Introduction
This manual provides essential information for the proper use and understanding of your THORNE Methyl-Guard Methylation Support Supplement. It contains Folate and Vitamin B12 to support healthy methylation. Please read thoroughly before use.
Key Benefits
- Methylation Support: Aids in healthy methylation processes.
- Multiple Functions: Supports heart, blood vessel, brain, nerve, and bone health.
- Homocysteine Metabolism: Promotes healthy homocysteine metabolism.
- Active B Vitamins: Contains active, methylated forms of folate (5-MTHF) and vitamin B12 (methylcobalamin).
Ingredients
Each serving (three capsules) contains:
- Vitamin B6 (as Pyridoxal 5'-Phosphate): 20.4 mg
- Folate (1.2 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt): 2 mg DFE
- Vitamin B12 (as Methylcobalamin): 1.2 mg
- Betaine Anhydrous (Trimethylglycine): 1.8 g
Other Ingredients: Hypromellose (derived from cellulose) capsule, Silicon Dioxide, Calcium Citrate, Calcium Laurate.

Suggested Use / Directions
Take 3 capsules two times daily or as recommended by a health-care practitioner. Servings Per Container: 60.

Safety Information
If pregnant, consult your health-care practitioner before using this product. 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Product Quality & Testing
THORNE is committed to the highest standards of quality. Every supplement undergoes four rounds of rigorous testing to ensure purity, potency, and stability. This includes testing of raw materials, in-process testing, finished product testing, and stability testing. THORNE products are manufactured in the USA using US and imported ingredients, and are certified gluten-free and soy-free.



Media Resources
Official Product Videos
Learn about Thorne's Methyl-Guard
Video Description: This video provides an overview of Thorne's Methyl-Guard supplement, explaining its benefits and how it supports methylation.
Methyl-Guard | Thorne
Video Description: A concise video introducing Thorne's Methyl-Guard, highlighting its role in methylation support.
THORNE for Performance, Cognition, and Endurance
Video Description: This video explains how Thorne supplements, including Methyl-Guard, contribute to performance, cognition, and endurance.
Thorne Supplements - No Standard Higher
Video Description: A video emphasizing Thorne's commitment to high-quality supplement manufacturing and standards.
Are your supplements working?
Video Description: This video discusses the effectiveness of supplements and Thorne's approach to ensuring product efficacy.
What is Thorne's "No List"?
Video Description: A video explaining Thorne's 'No List' of undesirable ingredients, highlighting their commitment to clean formulations.
Specifications
| Attribute | Value |
|---|---|
| Item Form | Capsule |
| Diet Type | Gluten Free |
| Flavor | Unflavored |
| Product Benefits | Bone Health |
| Manufacturer | Thorne Research |
| Product Dimensions | 2.89 x 2.89 x 5.22 inches; 0.01 ounces |
| Date First Available | April 11, 2005 |
Warranty & Support
For specific warranty information or product support, please refer to the product packaging or contact THORNE customer service directly. Contact details can typically be found on the product label or the official THORNE website.
Legal Disclaimer
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
