NanoDrop One Release Notes

About This Document

This document contains a revision history of Thermo Scientific NanoDrop™ One/One^C PC Software and Thermo Scientific NanoDrop™ One/ One^C Local Control Software, which includes new features, resolved and known issues.

NanoDrop One PC Software v2.3.0

Release Date: Mar 2021

Supported Operating Systems: Windows 10 64-bit

New Features

• Protein & Labels application: Run blank and measurement on pedestal and cuvette, supports Analysis Correction. Protein & Labels experiment data can be viewed in the History page. Ability to customize which columns are displayed in History and in the measurement acquisition screen. Export data in multiple file formats (.tsv and .ned). Support import of .ned/.sql files and PC Viewer database files into History.
• Protein BCA application: A standard curve is required for colorimetric protein analysis and support to import a standard curve. Run blank and measurement on pedestal and cuvette. Protein BCA experiment data can be viewed in the History page. Ability to customize which columns are displayed in History and in the measurement acquisition screen. Export data in multiple file formats (.tsv and .ned). Support import of .ned/.sql files and PC Viewer database files into History.
• Print reports added the units with the concentration column

Resolved Issues

• Negative concentration display: Released applications display the negative concentration value instead of showing ‘NA’.
• Export files: Protein A280 concentration results exported in .tsv files supporting three decimal points.
• Analytical Wavelength in UV-Vis: This version resolved an issue where the analytical wavelength was not worked in UV-Vis application.

Known Issues

None

NanoDrop One Local Control Software v2.3.0

Release Date: Mar 2021

New Features

• Protein & Labels added A260/A280 result of sample details screen

Resolved Issues

• Analytical Wavelength in UV-Vis: This version resolved an issue where the analytical wavelength was not worked in UV-Vis application.

NanoDrop One PC Software v2.2.0

Release Date: Dec 2020

Supported Operating Systems: Windows 10 64-bit

New Features

• RNA/DNA Deconvolution: Improved algorithms for differentiation of mammalian DNA from RNA and vice versa in dsDNA/RNA applications.
• Microarray application: Run, blank, and measurement on pedestal and cuvette, supports Analysis Correction. Microarray experiment data can be viewed in the History page. Ability to customize which columns are displayed in History and in the measurement acquisition screen. Export data in multiple file formats (.tsv and .ned). Support import of .ned/.sql files and PC Viewer database files into History.
• Released application support of exporting .sql instrument files from the PC software
• Add policy in Security Administration: Prevent export of .sql (instrument files) from the PC software.

Resolved Issues

• Print reports: Signature Log did not print out with the Intensity Check and Performance Verification.
• Export files: Cuvette Intensity Check results exported in .tsv format misidentified the sample location.

Known Issues

None

NanoDrop One Local Control Software v2.2.0

Release Date: Dec 2020

New Features

• RNA/DNA Deconvolution: Improved algorithms for differentiation of mammalian DNA from RNA and vice versa in dsDNA/RNA applications.

Resolved Issues

• History icon: The word “Local” in certain languages would cause the History icon to disappear.

NanoDrop One PC Software v2.1.0

Release Date: Oct 2020

Supported Operating Systems: Windows 10 64-bit

New Features

• RNA/DNA Deconvolution: New analyses that differentiate mammalian DNA from RNA and vice versa in dsDNA/RNA applications.
• Oligo DNA/Oligo RNA applications: Run blank and measurement on pedestal and cuvette, supports baseline correction. Oligo DNA/Oligo RNA experiment data can be viewed in the History page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Export data in multiple file formats (.tsv and .ned). Support import of .ned/.sql files and PC viewer database files into History.
• Protein A205 application: Calculate peptide concentration based on user defined factor, run blank and measurement on pedestal and cuvette, supports baseline correction. Protein A205 experiment data can be viewed in the History page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro bubble detection includes a check for blank and measurement integrity. Export data in multiple file formats (.tsv and .ned). Support import of .ned/.sql file and PC viewer database files into History.
• Show monitored wavelength: Show and Print extra monitored wavelength in Nucleic Acids and Protein applications.

