rate associated with x% response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x% growth rate response; GHS - Globally Harmonised System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organisation; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organisation for Standardisation; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organisation for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

Further information

The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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