1. Introduction
The MOXA NPort 6650-16 is a 16-port rackmount RS-232/422/485 secure device server designed for connecting serial devices to an Ethernet network. It provides robust and secure data transmission, enabling remote access and management of serial equipment over IP networks. This manual provides essential information for the proper setup, operation, maintenance, and troubleshooting of your NPort 6650-16 device server.
2. Setup
2.1 Unpacking and Inspection
Before proceeding with installation, carefully unpack the NPort 6650-16 and verify that all components are present and undamaged. The package should typically include:
- MOXA NPort 6650-16 Secure Device Server unit
- Power cord (100V~240VAC input)
- Rackmount kit
- Documentation (Quick Installation Guide, Warranty Card)
If any items are missing or damaged, contact your vendor immediately.
2.2 Hardware Description
The NPort 6650-16 features a modular design with various ports and indicators for easy monitoring and connectivity.

Figure 1: Front and rear view of the MOXA NPort 6650-16 Secure Device Server. The top unit shows the front panel with MOXA branding, status LEDs (PWR, Ready, Link, Alarm), a Reset button, and an SD card slot. The bottom unit shows the rear panel with DC power input (88-300V), a Network Module slot, DOUT, two LAN ports, a Console port, and 16 serial ports (numbered 17-32 on the top row, and 1-16 on the bottom row).
2.2.1 Front Panel
- LED Indicators: PWR (Power), Ready, Link, Alarm. These LEDs provide visual status of the device's operation.
- Reset Button: Used to reset the device to factory defaults or reboot.
- SD Card Slot: For storage or configuration backup.
- Serial Port LEDs: Individual LEDs for each of the 16 serial ports, indicating 'In Use', 'Tx' (Transmit), and 'Rx' (Receive) activity.
2.2.2 Rear Panel
- DC Power Input (88-300V): Terminal block for connecting the DC power supply.
- Network Module Slot: For optional network modules, supporting features like Ethernet redundancy.
- DOUT: Digital Output terminal.
- LAN Ports: Two Ethernet ports for network connectivity.
- Console Port: RJ45 port for local management and configuration via a terminal emulator.
- Serial Ports (16 ports): RJ45 ports for connecting RS-232/422/485 serial devices.
2.3 Installation
2.3.1 Rackmount Installation
Attach the provided rackmount brackets to the sides of the NPort 6650-16 unit using the screws. Secure the unit into a standard 19-inch equipment rack. Ensure adequate ventilation around the device.
2.3.2 Power Connection
Connect the provided power cord to the DC power input terminal block on the rear panel. Ensure the power source is within the specified 100V~240VAC range. Secure the power cable to prevent accidental disconnection.
2.3.3 Network Connection
Connect an Ethernet cable from your network switch or router to one of the LAN ports on the rear panel of the NPort 6650-16. The Link LED on the front panel should illuminate to indicate a successful connection.
2.3.4 Serial Device Connection
Connect your RS-232/422/485 serial devices to the serial ports on the rear panel using appropriate cables. Refer to the device's documentation for pin assignments if custom cabling is required.
2.4 Initial Configuration
After physical installation, the device server requires initial network configuration. This can typically be done via the Console port using a terminal emulator or by discovering the device on the network using MOXA's utility software. Assign a static IP address, subnet mask, and gateway appropriate for your network environment.
3. Operating
3.1 Power On and Status Check
Once power is connected, the PWR LED on the front panel should light up. The Ready LED will indicate when the device server has completed its boot sequence and is operational. Observe the Link LEDs for network connectivity and the serial port LEDs for data activity.
3.2 Network Configuration
Access the device server's web-based management interface or console interface to configure network parameters. This includes setting the IP address, subnet mask, default gateway, and DNS servers. Ensure these settings are compatible with your existing network infrastructure.
3.3 Serial Port Configuration
Each of the 16 serial ports can be individually configured. Key parameters include:
- Baud Rate: Data transmission speed (e.g., 9600, 115200 bps). Nonstandard baudrates are supported with high precision.