Resolved Issues

• Export files: Fixed a formatting issue when exporting .tsv data on French and Danish operation systems.
• PC viewer Custom method: Fixed Custom Method from PC viewer cannot import to NanoDrop One PC software.

Known Issues

None

NanoDrop One Local Control Software v2.1.0

Release Date: Oct 2020

New Features

• RNA/DNA Deconvolution: New analyses that differentiate mammalian DNA from RNA and vice versa in dsDNA/RNA applications.
• Dye Editor wavelength: Wider Dye Editor wavelength update to 350-850nm.

Resolved Issues

• Launcher screen: The version resolves an issue related to the software launch interface.
• Pedestal image sensor is not responding: Added message prompting users to restart the instrument when pedestal image sensor is not responding.

NanoDrop One PC Software v2.0.1

Release Date: Sep 2020

Supported Operating Systems: Windows 10 64-bit

New Features

NA

Resolved Issues

• Intensity Check: This version resolves an issue in how the experiment timestamp was displayed in History.

Known Issues

None

NanoDrop One PC Software v2.0.0

Release Date: July 2020

Supported Operating Systems: Windows 10 64-bit

New Features

• Initial Release of software from which users can control the instrument
• NanoDrop One PC Viewer Software is retired.
• Integrate features required by 21 CFR Part 11 regulations
• Chinese language support

All new Features list as below:

• Nucleic Acid
• dsDNA application: Run blank and measurement on pedestal and cuvette, supports baseline correction. dsDNA experiment data can be viewed in the History detail page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro contaminant analysis/ bubble detection includes a check for blank and measurement. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and PC viewer database files in History.
• ssDNA application: Run blank and measurement on pedestal and cuvette, supports baseline correction. ssDNA experiment data can be viewed in the History detail page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro includes a bubble detection check for blank and measurement. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and PC viewer database files in History.
• RNA application: Run blank and measurement on pedestal and cuvette, supports baseline correction. RNA experiment data can be viewed in the History detail page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro contaminant analysis/ bubble detection includes a check for blank and measurement. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and PC viewer database files in History.
• Custom Factor application: Calculate nucleic acid concentration based on user defined factor. Run blank and measurement on pedestal and cuvette, supports baseline correction. Custom factor experiment data can be viewed in the History detail page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro includes a bubble detection check for blank and measurement. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and PC viewer database files in History.
• Protein
• Protein Editor: User-entered protein extinction coefficients in the Protein Editor can be selected from the Protein A280 drop-down menu.
• Protein A280: Calculate protein concentration based on user defined factor, run blank and measurement on pedestal and cuvette, supports baseline correction. Protein A280 experiment data can be viewed in the History detail page. Ability to customize what columns are displayed in History and in the measurement acquisition screen. Acclaro contaminant analysis/ bubble detection includes a check for blank and measurement. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and PC viewer database files in History.
• Custom
• Custom Methods: Formula and standard curve custom methods can be created in the Custom method application. Run blank and measurement on pedestal and cuvette, supports analysis wavelength and quantification step. Export data in multiple file formats (.tsv and .ned). Support to import .ned/.sql file and NanoDrop One PC viewer database file in History.
• UV-Vis: The UV-Vis application allows the NanoDrop One/NanoDrop One PC to function as a conventional spectrophotometer. Wavelengths can be entered for absorbance monitoring and inclusion in the results. Sample absorbance is displayed on the screen from 190nm to 840nm.
• Diagnostics
• Performance Verification: Users enter the target absorbance value on the PV-1 ampoule in the Performance Verification setup page, then blank and measure aliquots of the standard. Pass or fail instructions show at the top of the screen. Experiment data can be viewed in the history detail page. Export data in multiple file formats (. tsv and. ned). Support to import .ned/ .sql file and PC viewer database files in History.
• Intensity Check: Run an Intensity Check through the pedestal or cuvette light paths. Pass or fail instructions show at the top. Experiment data can be viewed in the History detail page. Export data in multiple file formats (. tsv and. ned). Support to import . ned/ sql file and PC viewer database files in History.
• Pedestal Image Check: Run a Pedestal Image Check. Supports Image optimization. Pass or fail instructions show at the top. Experiment data can be viewed in the History detail page. Export data in multiple file formats (. tsv and. ned). Support to import .ned/ .sql file and PC viewer database files in History.
• IQ/OQ: Qualification procedures are now available for the NanoDrop One PC Control software.
• Security with 21CFR part 11 compliance Support: NanoDrop One Security software, together with Thermo Security Administration software, lets the system administrator set system policies and control user access to NanoDrop One software feature. Supports access control, system policies, and signature meanings.

