Nerivio Migraine Relief Device

Product Overview

Nerivio is a wireless remote electrical neuromodulation device designed for the acute and preventive treatment of migraine. This prescription device is self-applied to the upper-arm, offering a medicine-free approach to migraine management. It is recommended by leading Neurologists in India.

Each Nerivio device provides 18 treatment sessions, with each session lasting 45 minutes. The device is controlled via the Nerivio smartphone application, allowing users to adjust intensity and track their migraine episodes.

Nerivio is suitable for dual use, providing both acute relief at the onset of a migraine and preventive care when used regularly. Its portable, discrete, and non-invasive design makes it a convenient solution for migraine sufferers.

Image: The Nerivio device shown alongside a smartphone displaying the control application, indicating an active treatment session and intensity settings.

Key Features

• Migraine Relief without Medication: Utilizes clinically proven Remote Electrical Neuromodulation technology that activates Natural Pain Relief Mechanism via Arm to Brain Stimulation.
• Indication for Use: For acute and/or preventive treatment of migraine.
• Preventive Treatment Usage: Use every other day for at least 3 months to experience in Migraine Headache days.
• Acute Treatment Usage: At the onset of migraine headache or aura.
• Optimal for Adults and Teens: Designed for safe and effective use across a broad age range.

Setup Guide

Before using your Nerivio device, please follow these steps for proper setup:

1. Charge the Device: Ensure your Nerivio device is fully charged before first use. Refer to the charging indicator on the device or within the app.
2. Download the Nerivio App: Install the official Nerivio application on your smartphone. The app is available for both iOS and Android devices.
3. Pair the Device: Open the Nerivio app and follow the on-screen instructions to pair your device via Bluetooth. Ensure Bluetooth is enabled on your smartphone.
4. Create Your Profile: Complete your user profile within the app, which may include information relevant for tracking your migraine patterns.

Image: Visual guide illustrating the three main steps for using Nerivio: wearing the device on the arm, connecting via the app, and relaxing during treatment.

Operating Instructions

Using your Nerivio device for migraine treatment is straightforward. Follow these steps for each session:

1. Prepare Your Skin: Ensure the skin on your upper arm where the device will be placed is clean and dry.
2. Place the Device: Securely attach the Nerivio device to your upper arm using the provided strap. Ensure the electrodes make good contact with your skin.
3. Start Treatment via App: Open the Nerivio app on your smartphone. Select the desired treatment type (acute or preventive) and initiate the session.
4. Adjust Intensity: Slowly increase the intensity of the stimulation through the app until you feel a strong but comfortable sensation. Do not increase to a painful level.
5. Session Duration: Each treatment session lasts for 45 minutes. The app will provide a countdown and notify you when the session is complete.
6. Remove Device: Once the session is finished, turn off the device via the app and carefully remove it from your arm.

Treatment Protocols

• Acute Treatment: Use for 45 minutes at the onset of a migraine headache or aura, ideally within 60 minutes of pain onset.
• Preventive Treatment: Perform a Nerivio treatment every alternate day for at least 3 months to experience a reduction in migraine headache days.

Mechanism of Action

The Nerivio device employs Remote Electrical Neuromodulation (REN) technology to provide migraine relief. This mechanism involves a sophisticated interaction with the body's natural pain pathways:

• Neuromodulation: The device acts via neuromodulation, stimulating Aδ & C fibres in the upper arm.
• Strengthens CPM: This stimulation strengthens the Conditioned Pain Modulation (CPM) system through activation of descending pain pathways.
• Neurotransmitter Release: It facilitates the release of serotonin and norepinephrine in the Periaqueductal Gray (PAG) and Rostral Ventromedial Medulla (RVM), which are crucial brain regions involved in pain processing.
• Pain Signal Blocking: By releasing these neurotransmitters, Nerivio effectively blocks pain signals to the cortex, thereby aborting migraine pain.

Image: A detailed diagram showing how the Nerivio device stimulates nerve fibers in the arm, sending signals to the brain to activate pain modulation systems and reduce migraine pain.

Benefits of Nerivio

Nerivio offers several significant benefits for individuals seeking migraine relief:

• Clinically Proven: Backed by clinical studies demonstrating its effectiveness in treating and preventing migraines.
• Drug-Free: Provides relief without the need for medication, reducing concerns about side effects or drug interactions.
• Non-Invasive: Applied externally to the arm, avoiding any invasive procedures.
• Smartphone-Controlled: Easy to manage and customize treatment sessions via a user-friendly mobile application.
• Portable and Discrete: Its compact design allows for convenient use at home or on the go.
• Reduced Migraine Days: Regular preventive use can lead to a significant reduction in the frequency of migraine headache days.

Image: An infographic highlighting the various benefits of using Nerivio, such as being clinically proven, drug-free, non-invasive, and smartphone-controlled.

Image: A visual representation of a patient experiencing relief, emphasizing that 66.4% of patients reported relief from migraine symptoms within 2 hours.

Care and Maintenance

Proper care and maintenance will ensure the longevity and optimal performance of your Nerivio device:

• Cleaning: After each use, gently wipe the device, especially the electrode area, with a soft, damp cloth. Do not use abrasive cleaners or immerse the device in water.
• Storage: Store the device in a cool, dry place away from direct sunlight and extreme temperatures. Keep it in its original packaging or a protective case when not in use.
• Battery Care: Recharge the device regularly, even if not in frequent use, to maintain battery health. Avoid completely draining the battery for extended periods.
• Electrode Pads: Ensure the electrode pads are clean and free from debris. Replace them as recommended by the manufacturer if they show signs of wear or reduced adhesion.

Troubleshooting

If you encounter any issues with your Nerivio device, please refer to the following common troubleshooting tips:

If the problem persists after trying these solutions, please contact customer support for further assistance.

Product Specifications

Important Information

Please read the following important information carefully before using the Nerivio device:

Legal Disclaimer:

Manufacture, Expiry dates and other information are mentioned on the products. Please always read labels and warnings before using or consuming the product.

This device is a prescription device. Consult with your healthcare provider to determine if Nerivio is appropriate for your condition.

Warranty and Support

For any questions, technical support, or warranty inquiries regarding your Nerivio device, please contact the manufacturer or authorized distributor.

• Manufacturer: Dr. Reddy's Laboratories Ltd (Packer/Importer listed)
• Model: Theranica Bio-Electronics LTD.
• Refer to the product packaging or the official Nerivio website for specific contact details and warranty terms.