1. Introduction
The Moxa UPort 1650-16 is a high-performance 16-port USB-to-serial hub designed to expand serial connectivity for computers lacking built-in serial ports. It provides reliable RS-232/422/485 serial communication over a single USB connection, making it suitable for industrial automation, point-of-sale, and data acquisition applications. This manual provides essential information for the proper installation, operation, and maintenance of your UPort 1650-16 device.
2. Key Features
- Hi-Speed USB 2.0 for up to 480 Mbps USB data transmission rates.
- Maximum baud rate of 921.6 kbps for fast data transmission.
- Drivers provided for Windows, WinCE, and Linux operating systems.
- Includes a Mini-DB9-female-to-terminal-block adapter for simplified wiring.
- LED indicators for monitoring USB and TxD/RxD activity on each port.
- 2 kV isolation protection (for "-I" models) to enhance system reliability.
3. Package Contents
Before proceeding with installation, verify that your package contains the following items:
- Moxa UPort 1650-16 USB to Serial Hub
- USB Type-A to Type-B Cable
- Power Adapter (if external power supply is required for your model)
- Documentation CD or Link to Driver Download
- Mini-DB9-female-to-terminal-block adapters (16 units)
If any items are missing or damaged, please contact your vendor immediately.
4. Hardware Description
The UPort 1650-16 features a robust design with clearly labeled ports and indicators.

Figure 1: Top-down view of the Moxa UPort 1650-16, showing the overall chassis and branding.

Figure 2: Front panel of the Moxa UPort 1650-16, displaying 16 serial ports with corresponding Tx/Rx and Active LEDs, and the UPort 1650-16 model designation.
Front Panel
- Serial Ports (1-16): 16 DB9 male connectors for RS-232/422/485 serial devices.
- Tx/Rx LEDs: Indicate data transmission (Tx) and reception (Rx) activity for each serial port.
- Active LED: Indicates the operational status of the device.
Rear Panel (Typical Configuration)
- USB Type-B Port: Connects to the host computer via a USB cable.
- Power Input: For connecting the external power adapter.
- Grounding Screw: For proper grounding to prevent electrical interference.
5. Setup and Installation
5.1 Driver Installation
- Obtain Drivers: Download the latest drivers for your operating system (Windows, WinCE, Linux) from the official Moxa website. Alternatively, use the provided driver CD if available.
- Install Drivers: Follow the on-screen instructions to install the drivers. It is recommended to install drivers before connecting the UPort 1650-16 to your computer.
- Restart (if prompted): If prompted, restart your computer to complete the driver installation.
5.2 Hardware Connection
- Power Off: Ensure your computer and any serial devices are powered off before making connections.
- Connect USB Cable: Connect one end of the USB Type-A to Type-B cable to the UPort 1650-16's USB Type-B port and the other end to an available USB port on your host computer.
- Connect Power: If your model requires external power, connect the power adapter to the UPort 1650-16's power input and then plug it into a suitable power outlet.
- Grounding (Recommended): Connect a grounding wire from the UPort 1650-16's grounding screw to a proper earth ground.
- Connect Serial Devices: Connect your RS-232/422/485 serial devices to the DB9 serial ports on the front panel of the UPort 1650-16. Use the provided Mini-DB9-female-to-terminal-block adapters for wiring if necessary.
- Power On: Power on your computer and the UPort 1650-16. The Active LED on the front panel should illuminate.
After successful installation, the UPort 1650-16 will be recognized by your operating system, and virtual COM ports will be assigned to each serial port.
6. Operating Instructions
6.1 Verifying COM Port Assignment
After driver installation and hardware connection, verify the assigned COM port numbers:
- Windows: Open Device Manager (right-click "This PC" or "My Computer" > Manage > Device Manager). Expand "Ports (COM & LPT)" to see the Moxa UPort serial ports and their assigned COM numbers.
- Linux: Use commands like
dmesg | grep ttyUSBor check/dev/ttyUSB*to identify the serial devices.
6.2 Communicating with Serial Devices
Use your preferred serial communication software (e.g., PuTTY, Tera Term, HyperTerminal, custom applications) to interact with your connected serial devices. Configure the software with the correct COM port number, baud rate, data bits, parity, and stop bits as required by your serial device.
- Baud Rate: Up to 921.6 kbps.
- Data Bits: 5, 6, 7, or 8.
- Parity: None, Odd, Even, Mark, Space.
- Stop Bits: 1, 1.5, or 2.
- Flow Control: None, RTS/CTS, XON/XOFF.
Observe the Tx/Rx LEDs on the front panel; they will flash when data is being transmitted or received on the corresponding port.
7. Maintenance
The Moxa UPort 1650-16 is designed for reliable operation with minimal maintenance. Follow these guidelines to ensure optimal performance and longevity:
- Cleaning: Keep the device clean and free from dust. Use a soft, dry cloth for cleaning. Avoid liquid cleaners or solvents.
- Environment: Operate the device within its specified temperature and humidity ranges. Avoid exposing it to extreme temperatures, direct sunlight, or excessive moisture.
- Cable Management: Ensure all cables are securely connected and properly routed to prevent strain or damage.
- Firmware Updates: Periodically check the Moxa website for firmware updates. Apply updates as recommended by the manufacturer to enhance performance or address issues.
8. Troubleshooting
If you encounter issues with your UPort 1650-16, consider the following troubleshooting steps:
- Device Not Detected:
- Ensure the USB cable is securely connected to both the UPort and the computer.
- Verify that the power adapter is connected and the device is powered on (Active LED illuminated).
- Check Device Manager (Windows) or
dmesg(Linux) to see if the device is recognized. Reinstall drivers if necessary. - Try a different USB port on your computer or a different USB cable.
- No Communication with Serial Device:
- Confirm the correct COM port is selected in your serial communication software.
- Verify that the baud rate, data bits, parity, and stop bits settings match those of your serial device.
- Check the serial cable connection between the UPort and your device. Ensure it's a straight-through or null-modem cable as required.
- Observe the Tx/Rx LEDs. If they are not flashing during communication attempts, there might be an issue with the serial device or its configuration.
- Intermittent Connection:
- Ensure proper grounding of the UPort 1650-16.
- Check for electromagnetic interference (EMI) from other equipment.
- Verify the integrity of the USB and serial cables.
If problems persist, consult the Moxa support website or contact technical support.
9. Specifications
| Feature | Detail |
|---|---|
| Product Dimensions | 17.32 x 1.79 x 7.8 inches |
| Item Weight | 7.66 pounds |
| Manufacturer | MOXA |
| Item Model Number | UPort 1650-16 |
| Brand | Moxa |
| Hardware Interface | USB |
| Compatible Devices | Laptops |
| Total USB Ports | 16 (for serial connectivity) |
| Data Transfer Rate | 480 Megabits Per Second (USB 2.0) |
| Max Baudrate | 921.6 kbps |
| Serial Standards | RS-232/422/485 |
| Isolation Protection | 2 kV (for "-I" models) |
10. Warranty and Support
For detailed warranty information, please refer to the warranty card included with your product or visit the official Moxa website. Moxa provides technical support and resources to assist with product inquiries, troubleshooting, and driver updates.
Moxa Official Website: www.moxa.com
It is recommended to register your product on the Moxa website to receive updates and access support services.