NanoDrop One Local Control Software v2.0.0

Release Date: July 2020

New Features

• NanoDrop One instrument directly connects to the NanoDrop One PC Control software with an Ethernet cable. Instrument can be controlled from the PC and all data are stored on the computer.
• Change "Data Viewer" to "History"

Resolved Issues

None

NanoDrop One Local Control Software v1.4.5

Release Date: February 2020

Resolved Issues

• Fixed issue with running manufacturing and service utilities: NanoDrop One Local Control Software is updated to be compatible with manufacturing and service utilities.

NanoDrop One Local Control Software v1.4.4

Release Date: November 2019

Resolved Issues

• California SB-327 Compliance: NanoDrop One Local Control Software is updated to comply with California SB-327: unique password on each instrument to turn off kiosk mode.

NanoDrop One Local Control Software v1.4.3

Release Date: October 2019

Resolved Issues

• Customer Special Software: NanoDrop One Local Control Software and PC Data Viewer are updated to support two customer special orders.

NanoDrop One Local Control Software v1.4.2

Release Date: November 2017

Resolved Issues

• Blue Screen Lockup: Some NanoDrop One/NanoDrop One instruments experienced a lockup where the instrument software did not get past the blue droplet screen. This version fixes this issue. It is recommended that all users upgrade to this version of the local control software.

NanoDrop One Local Control Software v1.4

Release Date: May 2017

New Features

• Wi-Fi and Ethernet Networking and Export: Users can connect the NanoDrop One/NanoDrop One^C to a Wi-Fi network by selecting System →Networking→Wi-Fi. Users can select System→Networking→Ethernet to connect to a wired network or directly to a PC. A list of network locations can be pre-defined under the System→Export tab. This list is presented when the user selects Export in the End Experiment dialog or in the Data Viewer.
• Cloud Connect: The NanoDrop One/NanoDrop One^C can now connect to the Thermo Fisher Cloud and export data to the user's cloud account. The exported data may be viewed or manipulated using the NanoDrop Cloud application. Users can setup their account details on the Settings → Network tab. Once an account is setup, a new option "Thermo Fisher Cloud” is added to the Export dropdown. When “Thermo Fisher Cloud” is selected as the export location, a user account list is presented. Data can be exported by selecting the appropriate user account name.
• Wi-Fi/USB Printing: All NanoDrop One/NanoDrop One^C instruments with v1.4 of Local Control Software can print reports to a standard USB or Wi-Fi connected printer. To configure a printer for the first time, select the Print option from the main menu when in an experiment and follow the instructions. If you have upgraded the NanoDrop One/NanoDrop One^C Local Control Software from an earlier version to v1.4, your NanoDrop One/NanoDrop One^C instrument will need to be connected to the Internet over Wi-Fi or Ethernet. Once connected, select the Print option from the main menu of an experiment and follow the instructions. When a Dymo printer is connected, the instrument will honor the Dymo printer exclusively. In order to use regular printer, the Dymo printer needs to be disconnected.
• Note: A variety of printer manufacturers and models are supported. Many printers from the same printer manufacturer behave the same way. If your printer model is not found in the list, try selecting the closest printer model and test it.
• 16GB Data Storage: Data storage limit on the NanoDrop One/NanoDrop One^C is extended to 16GB. This extended memory will also be available to NanoDrop One/NanoDrop One^C instruments upgrading to v1.4.
• Export Logs: Users can export logs to an USB flash drive by selecting Diagnostics → Export Logs option. Logs can only be exported to a connected USB flash drive.
• "All" Option in Search Time Range: It is now possible to search all the experiments by selecting the “All” option in the Search Dialog's time range dropdown.
• Edit Experiment Name: In Experiment Details dialog the experiment name field is editable and the experiment name can be changed and saved.
• Export .sql files for individual experiments: Users can now export .sql files for individual experiments, rather than a single .sql file for all experiments.