- Data Bits: Number of data bits (e.g., 7, 8).
- Parity: Error checking method (None, Odd, Even, Mark, Space).
- Stop Bits: Number of stop bits (e.g., 1, 2).
- Flow Control: Hardware (RTS/CTS) or Software (XON/XOFF) flow control.
- Operating Mode: TCP Server, TCP Client, UDP, Pair Connection, Real COM mode, etc.
3.4 Security Features
The NPort 6650-16 incorporates advanced security features to protect data transmissions. These include DES/3DES/AES encryption for secure communication. The device also adheres to security features based on IEC 62443 standards, ensuring robust industrial cybersecurity.
3.5 Data Transmission and Port Buffers
The device server facilitates seamless data transmission between connected serial devices and the Ethernet network. It includes port buffers for storing serial data when the Ethernet connection is temporarily offline, preventing data loss during network interruptions.
4. Maintenance
4.1 Firmware Updates
Periodically check the MOXA website for firmware updates. Firmware updates can provide new features, performance improvements, and security enhancements. Follow the instructions provided with the firmware package for a safe update process.
4.2 Cleaning
Ensure the device server is powered off and disconnected from all power sources before cleaning. Use a soft, dry cloth to wipe the exterior of the unit. Do not use liquid or aerosol cleaners, as they may damage the device.
4.3 Environmental Considerations
Maintain the operating environment within the specified temperature and humidity ranges to ensure optimal performance and longevity of the device. Avoid exposing the unit to excessive dust, moisture, or direct sunlight.
5. Troubleshooting
5.1 Common Issues and Solutions
- No Power (PWR LED off): Check the power cable connection and the power source. Ensure the input voltage is within the 100V~240VAC range.
- No Network Connectivity (Link LED off): Verify the Ethernet cable connection to the network switch/router. Check network settings (IP address, subnet mask, gateway).
- Serial Communication Problems: Confirm serial port settings (baud rate, data bits, parity, stop bits, flow control) match the connected serial device. Check serial cable integrity and pinout.
- Device Not Responding: Try rebooting the device server. If the issue persists, perform a factory reset using the Reset button (refer to the Quick Installation Guide for specific steps).
5.2 LED Indicator Meanings
| LED | Status | Description |
|---|---|---|
| PWR | On | Device is powered on. |
| Ready | On | Device has completed boot-up and is ready for operation. |
| Link | On | Ethernet link is established. |
| Alarm | On/Flashing | Indicates a system error or warning. Refer to logs for details. |
| Serial Port (In Use) | On | Serial port is actively connected or in use. |
| Serial Port (Tx) | Flashing | Data is being transmitted from the serial port. |
| Serial Port (Rx) | Flashing | Data is being received by the serial port. |
6. Specifications
| Feature | Description |
|---|---|
| Model | NPort 6650-16 |
| Ports | 16 x RS-232/422/485 Serial Ports |
| Input Voltage | 100V~240VAC (via power cord) / DC(88-300V) (via terminal block) |
| Baud Rate Support | Nonstandard baudrates supported with high precision |
| Data Buffering | Port buffers for storing serial data when the Ethernet is offline |
| Network Redundancy | Supports IPv6 / Ethernet redundancy (STP/RSTP/Turbo Ring) with network module |
| Design | Modular design for scalability |
| Security | DES/3DES/AES for highly secure data transmissions, Security features based on IEC 62443 |
| Package Dimensions | 21 x 12 x 5 inches |
| Item Weight | 8.28 pounds |
| Manufacturer | Moxa Inc. |
| Date First Available | February 9, 2018 |
7. Warranty and Support
7.1 Warranty Information
Warranty terms and conditions for the MOXA NPort 6650-16 are typically provided with the product packaging or can be found on the official Moxa website. Please retain your proof of purchase for warranty claims.
7.2 Technical Support
For technical assistance, troubleshooting, or further inquiries regarding the MOXA NPort 6650-16, please visit the official Moxa support website or contact their customer service department. Online resources often include FAQs, driver downloads, and additional documentation.





