1. Introduction
This manual provides detailed instructions for the installation, configuration, and operation of your ASUS M5A78L-M LX Micro ATX Motherboard. This motherboard supports AMD AM3+ processors, DDR3 memory, and features integrated AMD 760G graphics with Hybrid CrossFireX support. Please read this manual thoroughly before beginning installation to ensure proper setup and optimal performance.
2. Safety Information
- Always disconnect the power cord from the wall outlet before touching any internal components.
- Wear an anti-static wrist strap or frequently touch a grounded metal object to prevent electrostatic discharge (ESD) damage to components.
- Handle components by their edges, avoiding contact with pins or circuitry.
- Ensure proper ventilation within your computer case to prevent overheating.
- Keep the motherboard away from moisture and extreme temperatures.
3. Setup and Installation
3.1 Package Contents
Verify that your package contains the following items:
- ASUS M5A78L-M LX Motherboard
- I/O Shield
- SATA Data Cables (x2)
- User Manual
- Support DVD (with drivers and utilities)
3.2 Motherboard Layout
Familiarize yourself with the various components and connectors on the motherboard.

Image 1: Top-down view of the ASUS M5A78L-M LX motherboard, highlighting the CPU socket, RAM slots, PCIe slots, and various headers. The blue heatsinks and slots are clearly visible.
3.3 CPU Installation
- Locate the AM3+ CPU socket on the motherboard.
- Lift the CPU socket lever.
- Carefully align the CPU with the socket, ensuring the golden triangle on the CPU matches the triangle on the socket.
- Gently lower the CPU into the socket without forcing it.
- Lower the CPU socket lever to secure the CPU.
- Apply thermal paste and install the CPU cooler according to its manufacturer's instructions.
3.4 Memory (RAM) Installation
- Open the clips at both ends of the DDR3 DIMM slots.
- Align the memory module with the slot, ensuring the notch on the module matches the key in the slot.
- Press down firmly on both ends of the memory module until the clips snap into place.
- For dual-channel operation, install modules in matching colored slots (e.g., both blue slots).
3.5 Motherboard Mounting
- Install the I/O shield into the rear opening of your computer case.
- Align the motherboard with the standoffs inside the case.
- Secure the motherboard with screws, ensuring it is firmly seated but not overtightened.
3.6 Connecting Peripherals and Power
Connect all necessary cables to the motherboard, including:
- 24-pin ATX power connector
- 4-pin ATX 12V power connector (CPU power)
- SATA data cables for storage drives
- Front panel connectors (power button, reset button, LEDs, USB, audio)
- USB 2.0 headers
- Fan headers

Image 2: Angled view of the ASUS M5A78L-M LX motherboard, showing the rear I/O ports, SATA ports, and various expansion slots. This perspective highlights the connectivity options.
4. Operating Instructions
4.1 BIOS Setup
The BIOS (Basic Input/Output System) is the firmware that initializes your hardware during startup. To enter BIOS Setup, press the DEL key during the Power-On Self-Test (POST). Key BIOS settings include:
- Boot Order: Configure the sequence of storage devices for booting the operating system.
- CPU Configuration: Adjust CPU-related settings, including Core Unlocker for compatible processors.
- Memory Settings: Configure DDR3 memory frequency and timings.
- Integrated Graphics: Adjust settings for the onboard AMD 760G graphics.
4.2 Driver Installation
After installing your operating system, install the necessary drivers from the provided Support DVD or download the latest versions from the ASUS website. Essential drivers include:
- Chipset Drivers
- Graphics Drivers (for integrated or discrete GPU)
- Audio Drivers
- LAN Drivers
- USB Drivers
4.3 ASUS Exclusive Features
- Core Unlocker: This feature allows users to unlock hidden CPU cores on certain AMD processors, potentially increasing performance. Access this setting in the BIOS.
- EPU Technology: ASUS EPU (Energy Processing Unit) provides system-level energy saving and real-time power management for improved platform power efficiency.
- Anti-Surge Protection: Safeguards your device by providing voltage protection to all major onboard components.
- Turbo Key: A hardware button or software utility that allows for instant system performance boosts.
5. Maintenance
5.1 Cleaning
Regularly clean your computer's interior to prevent dust buildup, which can lead to overheating and component failure. Use compressed air to remove dust from fans, heatsinks, and other components. Ensure the system is powered off and unplugged before cleaning.
5.2 BIOS Updates
Periodically check the ASUS support website for updated BIOS versions. BIOS updates can improve system stability, add support for new hardware, or fix known issues. Follow the instructions provided by ASUS carefully when performing a BIOS update to avoid system damage.
6. Troubleshooting
If you encounter issues with your motherboard, refer to the following common troubleshooting steps:
- No Display: Ensure the monitor is connected to the correct video output (onboard or discrete graphics card). Check that RAM modules are properly seated. Try clearing the CMOS (refer to motherboard manual for jumper location).
- System Fails to Boot: Verify all power connections (24-pin ATX, 4-pin 12V CPU). Check CPU and RAM installation. Disconnect non-essential peripherals.
- System Instability/Crashes: Ensure all drivers are installed and up-to-date. Check for overheating by monitoring CPU and GPU temperatures. Test memory modules individually.
- Peripheral Not Detected: Ensure the device is properly connected. Check BIOS settings for port enablement. Install necessary drivers for the peripheral.
For more advanced troubleshooting or persistent issues, contact ASUS technical support.
7. Specifications
| Feature | Specification |
|---|---|
| Brand | ASUS |
| Model Name | M5A78L-M LX |
| CPU Socket | Socket AM3+ |
| Chipset Type | AMD 760G |
| Compatible Processors | AMD Phenom II, AMD Athlon II, AMD Sempron, AMD A4, AMD A6, AMD A8, AMD A10 |
| RAM Memory Technology | DDR3 1866; DDR3 1600; DDR3 1333; DDR3 1066 |
| Memory Clock Speed | 1600 MHz |
| Compatible Devices | Personal Computer |
| Platform | Windows 10 (and earlier versions) |
| Item Weight | 1.85 pounds |
| Package Dimensions | 10.9 x 10.4 x 2.1 inches |
8. Warranty and Support
ASUS products are designed and manufactured to the highest quality standards. For information regarding your product's warranty, please refer to the warranty card included with your purchase or visit the official ASUS website.
For technical support, driver downloads, and further product information, please visit the official ASUS support page:





