1. Introduction
This manual provides detailed instructions for the installation, configuration, and operation of your ASUS X99-A II motherboard. Please read this manual thoroughly before installing your system components to ensure proper setup and functionality.
Product Overview
The ASUS X99-A II is an ATX motherboard designed for Intel Core i7 X-Series Processors utilizing the LGA2011-v3 socket. It integrates 5-Way Optimization for comprehensive system tuning, advanced connectivity options including onboard USB 3.1 Type-C, U.2, and M.2 slots, and ASUS Aura RGB lighting for customizable aesthetics. The motherboard also features ASUS SafeSlot for enhanced PCIe slot durability.
Key Features:
- Next-Gen Connectivity: Includes onboard U.2 / M.2 slots that utilize 32Gbps of PCIe bandwidth, as well as onboard USB 3.1 Type-C.
- ASUS Aura RGB Lighting: Features controllable RGB onboard lighting and a 4-pin strip header that can be synchronized with compatible ASUS hardware for customizable visual effects.
- SafeSlot: A patent-pending, reinforced PCIe slot design that uses an insert-molding process to bind the slot to fortifying metal, providing superior retention and shearing resistance for graphics cards.
- 5-Way Optimization with Fan Xpert 4: Elevates customized cooling to new heights with automatic PWM/DC fan detection on all headers. This feature allows for the utilization of high-amperage fans and water-cooling pumps, configurable through software and UEFI.
- Crystal Sound 3: Gaming-grade audio solution featuring a new power pre-regulator for clean power delivery, combined with ASUS-pioneered noise isolation design and premium audio components for clear and immersive sound.
2. Package Contents
Please verify that all items are present in your motherboard package. If any item is missing or damaged, contact your retailer.
- ASUS X99-A II Motherboard
- Serial ATA 6.0Gb/s cables (4)
- RGB LED extension cable
- CPU Installation Tool
- ASUS SLI bridge
- ASUS Q-Shield (I/O Shield)
- M.2 screw package
- User's manual (this document)
- Supporting DVD (drivers and utilities)
3. System Setup
This section guides you through the physical installation of the motherboard and its components into your computer chassis.
3.1 Motherboard Layout
Familiarize yourself with the main components and connectors on the ASUS X99-A II motherboard before proceeding with installation.

Image: Top-down view of the ASUS X99-A II motherboard, illustrating the CPU socket, DIMM slots, PCIe slots, and various headers.

Image: Close-up view of the rear input/output (I/O) panel of the ASUS X99-A II motherboard, showing USB ports, Ethernet, audio jacks, and other connectors.

Image: Detailed view of the PCIe expansion slots and the M.2 slot on the ASUS X99-A II motherboard, illustrating their placement and configuration.
3.2 CPU Installation (LGA2011-v3)
- Ensure the CPU socket lever is open.
- Carefully align the CPU with the socket, matching the golden triangle on the CPU to the triangle indicator on the socket.
- Gently place the CPU into the socket without forcing it.
- Close the socket lever to secure the CPU.
- Install the CPU cooler according to its manufacturer's instructions.
3.3 Memory Installation (DDR4 SDRAM)
The ASUS X99-A II supports DDR4 SDRAM. Refer to the motherboard manual for recommended memory configurations and slot priority for optimal performance.
- Open the clips at both ends of the DIMM slot.
- Align the memory module with the slot, ensuring the notch on the module matches the key in the slot.
- Press down firmly on both ends of the memory module until the clips snap into place, securing the module.
3.4 Storage Device Installation
SATA Devices
Connect SATA storage devices (Hard Disk Drives, Solid State Drives) to the SATA 6.0Gb/s ports using the provided SATA cables.
M.2 and U.2 Devices
The motherboard features M.2 and U.2 slots for high-speed storage. Install M.2 drives by inserting them into the slot and securing them with the M.2 screw package. U.2 drives require a compatible cable (not included) to connect to the onboard U.2 connector.
Important Note for M.2 Users: If you plan to use an M.2 drive, be aware that enabling XMP (Extreme Memory Profile) for memory overclocking may impact M.2 bandwidth. Consult the UEFI/BIOS settings for specific configurations and potential limitations.
3.5 Expansion Card Installation (PCIe)
Install graphics cards and other expansion cards into the appropriate PCIe slots. The SafeSlot design provides enhanced durability for heavy graphics cards.
- Align the expansion card with the chosen PCIe slot.
- Press down firmly until the card is seated correctly and the retention clip locks.
- Secure the card to the chassis with a screw.
3.6 Connecting Peripherals and Power
Connect your power supply unit (PSU) to the motherboard's 24-pin ATX power connector and the 8-pin CPU power connector. Connect front panel headers (USB, audio, power/reset switches, LEDs) according to the motherboard's pinout diagram. Connect external peripherals to the rear I/O ports.
4. Operating Instructions
4.1 First Boot and BIOS/UEFI Setup
After assembling your system, power it on. Press the 'Delete' key during startup to enter the BIOS/UEFI setup utility. Here you can configure boot order, system time, and various hardware settings.
4.2 Driver and Utility Installation
Insert the provided Supporting DVD to install necessary drivers for the chipset, audio, network, and other components. Install ASUS utilities such as AI Suite 3 for 5-Way Optimization and Fan Xpert 4, and ASUS Aura for RGB lighting control.
4.3 ASUS Aura RGB Lighting
Use the ASUS Aura software to customize the onboard RGB lighting and synchronize it with compatible RGB LED strips connected to the 4-pin header on the motherboard.
4.4 5-Way Optimization and Fan Xpert 4
The 5-Way Optimization feature allows for one-click system tuning, including CPU overclocking, power efficiency, digital power control, and advanced fan control via Fan Xpert 4. This utility can automatically detect and calibrate connected fans and water-cooling pumps for optimal cooling and noise levels.
4.5 Crystal Sound 3 Audio Configuration
Ensure the audio drivers are installed for optimal performance of the Crystal Sound 3 audio solution. Configure audio settings through your operating system's sound control panel or the dedicated audio utility provided by ASUS.
5. Maintenance
To ensure the longevity and optimal performance of your ASUS X99-A II motherboard, follow these maintenance guidelines:
- Dust Removal: Regularly clean dust from the motherboard and components using compressed air. Ensure the system is powered off and unplugged from the wall outlet before cleaning.
- BIOS Updates: Periodically check the official ASUS support website for BIOS/UEFI updates. Updates can improve system stability, component compatibility, and overall performance. Always follow the provided update instructions carefully.
- Driver Updates: Keep your system drivers updated to ensure compatibility and optimal performance with your operating system and applications.
6. Troubleshooting
This section addresses common issues you might encounter during system setup or operation.
- No Power/No Boot:
- Verify all power cables (24-pin ATX, 8-pin CPU) are securely connected to the motherboard and power supply.
- Ensure the power supply unit (PSU) is switched on at the back.
- Check the front panel power switch connections to the motherboard.
- Q-Code 00 Error: This diagnostic code often indicates a CPU or memory initialization issue.
- Reseat the CPU and carefully check for any bent pins in the socket.
- Reseat all memory modules. Try booting with only one memory module installed in the primary slot.
- Ensure the CPU cooler is properly installed and making good contact with the CPU.
- Display Issues:
- Ensure the graphics card is fully seated in its PCIe slot and all auxiliary power connectors are attached.
- Verify the monitor cable is securely connected to the graphics card and the monitor.
- System Instability/Crashes:
- Check for proper CPU and GPU cooling; ensure fans are spinning and heatsinks are clear of dust.
- Ensure memory modules are compatible with your motherboard and correctly installed.
- Update drivers for all components and the motherboard BIOS/UEFI to the latest versions.
For more detailed troubleshooting steps and advanced diagnostics, refer to the comprehensive user manual on the Supporting DVD or visit the official ASUS support website.
7. Technical Specifications
| Feature | Specification |
|---|---|
| Brand | ASUS |
| Model Name | X99-A II |
| CPU Socket | LGA 2011-3 |
| Compatible Processors | Intel Core i7 X-Series |
| Chipset Type | Intel X99 |
| Memory Type | DDR4 SDRAM (DIMM) |
| Memory Speed | Up to 2400 MHz (and higher via overclocking) |
| USB 2.0 Ports | 4 (rear I/O) |
| Form Factor | ATX (12.0 inch x 9.6 inch / 30.5 cm x 24.4 cm) |
| Product Dimensions (LxWxH) | 10.35 x 2.68 x 12.91 inches |
| Item Weight | 4.2 pounds |
| First Available Date | May 6, 2016 |
8. Warranty and Support
For detailed warranty information, please refer to the warranty card included with your ASUS X99-A II motherboard or visit the official ASUS support website. ASUS provides comprehensive technical support and resources for its products.
ASUS Support Website: https://www.asus.com/support/
When contacting support, please have your product model (X99-A II) and serial number readily available.





