1. Overview
Life Extension Pro-Resolving Mediators is a dietary supplement formulated to support the body's natural post-inflammatory response. It provides specialized pro-resolving mediators (PRMs) and their precursors, including 18-HEPE, 17-HDHA, and 14-HDHA, derived from marine lipid concentrate. These compounds are essential for healthy tissue rejuvenation, efficient clearance of cellular debris, and maintaining a balanced cytokine response.

Image 1.1: Front view of the Life Extension Pro-Resolving Mediators supplement bottle.
Key Benefits:
- Tissue Rejuvenation: Supports the body's natural processes for revitalizing skin, organs, and other vital tissues.
- Cellular Debris Clearance: Encourages existing pathways for naturally removing cellular debris and recycling cells that no longer function optimally.
- Cytokine Balance: Helps maintain a natural, healthy balance between cytokine compounds, which are released by immune cells to govern various bodily processes.

Image 1.2: Visual representation of the supplement's benefits, including tissue rejuvenation and cellular debris clearance.

Image 1.3: Explanation of pro-resolving mediators' role in tissue health.
2. Setup and Preparation
Before using the Life Extension Pro-Resolving Mediators supplement, please ensure the product is in good condition and review the following guidelines.
Initial Inspection:
- Inspect the outer seal of the bottle. Do not purchase or use if the outer seal is broken or damaged.
- Verify the expiration date printed on the bottle.
Consultation:
As with any nutritional supplement, it is recommended to consult with your physician if you are:
- Undergoing treatment for a medical condition.
- Pregnant or lactating.
3. Operating (Usage Instructions)
Follow these instructions for proper use of the Life Extension Pro-Resolving Mediators supplement.
Dosage:
- Take one (1) softgel daily.
- Alternatively, follow the dosage recommended by a healthcare practitioner.

Image 3.1: Recommended daily dosage and supply information.
Important Considerations:
- DO NOT EXCEED RECOMMENDED DOSE.
- This product is intended for adult use.

Image 3.2: Directions and warnings for the supplement.
4. Maintenance (Storage)
Proper storage ensures the quality and efficacy of your supplement.
Storage Instructions:
- Store the bottle tightly closed.
- Keep in a cool, dry place.
- KEEP OUT OF REACH OF CHILDREN.
5. Troubleshooting
If you experience any issues or have concerns regarding the supplement, please refer to the following guidance.
Adverse Events:
If you experience a serious adverse event, discontinue use and consult your physician immediately. To report a serious adverse event or obtain product information, contact Life Extension directly.
6. Specifications
| Feature | Detail |
|---|---|
| Product Name | Pro-Resolving Mediators |
| Brand | Life Extension |
| Model Number | 02223 |
| UPC | 737870222330 |
| Item Form | Softgel |
| Unit Count | 30 Count |
| Total Servings Per Container | 30 |
| Product Dimensions | 1.86 x 1.86 x 3.41 inches |
| Item Weight | 1.76 ounces (0.11 Pounds) |
| Diet Type | Gluten Free |
| Material Features | GMO Free |
| Special Ingredients | Marine Lipid Concentrate |
| Flavor | Unflavored |
| Color | Light Golden |
| Age Range Description | Adult |
| Manufacturer | AmazonUs/LJHZZ |
| Date First Available | October 2, 2019 |

Image 6.1: Supplement Facts panel from the back of the bottle.
7. Ingredients
Each serving (1 softgel) contains:
- Calories: 5
- Total Fat: 0.5 g (1% Daily Value)
- Cholesterol: <5 mg (<2% Daily Value)
- Marine Lipid Concentrate: 500 mg (providing 300 mcg of Pro-Resolving Mediators including 18-hydroxyeicosapentaenoic acid (18-HEPE), 17-hydroxydocosahexaenoic acid (17-HDHA), & 14-hydroxydocosahexaenoic acid (14-HDHA))
Other Ingredients: Highly refined marine oil concentrate (squid, anchovy, sardine, herring, mackerel), gelatin, olive oil, glycerin, purified water, lemon flavor, mixed tocopherols.
*Daily Value not established. % Daily Values are based on a 2,000 calorie diet.
8. Warnings
- KEEP OUT OF REACH OF CHILDREN.
- DO NOT EXCEED RECOMMENDED DOSE.
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease or health condition.
9. Official Product Video
Video 9.1: Official product video from Life Extension HPC, providing an overview of Pro-Resolving Mediators and their benefits. Duration: 0:47.
10. Support
For further assistance, product information, or to report a serious adverse event, please contact the manufacturer directly.
- Manufacturer Contact: 1-866-280-2852
- Manufacturer: Quality Supplements and Vitamins, Inc. Ft. Lauderdale, FL 33309
- Website: LifeExtension.com
- Life Extension Store: Visit the Life Extension Store on Amazon