Resolved Issues

• Custom Method Issues: This version resolves an issue where the entered wavelength was not used during analysis.
• Protein Bradford: When saving standards under the Protein Bradford method, all numbers after the decimal are now included.

Known Issues

None

NanoDrop One PC Viewer Software v1.4

Release Date: May 2017

Supported Operating Systems: Windows 7 32-Bit, Windows 7 64-bit, Windows 10

New Features

• Edit Experiment Name: In Experiment Details dialog the experiment name field is editable and the experiment name can be changed and saved.

Resolved Issues

• Printing Intensity Check: An issue where the Xe monitored peaks were printed incorrectly when printing an Intensity Check experiment is now resolved.
• Exporting to .tsv Format: Fixed an issue where an incorrect delimiter was used when exporting in .TSV format has now been resolved.

Known Issues

None

NanoDrop One Local Control Software v1.3 Hot Fix 1

Release Date: November 2016

Supported Operating Systems: NanoDrop One Instrument Android OS

New Features

• Export for Cloud: A new feature has been added to Export to export the currently selected experiment to Cloud format to read into the NanoDrop Cloud application.

Resolved Issues

None

Known Issues

None

NanoDrop One Local Control Software v1.3

Release Date: September 2016

Supported Operating Systems: NanoDrop One Instrument Android OS

New Features

• Translations: Software and Help: Software and Help translations are available in the following languages: Chinese, Japanese, Polish, Korean, German, French, Spanish. The instrument is delivered with English software and Help. Language packs can be downloaded from our website: www.thermoscientific.com/nanodrop

Resolved Issues

• Blank PC Name: PC Name in PC Viewer cannot be blank to connect to Wi-Fi, if it is blank the instrument will recognize that it is connected to a PC via Wi-Fi but it will not be available in the drop down menu.
• Kinetics Interval Error Message: A dialog was displayed in error indicating that the kinetics interval was less than two seconds when the interval was acceptable.
• GuSCN or GUHCI contamination: When a sample is contaminated with GuSCN or GUHCl the Acclaro results displayed the incorrect result under the contaminate row-A260 column. This issue has been fixed.
• Execution of Custom Methods: Custom methods failed to run correctly, this issue has been fixed.

Known Issues

None

NanoDrop One PC Viewer Software v1.3

Release Date: September 2016

Supported Operating Systems: Windows 7 32-Bit, Windows 7 64-bit, Windows 10

New Features

• Translations: Software and Help: Software and Help translations are available in the following languages: Chinese, Japanese, Polish, Korean, German, French, Spanish. The instrument is delivered with English software and Help. Language packs can be downloaded from our website: www.thermoscientific.com/nanodrop

Resolved Issues

• Display Issues: When Overlay mode has been turned off, there were some issues with selection of sample. These issues have been fixed.
• Y-axis Label for Blank: The Y-axis label for blank measurements in the PC Data Viewer software was displaying 10mm Absorbance. This is incorrect and has been fixed.

