Product Overview
Frontline Plus for Dogs is a topical flea and tick treatment designed for large dogs weighing 45 to 88 pounds. This fast-acting, long-lasting, and waterproof solution effectively kills fleas, flea eggs, flea larvae, chewing lice, and ticks, including those that may transmit Lyme disease. It is formulated with fipronil and (S)-methoprene to break the flea life cycle and prevent further infestations. Trusted by pet owners for over 20 years, Frontline Plus can be used on puppies as young as eight weeks old, weighing 5 pounds or more. Applied monthly to a single spot on your dog, the treatment spreads across the body and is stored in the sebaceous glands, providing continuous protection even if your dog gets wet.

Image: Frontline Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses product packaging.
Key Features:
- Provides fast-acting, long-lasting flea and tick protection for pets 8 weeks or older.
- Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae.
- Waterproof 24 hours after application.
- Easy to apply once a month for lasting protection.
- For best results, apply every month.
Safety Information
For external use only. Do not use on puppies under 8 weeks of age and less than 5 lbs. Individual sensitivities, while rare, may occur after using any pesticide product. Always read the full product label and directions before use.

Image: Visual representation of the flea life cycle and the types of pests (adult fleas, flea eggs, flea larvae, ticks, chewing lice) that Frontline Plus targets.
Ingredients
Active Ingredients:
- Fipronil (9.8%)
- (S)-Methoprene (8.8%)
Directions for Use
Application Steps:
- Step 1. To REMOVE Applicator:
- Use scissors to separate one blister.
- Use scissors to cut along dotted line.
- Peel down foil to remove the applicator.

Image: Step-by-step illustration for removing the applicator from its packaging.
- Step 2. OPEN Applicator: Hold upright with foil side toward you and snap applicator tip.
- Step 3. APPLY FRONTLINE Plus: Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product.

Image: Illustration demonstrating how to part the dog's hair and apply the liquid directly to the skin between the shoulder blades.
Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month.
Frequency:
Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Image: Illustration showing the topical treatment spreading naturally through the dog's coat after application.
Maintenance
Consistent monthly application is key to maintaining effective flea and tick control. Ensure all pets in the household are treated appropriately and regularly to prevent re-infestation and break the flea life cycle. The product is waterproof 24 hours after application, allowing normal bathing and swimming routines to continue without compromising efficacy.
Troubleshooting
While Frontline Plus is generally well-tolerated, individual sensitivities can occur. Observe your dog closely after application for any adverse reactions.
Potential Adverse Reactions (Rare):
- Restlessness
- Itching
- Vomiting
- Difficulty Breathing
- Lethargy
Important: Should any of these symptoms occur, immediately contact your veterinarian or an emergency veterinary clinic.
If you notice fleas or ticks after application, ensure the product was applied directly to the skin and not just the hair. Also, confirm that the correct dosage for your dog's weight was used and that monthly applications are consistent. Severe infestations may require additional environmental control measures in your home.
Specifications
| Attribute | Detail |
|---|---|
| Brand Name | Frontline |
| Model Name | FRONTLINE Plus for Dogs Large Dog (45 to 88 pounds) Flea and Tick Treatment, 6 Doses |
| Item Model Number | 72219 |
| Target Audience | Dogs (45 to 88 pounds), 8 weeks and older |
| Item Form | Liquid |
| Scent | Unscented |
| Active Ingredients | Fipronil and (S)-methoprene |
| Item Volume | 1 Milliliters (per applicator) |
| Number of Items | 1 (Package includes 6 applicators) |
| Item Weight | 0.2 Ounces |
| Product Dimensions | 5.75 x 1 x 4.5 inches |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Country of Origin | France / United States |
| Date First Available | October 2, 2001 |
Warranty and Support
Frontline Plus for Dogs is manufactured by Boehringer Ingelheim Animal Health.
The product is warranted for use only on dogs.
For detailed information, frequently asked questions, or to explore other Frontline products, please refer to the official resources:
- Instructions for Use (IFU) PDF
- User Guide PDF
- Visit the official Frontline Store for additional support and product information: Frontline Store on Amazon
For specific concerns or medical advice regarding your pet, always consult with a licensed veterinarian.



