Introduction
The M-Audio Oxygen 49 IV is a versatile 49-key USB/MIDI keyboard controller designed for music production and performance. It offers comprehensive control over your software with an array of assignable knobs, pads, and a fader, minimizing the need to interact with your computer mouse. This manual provides essential information for setting up, operating, and maintaining your Oxygen 49 IV.
Setup
System Requirements
- Macintosh: 1.25 GHz G4/G5 or faster (Intel Mac recommended), 1 GB RAM (2 GB recommended), Mac OS X 10.4.11 (10.5 or later recommended).
- Windows: 1.5 GHz Pentium 4 or Celeron compatible CPU or faster (multicore CPU recommended), 1 GB RAM (2 GB recommended), Windows 10, Windows 8, Windows 7, Windows Vista or Windows XP, Windows compatible sound card (ASIO driver support recommended), QuickTime recommended.
- Connectivity: Available USB Port.
Connecting Your Oxygen 49 IV
The Oxygen 49 IV is a class-compliant, plug-and-play device, meaning no special drivers are typically required for basic functionality on supported operating systems. Simply connect the keyboard to an available USB port on your computer using a standard USB A/B cable.

Figure 1: Rear view of the Oxygen 49 IV, highlighting the USB port for connection.
The unit is USB powered, eliminating the need for an external power adapter when connected to a computer.
Initial Software Configuration
For optimal integration with your Digital Audio Workstation (DAW), the Oxygen 49 IV features innovative DirectLink technology. This automatically maps controls to popular DAWs such as Ableton Live, Pro Tools, Logic, and Cubase, providing immediate hands-on control without extensive manual configuration. Refer to your DAW's documentation for specific setup instructions if DirectLink does not automatically configure the device.

Figure 2: The Oxygen 49 IV seamlessly integrated with Pro Tools First software, demonstrating its compatibility and ease of use in a studio setup.
Operating the Oxygen 49 IV
Key Features Overview

Figure 3: Top-down view of the Oxygen 49 IV, showcasing its 49 velocity-sensitive keys, 8 assignable knobs, 9 assignable faders, and 8 velocity-sensitive trigger pads.
- 49 Velocity-Sensitive Keys: Full-size, synth-action keys for playing melodies, chords, and bass lines with expressive dynamics.
- 8 Velocity-Sensitive Trigger Pads: Ideal for beat production, triggering samples, or finger drumming.
- 8 Assignable Knobs: For tweaking effect plugins, virtual instruments, and other DAW parameters.
- 9 Assignable Faders: Perfect for controlling master output, mixing tracks, or adjusting instrument levels.
- Pitch Bend and Modulation Wheels: For expressive performance control.
- Dedicated Transport Controls: Play, stop, record, and navigate within your DAW directly from the keyboard.
- LCD Screen: Provides instant parameter feedback for easy navigation and control.
Using the Controls
The Oxygen 49 IV offers extensive control over your music software. Each knob, fader, and pad can be assigned to various functions within your DAW or virtual instruments. The onboard LCD screen assists in identifying and adjusting parameters.

Figure 4: Detailed view of the assignable knobs and faders on the Oxygen 49 IV, used for precise control over software parameters.
The 8 velocity-sensitive trigger pads respond to the force of your touch, allowing for dynamic drum programming and sample triggering.

Figure 5: A hand demonstrating the use of the velocity-sensitive trigger pads on the Oxygen 49 IV, which illuminate upon activation.
Octave and Transport Controls
Dedicated Octave Up and Down buttons allow you to instantly shift the keyboard's melodic range, providing access to the full spectrum of notes. The transport buttons (Play, Stop, Record) enable direct control over your DAW's playback and recording functions, enhancing workflow efficiency.

Figure 6: Close-up of the pitch bend and modulation wheels, along with the Octave Up/Down buttons, offering expressive control and range adjustment.
Maintenance
To ensure the longevity and optimal performance of your Oxygen 49 IV, follow these maintenance guidelines:
- Cleaning: Use a soft, dry cloth to wipe down the surface of the keyboard. For stubborn dirt, a slightly damp cloth with mild soap can be used, but ensure no liquid enters the device. Avoid abrasive cleaners or solvents.
- Storage: Store the keyboard in a cool, dry place away from direct sunlight, extreme temperatures, and high humidity. Protect it from dust when not in use, ideally with a dust cover.
- Handling: Avoid dropping the device or subjecting it to strong impacts. Do not place heavy objects on top of the keyboard.
Troubleshooting
If you encounter issues with your Oxygen 49 IV, consider the following common troubleshooting steps:
- No Power/No Response:
- Ensure the USB cable is securely connected to both the keyboard and your computer.
- Try a different USB port on your computer.
- If using a USB hub, ensure it is powered.
- Keys/Pads Not Responding:
- Verify that the Oxygen 49 IV is selected as the MIDI input device in your DAW's preferences.
- Check if any local control settings on the keyboard are preventing MIDI output.
- Ensure the correct MIDI channel is selected in your software.
- Controls Not Mapping Correctly:
- Re-enable DirectLink in your DAW's settings.
- Manually assign controls within your DAW if DirectLink is not functioning as expected. Refer to your DAW's manual for MIDI mapping instructions.
- Intermittent Connectivity:
- Avoid connecting the keyboard through long or unshielded USB cables.
- Minimize other USB devices connected to the same hub or computer if experiencing issues.
For further assistance, consult the official M-Audio support resources or the comprehensive user manual available online.
Specifications
| Feature | Detail |
|---|---|
| Model Name | Oxygen 49 IV |
| Number of Keys | 49 |
| Connectivity Technology | USB |
| Hardware Interface | USB |
| Supported Software | Ableton Live (and other DAWs via DirectLink) |
| Item Weight | 6.39 pounds |
| Product Dimensions | 9.56 x 32.04 x 3.7 inches |
| Color Name | MultiColored |
| Proficiency Level | All |
Warranty and Support
For detailed warranty information and technical support, please visit the official M-Audio website. You can also find the comprehensive User Manual (PDF) for this product at M-Audio Oxygen 49 IV User Manual.
M-Audio provides resources to help you get the most out of your Oxygen 49 IV, including FAQs, software downloads, and contact information for customer service.