Known Issues

None

NanoDrop One Local Control Software v1.2

Release Date: February 2016

Supported Operating Systems: Windows 7 32-Bit, Windows 7 64-bit, Windows 10

New Features

• UV-Vis Application: The UV-Vis application allows the NanoDrop One/NanoDrop One^C to function as a conventional spectrophotometer. Up to 40 wavelengths can be selected for absorbance monitoring and inclusion in the final results. Sample absorbance is displayed on the screen from 190nm to 840nm. UV-Vis experiment data can be viewed in the PC Viewer software.
• Kinetics Application: The NanoDrop One^C can be used to make time-based kinetic measurements. Setting up kinetics experiments is easy to do and a visual display shows the stage information such as delay, measurement intervals and stage duration. Up to 5 stages can be created and up to 3 wavelengths can be monitored during the experiment. The user also has the option to Pause or Stop the kinetics experiment. Kinetics data can be displayed as Time vs ABS or Time vs Delta ABS. Kinetics data can also be viewed in the NanoDrop One PC Viewer software.
• Help System Translation: Translation for the help system and Acclaro is now included in the following languages; Chinese, French, German, Japanese, Korean, Polish and Spanish.
• IQ/OQ: Qualification procedures are now available for the NanoDrop One and NanoDrop One^C. New part numbers have been released for full qualification kits in both US binder size and A4 binder size.
• Additional Custom Methods: New custom method options are now available in the NanoDrop One PC Viewer software. These methods are easily created on the PC and executed on the NanoDrop One system. Standard curve custom method options are now available along with the formula and equation types that were available in an earlier version.

NanoDrop One PC Viewer Software v1.2

Release Date: February 2016

Supported Operating Systems: Windows 7 32-Bit, Windows 7 64-bit, Windows 10

New Features

• Wi-Fi Data Transfer: WiFi is now possible using version 1.2 NanoDrop One PC Viewer software. Data can be seamlessly transferred from the NanoDrop One instrument to any WiFi connected PC. All data will be saved on the attached PC rather than on the local control instrument. Data can then be easily viewed using this software during the acquisition and after the experiment has completed.
• Additional Custom Method: New custom method options are now available in the NanoDrop One PC Viewer software. These methods are easily created on the PC and executed on the NanoDrop One system. Standard curve custom method options are now available along with the formula and equation types that were available in an earlier version.
• Export .sql File Format: The database can now be exported from the NanoDrop One PC Viewer software. This was previously only an option from the local control but now it is available from the PC software as well.

Resolved Issues

None

Known Issues

None

NanoDrop One Local Control Software v1.1

Release Date: December 2015

Supported Operating Systems: NanoDrop One Instrument Android OS

New Features

• Direct Connect (PC Tethering): Ethernet direct connect is now possible using version 1.1 NanoDrop One software. Data can be seamlessly transferred from the NanoDrop One instrument to an Ethernet direct connected PC. All data will be saved on the attached PC rather than on the local control system when this options is selected. Data can be viewed from the NanoDrop One PC Viewer software.
• Pedestal Image Check: Enhancements have been completed for the Pedestal Image Check diagnostic. Additional pass/fail information is now displayed along with more detailed information about any issues that may be encountered.
• Software Translation: Translation for the local control software is now included in the following languages; Chinese, French, German, Japanese, Korean, Polish and Spanish.

Resolved Issues

None

Known Issues

None

NanoDrop One PC Viewer Software v1.1

Release Date: December 2015

Supported Operating Systems: Windows 7 32-Bit, Windows 7 64-bit, Windows 10

New Features

• Direct Connect (PC Tethering): Ethernet direct connect is now possible using version 1.1 NanoDrop One software. Data can be seamlessly transferred from the NanoDrop One instrument to an Ethernet direct connected PC. All data will be saved on the attached PC rather than on the local control system when this options is selected. Data can be viewed from the NanoDrop One PC Viewer software.

Resolved Issues

None

Known Issues

None

NanoDrop One Local Control Software v1.0

Release Date: November 2015

Supported Operating Systems: NanoDrop One Instrument Android OS

New Features

Initial Release, all features are new

Resolved Issues

Initial release, there are no resolved Issues

Known Issues

None

NanoDrop One PC Viewer Software v1.0

Release Date: November 2015

Supported Operating Systems: Windows 7 32bit, Windows 7 64bit, Windows 10

New Features

Initial Release, all features are new

Resolved Issues

Initial release, there are no resolved Issues

Known Issues

None

How to Contact Us

Current contact information is located at www.thermofisher.com. Select the "Contact Us" icon at the top of the screen.

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