Frontline 72219

Frontline Plus for Dogs Flea and Tick Treatment User Manual

Brand: Frontline

Product Overview

Frontline Plus for Dogs is a topical flea and tick treatment designed for large dogs weighing 45 to 88 pounds. This fast-acting, long-lasting, and waterproof solution effectively kills fleas, flea eggs, flea larvae, chewing lice, and ticks, including those that may transmit Lyme disease. It is formulated with fipronil and (S)-methoprene to break the flea life cycle and prevent further infestations. Trusted by pet owners for over 20 years, Frontline Plus can be used on puppies as young as eight weeks old, weighing 5 pounds or more. Applied monthly to a single spot on your dog, the treatment spreads across the body and is stored in the sebaceous glands, providing continuous protection even if your dog gets wet.

Frontline Plus for Dogs Large Dog 6 Doses product box

Image: Frontline Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses product packaging.

Key Features:

  • Provides fast-acting, long-lasting flea and tick protection for pets 8 weeks or older.
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae.
  • Waterproof 24 hours after application.
  • Easy to apply once a month for lasting protection.
  • For best results, apply every month.

Safety Information

For external use only. Do not use on puppies under 8 weeks of age and less than 5 lbs. Individual sensitivities, while rare, may occur after using any pesticide product. Always read the full product label and directions before use.

Diagram showing flea life cycle and pests killed by Frontline Plus

Image: Visual representation of the flea life cycle and the types of pests (adult fleas, flea eggs, flea larvae, ticks, chewing lice) that Frontline Plus targets.

Ingredients

Active Ingredients:

  • Fipronil (9.8%)
  • (S)-Methoprene (8.8%)

Directions for Use

Application Steps:

  1. Step 1. To REMOVE Applicator:
    • Use scissors to separate one blister.
    • Use scissors to cut along dotted line.
    • Peel down foil to remove the applicator.
    Illustration of how to open the Frontline Plus applicator packaging

    Image: Step-by-step illustration for removing the applicator from its packaging.

  2. Step 2. OPEN Applicator: Hold upright with foil side toward you and snap applicator tip.
  3. Step 3. APPLY FRONTLINE Plus: Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product.
    Illustration of parting dog's hair and applying Frontline Plus

    Image: Illustration demonstrating how to part the dog's hair and apply the liquid directly to the skin between the shoulder blades.

Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month.

Frequency:

Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Illustration of Frontline Plus spreading through dog's coat

Image: Illustration showing the topical treatment spreading naturally through the dog's coat after application.

Maintenance

Consistent monthly application is key to maintaining effective flea and tick control. Ensure all pets in the household are treated appropriately and regularly to prevent re-infestation and break the flea life cycle. The product is waterproof 24 hours after application, allowing normal bathing and swimming routines to continue without compromising efficacy.

Troubleshooting

While Frontline Plus is generally well-tolerated, individual sensitivities can occur. Observe your dog closely after application for any adverse reactions.

Potential Adverse Reactions (Rare):

  • Restlessness
  • Itching
  • Vomiting
  • Difficulty Breathing
  • Lethargy

Important: Should any of these symptoms occur, immediately contact your veterinarian or an emergency veterinary clinic.

If you notice fleas or ticks after application, ensure the product was applied directly to the skin and not just the hair. Also, confirm that the correct dosage for your dog's weight was used and that monthly applications are consistent. Severe infestations may require additional environmental control measures in your home.

Specifications

AttributeDetail
Brand NameFrontline
Model NameFRONTLINE Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses
Item Model Number72219
Target AudienceDogs (45 to 88 pounds), 8 weeks and older
Item FormLiquid
ScentUnscented
Active IngredientsFipronil and (S)-methoprene
Item Volume1 Milliliters (per applicator)
Number of Items1 (Package includes 6 applicators)
Item Weight0.2 Ounces
Product Dimensions5.75 x 1 x 4.5 inches
ManufacturerBoehringer Ingelheim Animal Health
Country of OriginFrance / United States
Date First AvailableOctober 2, 2001

Warranty and Support

Frontline Plus for Dogs is manufactured by Boehringer Ingelheim Animal Health.

The product is warranted for use only on dogs.

For detailed information, frequently asked questions, or to explore other Frontline products, please refer to the official resources:

For specific concerns or medical advice regarding your pet, always consult with a licensed veterinarian.

© 2025 Frontline. All rights reserved. Product information is subject to change.

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