1. Introduction
This manual provides essential information for the safe and efficient use of your Lenovo ThinkCentre M75s Gen 2 11R8004GUS Desktop Computer. Please read this manual thoroughly before operating your device and retain it for future reference. This small form factor desktop is equipped with an AMD Ryzen 7 PRO 5750G processor, 16GB DDR4 RAM, a 512GB SSD, and runs on Windows 11 Pro.
2. Safety Information
Observe the following safety precautions to prevent damage to your computer and to ensure your personal safety:
- Always disconnect the power cord from the electrical outlet before cleaning or servicing the computer.
- Do not expose the computer to rain or moisture.
- Avoid placing the computer near heat sources or in direct sunlight.
- Ensure proper ventilation; do not block any ventilation openings.
- Use only the power adapter supplied with your computer.
- Do not attempt to repair the computer yourself. Refer all servicing to qualified personnel.
3. Package Contents
Verify that all items are present in your product package:
- Lenovo ThinkCentre M75s Gen 2 Desktop Computer
- USB Traditional Keyboard
- USB Calliope Mouse
- Vertical Stand
- Power Adapter
4. Component Overview
Familiarize yourself with the various components and ports of your ThinkCentre M75s Gen 2 desktop.

Figure 4.1: Angled front-left view of the Lenovo ThinkCentre M75s Gen 2 desktop computer. This view highlights the compact design and the front panel layout.

Figure 4.2: Front view of the Lenovo ThinkCentre M75s Gen 2 desktop. The front panel includes the power button, optical drive, USB ports, and audio jacks for convenient access.
4.1 Front Panel
- Power Button: Used to turn the computer on or off.
- Optical Drive (DVD-Writer): For reading and writing CDs and DVDs.
- USB Ports: Multiple USB ports for connecting peripherals like keyboards, mice, and external storage devices.
- Audio Jacks: Headphone and microphone ports.

Figure 4.3: Rear view of the Lenovo ThinkCentre M75s Gen 2 desktop, showing the various connectivity options for monitors, network, and additional USB devices.
4.2 Rear Panel
- Display Ports: Includes DisplayPort and VGA for connecting monitors.
- USB Ports: Additional USB ports for various devices.
- Ethernet Port: For wired network connection (Gigabit Ethernet).
- Power Connector: For connecting the power adapter.
5. Setup
Follow these steps to set up your Lenovo ThinkCentre M75s Gen 2 desktop computer:
- Position the Computer: Place the desktop on a stable, flat surface. Ensure adequate ventilation around the computer. You may use the included vertical stand for upright positioning.
- Connect Peripherals:
- Connect the USB keyboard and mouse to any available USB ports on the front or rear panel.
- Connect your monitor(s) to the DisplayPort or VGA ports on the rear panel.
- If using a wired network, connect an Ethernet cable to the Ethernet port on the rear panel.
- Connect Power: Connect the power adapter to the power connector on the rear of the computer, then plug the power adapter into a grounded electrical outlet.
- Power On: Press the power button on the front panel of the computer. The system will boot up, and Windows 11 Pro will begin its initial setup process if it's the first time powering on.

Figure 5.1: Example setup of the ThinkCentre M75s Gen 2 with a single monitor, keyboard, and mouse connected.
6. Operating Instructions
6.1 Initial Windows 11 Pro Setup
Upon first boot, follow the on-screen prompts to complete the Windows 11 Pro setup, which includes setting up your region, language, network connection, and user account.
6.2 Basic Operation
- Power On/Off: Press the power button to turn on. To shut down, click the Start button in Windows, then Power > Shut down.
- Restart: From the Start menu, select Power > Restart.
- Sleep Mode: From the Start menu, select Power > Sleep.
- Using the Optical Drive: Insert a CD or DVD into the optical drive. Windows will typically auto-detect the disc and prompt for action.
- Connecting to the Internet: If using a wired connection, ensure the Ethernet cable is securely connected. Windows 11 Pro will automatically detect the network.
7. Maintenance
Regular maintenance helps ensure the longevity and optimal performance of your computer.
- Cleaning: Use a soft, dry cloth to clean the exterior of the computer. For the screen, use a specialized screen cleaner and a microfiber cloth. Avoid liquid cleaners directly on components.
- Software Updates: Regularly check for and install Windows updates and driver updates to ensure system stability and security. Go to Settings > Windows Update.
- Data Backup: Periodically back up important data to an external drive or cloud storage to prevent data loss.
- Ventilation: Ensure that the ventilation openings are not obstructed to prevent overheating.
8. Troubleshooting
This section addresses common issues you might encounter. For more complex problems, refer to Lenovo's official support resources.
8.1 No Power
- Ensure the power cord is securely connected to both the computer and the electrical outlet.
- Verify the electrical outlet is functional by plugging in another device.
- Check the power adapter for any visible damage.
8.2 No Display on Monitor
- Confirm the monitor is powered on and connected correctly to the computer's DisplayPort or VGA port.
- Try connecting the monitor to a different display port if available, or test with another monitor.
- Ensure the correct input source is selected on your monitor.
8.3 Slow Performance
- Close unnecessary applications running in the background.
- Check for and install any pending Windows updates.
- Run a disk cleanup and defragmentation (for HDDs, not typically needed for SSDs).
- Scan for malware or viruses.
9. Specifications
| Feature | Detail |
|---|---|
| Model | Lenovo ThinkCentre M75s Gen 2 (11R8004GUS) |
| Processor | AMD Ryzen 7 PRO 5750G (3.8 GHz) |
| RAM | 16 GB DDR4 |
| Storage | 512 GB SSD |
| Graphics | AMD Radeon Graphics (Integrated) |
| Operating System | Windows 11 Pro |
| Optical Drive | DVD-Writer |
| Connectivity | Gigabit Ethernet |
| Ports | USB 2.0 (4), other USB ports, DisplayPort, VGA, Audio Jacks |
| Dimensions (LxWxH) | 21 x 15.5 x 7.8 inches |
| Weight | 11.68 pounds |
10. Warranty and Support
Your Lenovo ThinkCentre M75s Gen 2 desktop computer comes with a standard manufacturer's warranty. For specific warranty terms and conditions, please refer to the warranty documentation included with your product or visit the official Lenovo support website.
For technical assistance, driver downloads, or further troubleshooting, please visit the Lenovo Support website:
When contacting support, please have your model number (11R8004GUS) and serial number ready.