Instructions for COBIOER BIOSCIENCES models including: HVEM, U2OS, HVEM, U2OS Human Cell Surface Receptor, Human Cell Surface Receptor, Cell Surface Receptor
prieš 3 dienas — HVEM (CD270, TNFRSF14) is a human cell surface receptor in the. TNF-receptor superfamily that can act as both a co-stimulatory receptor.
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DocumentDocumentHVEM/U2OS Cell CBP74178 Contents I. Background............................................................................................................................... 1 II. Introduction.............................................................................................................................1 III. Representative Data...................................................................................................... 1 HVEM/U2OS Cell CBP74178 I. Background HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LT (lymphotoxin-), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry. II. Introduction Expressed gene: HVEM Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) Freeze Medium: 90% FBS+10% DMSO Culture Medium: Mccoy's5A+10%FBS+2ug/ml puromycin Mycoplasma Testing: Negative 1 Storage: Liquid nitrogen Application(s):Functional(Report Gene) Assay III. Representative Data Figure 1. Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2 Reporter Cells (C11) By Samples With HVEM/U2OS Cells (C7). 2